Pyridine, quinoline, and isoquinoline N-oxides as kinase inhibitors
    6.
    发明授权
    Pyridine, quinoline, and isoquinoline N-oxides as kinase inhibitors 有权
    吡啶,喹啉和异喹啉N-氧化物作为激酶抑制剂

    公开(公告)号:US08071616B2

    公开(公告)日:2011-12-06

    申请号:US12692845

    申请日:2010-01-25

    摘要: This invention relates to urea compounds containing a pyridine, quinoline, or isoquinoline functionality which is oxidized at the nitrogen heteroatom and which are useful in the treatment of (i) raf mediated diseases, for example, cancer, (ii) p38 mediated diseases such as inflammation and osteoporosis, and (iii) VEGF mediated diseases such as angiogenesis disorders.

    摘要翻译: 本发明涉及含有吡啶,喹啉或异喹啉官能团的脲化合物,其在氮杂原子处被氧化并且可用于治疗(i)raf介导的疾病,例如癌症,(ii)p38介导的疾病,例如 炎症和骨质疏松症,和(iii)VEGF介导的疾病如血管生成障碍。

    Quinoline Derivatives and Their Use as Pesticides
    8.
    发明申请
    Quinoline Derivatives and Their Use as Pesticides 审中-公开
    喹啉衍生物及其作为农药的用途

    公开(公告)号:US20090029855A1

    公开(公告)日:2009-01-29

    申请号:US12282608

    申请日:2007-03-12

    CPC分类号: C07D215/12 C07D215/60

    摘要: This invention relates to quinoline derivatives of formula I wherein R1, R2, R3 are each independently halogen, hydroxy, cyano, amino, nitro, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C4-alkyl, C1-C6-alkoxy, C2-C6-alkenyloxy, C2-C6-alkynyloxy, C1-C4-alkoxy-C1-C4-alkoxy, C3-C7-cycloalkyl-C1-C4-alkoxy, C(OH)(CF3)2, C1-C6-haloalkyl, C1-C6-haloalkoxy, C1-C6-alkylthio, C1-C6-haloalkylthio, C1-C6-alkylsulfinyl, C1-C6-haloalkylsulfinyl, C1-C6-alkylsulfonyl, C1-C6-haloalkylsulfonyl, C(Ra)═O, C(Ra)═NORb, C(═O)ORx, or C(═O)NRxRy; Ra is hydrogen or C1-C4-alkyl; Rb is hydrogen, C1-C4-alkyl, C2-C4-alkenyl, C2-C4-alkynyl, C1-C4-haloalkyl, or C2-C4-haloalkenyl; Rx, Ry are each independently hydrogen, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy-C1-C4-alkyl, C1-C4-thioalkyl-C1-C4-alkyl, C1-C4-alkyl-S(═O)C1-C4-alkyl, C1-C4-alkyl-S(═O)2C1-C4-alkyl, C3-C6-cyloalkyl, C1-C4-alkyl-C3-C6-cycloalkyl, C3-C6-alkenyl, C3-C6-alkinyl; R4, R5, R6, R7 are each independently hydrogen, halogen, cyano, amino, nitro, hydroxy, C1-C6-alkyl, C1-C6-alkoxy, C1-C6-haloalkyl, C1-C6-haloalkoxy, C1-C6-alkylthio, C1-C6-haloalkylthio, C1-C6-alkylsulfinyl, C1-C6-haloalkylsulfinyl, C1-C6-alkylsulfonyl, C1-C6-haloalkylsulfonyl, or C(═O)ORc; Rc is hydrogen, C1-C6-alkyl, C2-C6-alkenyl, or C2-C6-alkinyl; m and n are each independently 1, 2, 3, 4, or 5; p is 0, 1, 2, 3, 4, or 5; and the N-oxides, enantiomers, diastereomers and salts thereof, processes and intermediates for the preparation of compounds I, use of compounds I for combating insects, acarids, or nematodes and a method for treating, controlling, preventing or protecting animals against infestation or infection by parasites using compounds I.

    摘要翻译: 本发明涉及式I的喹啉衍生物,其中R 1,R 2,R 3各自独立地为卤素,羟基,氰基,氨基,硝基,C 1 -C 6烷基,C 2 -C 6 - 烯基,C 2 -C 6炔基,C 3 -C 7 - 环烷基,C 3 -C 7 - 环烷基-C 1 -C 4 - 烷基,C 1 -C 6 - 烷氧基,C 2 -C 6 - 烯氧基,C 2 -C 6 - 炔氧基,C 1 -C 4烷氧基-C 1 -C 4烷氧基,C 3 -C 7 - 环烷基 - C 1 -C 6烷氧基,C(OH)(CF 3)2,C 1 -C 6卤代烷基,C 1 -C 6卤代烷氧基,C 1 -C 6烷硫基,C 1 -C 6卤代烷硫基,C 1 -C 6烷基亚磺酰基, C 1 -C 6烷基磺酰基,C 1 -C 6卤代烷基磺酰基,C(R a)-O,C(R a)-NOR b,C(-O)OR x或C(-O)NR x R y; R a是氢或C 1 -C 4 - 烷基; R b是氢,C 1 -C 4 - 烷基,C 2 -C 4 - 烯基,C 2 -C 4 - 炔基,C 1 -C 4卤代烷基或C 2 -C 4 - 卤代烯基; R x,R y各自独立地为氢,C 1 -C 4 - 烷基,C 1 -C 4 - 卤代烷基,C 1 -C 4 - 烷氧基-C 1 -C 4烷基,C 1 -C 4 - 硫代烷基-C 1 -C 4烷基,C 1 -C 4烷基 - S(-O)C 1 -C 4 - 烷基,C 1 -C 4烷基-S(-O)2 C 1 -C 4烷基,C 3 -C 6 - 环烷基,C 1 -C 4烷基-C 3 -C 6环烷基,C 3 -C 6 - 烯基,C 3 -C 6 - 炔基; R4,R5,R6,R7各自独立地为氢,卤素,氰基,氨基,硝基,羟基,C1-C6-烷基,C1-C6-烷氧基,C1-C6-卤代烷基,C1-C6-卤代烷氧基,C1-C6- C 1 -C 6烷基亚磺酰基,C 1 -C 6烷基磺酰基,C 1 -C 6卤代烷基磺酰基或C(-O)OR c; R c是氢,C 1 -C 6 - 烷基,C 2 -C 6 - 烯基或C 2 -C 6 - 炔基; m和n各自独立地为1,2,3,4或5; p是0,1,2,3,4或5; 及其N-氧化物,对映异构体,非对映异构体及其盐,制备化合物I的方法和中间体,化合物I用于防治昆虫,螨虫或线虫的用途,以及用于治疗,控制,预防或保护动物免受感染或 使用化合物I的寄生虫感染

    Quinoline Tachykinin Receptor Antagonists
    10.
    发明申请
    Quinoline Tachykinin Receptor Antagonists 审中-公开
    喹啉速激肽受体拮抗剂

    公开(公告)号:US20070293492A1

    公开(公告)日:2007-12-20

    申请号:US11791241

    申请日:2005-11-29

    摘要: The present invention is directed to certain quinoline compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.

    摘要翻译: 本发明涉及可用作神经激肽-1(NK-1)受体拮抗剂,速激肽抑制剂,特别是物质P的某些喹啉化合物。本发明还涉及包含这些化合物作为活性成分的药物制剂和 使用化合物及其制剂治疗某些疾病,包括呕吐,尿失禁,抑郁和焦虑。