公开(公告)号：US08293741B2

公开(公告)日：2012-10-23

申请号：US11119021

申请日：2005-04-29

申请人： James A. Burke ,  Patrick M. Hughes ,  Kai-Ming Zhang ,  Ton Lin ,  Glenn Huang ,  Brittany A. Jackson ,  Larry A. Wheeler ,  Rosy S. Donn

发明人： James A. Burke ,  Patrick M. Hughes ,  Kai-Ming Zhang ,  Ton Lin ,  Glenn Huang ,  Brittany A. Jackson ,  Larry A. Wheeler ,  Rosy S. Donn

IPC分类号： A61K31/495

CPC分类号： A61L31/148 ,  A61K9/0051 ,  A61K9/204 ,  A61K31/498 ,  A61K47/34 ,  A61L27/58 ,  A61L31/06 ,  A61L31/16 ,  A61L2300/436 ,  A61L2300/604 ,  C08L67/04 ,  Y02A50/401

摘要： Biocompatible intraocular implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants can be placed in an eye to treat one or more ocular conditions, such as an ocular vasculopathy or glaucoma, among others or to improve vision in a normal eye.

摘要翻译： 生物相容性眼内植入物包括α-2肾上腺素能受体激动剂和与α-2肾上腺素能受体激动剂相关的聚合物，以促进α-2肾上腺素能受体激动剂延长一段时间的眼睛释放。 α-2肾上腺素能受体激动剂可以与可生物降解的聚合物基质例如两种可生物降解的聚合物的基质相关联。 植入物可以放置在眼睛中以治疗一种或多种眼部病症，例如眼睛血管病变或青光眼等，或改善正常眼睛的视力。

公开(公告)号：US20080299178A1

公开(公告)日：2008-12-04

申请号：US12142071

申请日：2008-06-19

申请人： James Burke ,  Patrick M. Hughes ,  Orilla C. Werhner ,  Ton Lin ,  Maria Escobar ,  Glenn Huang ,  Kai-Ming Zhang ,  Larry A. Wheeler ,  Rosy S. Donn

发明人： James Burke ,  Patrick M. Hughes ,  Orilla C. Werhner ,  Ton Lin ,  Maria Escobar ,  Glenn Huang ,  Kai-Ming Zhang ,  Larry A. Wheeler ,  Rosy S. Donn

IPC分类号： A61F2/02 ,  A61P27/02

CPC分类号： A61K31/498 ,  A61K9/0051 ,  A61K47/34

摘要： Biocompatible intraocular microspheres and implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants may be placed in an eye to treat or to prevent the occurrence of one or more ocular conditions, to reduce one or more symptoms of an ocular condition, such as an ocular neurosensory disorder and the like, to enhance normal retinal function and/or to lower intraocular pressure.

公开(公告)号：US20080260832A1

公开(公告)日：2008-10-23

申请号：US12142083

申请日：2008-06-19

申请人： James Burke ,  Patrick M. Hughes ,  Orilla C. Werhner ,  Ton Lin ,  Maria Escobar ,  Glenn Huang ,  Kai-Ming Zhang ,  Larry A. Wheeler ,  Rosy S. Donn

发明人： James Burke ,  Patrick M. Hughes ,  Orilla C. Werhner ,  Ton Lin ,  Maria Escobar ,  Glenn Huang ,  Kai-Ming Zhang ,  Larry A. Wheeler ,  Rosy S. Donn

IPC分类号： A61K9/00 ,  A61K31/498 ,  A61P27/02

CPC分类号： A61K31/498 ,  A61K9/0051 ,  A61K47/34

摘要： Biocompatible intraocular microspheres and implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants may be placed in an eye to treat or to prevent the occurrence of one or more ocular conditions, to reduce one or more symptoms of an ocular condition, such as an ocular neurosensory disorder and the like, to enhance normal retinal function and/or to lower intraocular pressure.

摘要翻译： 生物相容性眼内微球和植入物包括α-2肾上腺素能受体激动剂和与α-2肾上腺素能受体激动剂相关联的聚合物，以促进α-2肾上腺素能受体激动剂延长一段时间的眼睛释放。 α-2肾上腺素能受体激动剂可以与可生物降解的聚合物基质例如两种可生物降解的聚合物的基质相关联。 植入物可以放置在眼睛中以治疗或防止一种或多种眼部病症的发生，以减少眼部疾病如眼部神经感觉障碍等的一种或多种症状，以增强正常的视网膜功能和/ 或降低眼内压。

公开(公告)号：US08609144B2

公开(公告)日：2013-12-17

申请号：US12142083

申请日：2008-06-19

申请人： James Burke ,  Patrick M. Hughes ,  Orilla C. Werhner ,  Ton C. Lin ,  Maria Escobar ,  Glenn Huang ,  Kai-Ming Zhang ,  Larry A. Wheeler ,  Rosy S. Donn

发明人： James Burke ,  Patrick M. Hughes ,  Orilla C. Werhner ,  Ton C. Lin ,  Maria Escobar ,  Glenn Huang ,  Kai-Ming Zhang ,  Larry A. Wheeler ,  Rosy S. Donn

IPC分类号： A61K9/00 ,  A61K31/498 ,  A61P27/02

CPC分类号： A61K31/498 ,  A61K9/0051 ,  A61K47/34

摘要： Biocompatible intraocular microspheres and implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants may be placed in an eye to treat or to prevent the occurrence of one or more ocular conditions, to reduce one or more symptoms of an ocular condition, such as an ocular neurosensory disorder and the like, to enhance normal retinal function and/or to lower intraocular pressure.

摘要翻译： 生物相容的眼内微球和植入物包括α-2肾上腺素能受体激动剂和与α-2肾上腺素能受体激动剂相关的聚合物，以促进α-2肾上腺素能受体激动剂延长一段时间的眼睛释放。 α-2肾上腺素能受体激动剂可以与可生物降解的聚合物基质例如两种可生物降解的聚合物的基质相关联。 植入物可以放置在眼睛中以治疗或防止一种或多种眼部病症的发生，以减少眼部疾病如眼部神经感觉障碍等的一种或多种症状，以增强正常的视网膜功能和/ 或降低眼内压。

公开(公告)号：US08293210B2

公开(公告)日：2012-10-23

申请号：US11927615

申请日：2007-10-29

申请人： Glenn T. Huang ,  James Burke ,  Patrick M. Hughes ,  Kai-Ming Zhang ,  Ton Lin ,  Larry A. Wheeler ,  Rosy Sheng Donn

发明人： Glenn T. Huang ,  James Burke ,  Patrick M. Hughes ,  Kai-Ming Zhang ,  Ton Lin ,  Larry A. Wheeler ,  Rosy Sheng Donn

IPC分类号： A61K31/498 ,  A61P27/16

CPC分类号： A61K31/498 ,  A61K9/0051 ,  A61K47/34

摘要： Biocompatible intraocular implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants may be placed in an eye to prevent the occurrence of one or more ocular conditions, or to reduce one or more symptoms of an ocular condition, such as an ocular neurosensory disorder and the like.

摘要翻译： 生物相容性眼内植入物包括α-2肾上腺素能受体激动剂和与α-2肾上腺素能受体激动剂相关的聚合物，以促进α-2肾上腺素能受体激动剂延长一段时间的眼睛释放。 α-2肾上腺素能受体激动剂可以与可生物降解的聚合物基质例如两种可生物降解的聚合物的基质相关联。 植入物可以放置在眼睛中以防止发生一种或多种眼部病症，或者减少眼部疾病如眼睛神经感觉障碍等的一种或多种症状。

公开(公告)号：US20110251201A1

公开(公告)日：2011-10-13

申请号：US13154079

申请日：2011-06-06

申请人： Glenn T. Huang ,  James Burke ,  Patrick M. Hughes ,  Kai-Ming Zhang ,  Ton Lin ,  Larry A. Wheeler ,  Rosy Sheng Donn

发明人： Glenn T. Huang ,  James Burke ,  Patrick M. Hughes ,  Kai-Ming Zhang ,  Ton Lin ,  Larry A. Wheeler ,  Rosy Sheng Donn

IPC分类号： A61K31/498 ,  A61P27/02

CPC分类号： A61K31/498 ,  A61K9/0051 ,  A61K47/34

摘要： Biocompatible intraocular implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants may be placed in an eye to prevent the occurrence of one or more ocular conditions, or to reduce one or more symptoms of an ocular condition, such as an ocular neurosensory disorder and the like.

摘要翻译： 生物相容性眼内植入物包括α-2肾上腺素能受体激动剂和与α-2肾上腺素能受体激动剂相关的聚合物，以促进α-2肾上腺素能受体激动剂延长一段时间的眼睛释放。 α-2肾上腺素能受体激动剂可以与可生物降解的聚合物基质例如两种可生物降解的聚合物的基质相关联。 植入物可以放置在眼睛中以防止发生一种或多种眼部病症，或者减少眼部疾病如眼睛神经感觉障碍等的一种或多种症状。

公开(公告)号：US08425929B2

公开(公告)日：2013-04-23

申请号：US10837143

申请日：2004-04-30

申请人： Glenn T. Huang ,  James Burke ,  Patrick M. Hughes ,  Kai-Ming Zhang ,  Ton Lin ,  Larry A. Wheeler ,  Rosy Sheng Donn

发明人： Glenn T. Huang ,  James Burke ,  Patrick M. Hughes ,  Kai-Ming Zhang ,  Ton Lin ,  Larry A. Wheeler ,  Rosy Sheng Donn

IPC分类号： A61F2/02

CPC分类号： A61K31/498 ,  A61K9/0051 ,  A61K47/34

摘要： Biocompatible intraocular implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants may be placed in an eye to prevent the occurrence of one or more ocular conditions, or to reduce one or more symptoms of an ocular condition, such as an ocular neurosensory disorder and the like.

公开(公告)号：US20080131372A1

公开(公告)日：2008-06-05

申请号：US11927615

申请日：2007-10-29

申请人： Glenn T. Huang ,  James Burke ,  Patrick M. Hughes ,  Kai-Ming Zhang ,  Ton Lin ,  Larry A. Wheeler ,  Rosy Sheng Donn

发明人： Glenn T. Huang ,  James Burke ,  Patrick M. Hughes ,  Kai-Ming Zhang ,  Ton Lin ,  Larry A. Wheeler ,  Rosy Sheng Donn

IPC分类号： A61K31/498 ,  A61P27/16

CPC分类号： A61K31/498 ,  A61K9/0051 ,  A61K47/34

摘要： Biocompatible intraocular implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants may be placed in an eye to prevent the occurrence of one or more ocular conditions, or to reduce one or more symptoms of an ocular condition, such as an ocular neurosensory disorder and the like.

摘要翻译： 生物相容性眼内植入物包括α-2肾上腺素能受体激动剂和与α-2肾上腺素能受体激动剂相关的聚合物，以促进α-2肾上腺素能受体激动剂延长一段时间的眼睛释放。 α-2肾上腺素能受体激动剂可以与可生物降解的聚合物基质例如两种可生物降解的聚合物的基质相关联。 植入物可以放置在眼睛中以防止发生一种或多种眼部病症，或者减少眼部疾病如眼睛神经感觉障碍等的一种或多种症状。

公开(公告)号：US20080131485A1

公开(公告)日：2008-06-05

申请号：US11927613

申请日：2007-10-29

申请人： Glenn T. Huang ,  James Burke ,  Patrick M. Hughes ,  Kai-Ming Zhang ,  Ton Lin ,  Larry A. Wheeler ,  Rosy Sheng Donn

发明人： Glenn T. Huang ,  James Burke ,  Patrick M. Hughes ,  Kai-Ming Zhang ,  Ton Lin ,  Larry A. Wheeler ,  Rosy Sheng Donn

IPC分类号： A61K9/00 ,  A61K31/498

CPC分类号： A61K31/498 ,  A61K9/0051 ,  A61K47/34

摘要： Biocompatible intraocular implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants may be placed in an eye to prevent the occurrence of one or more ocular conditions, or to reduce one or more symptoms of an ocular condition, such as an ocular neurosensory disorder and the like.

公开(公告)号：US20050244476A1

公开(公告)日：2005-11-03

申请号：US11119021

申请日：2005-04-29

申请人： James Burke ,  Patrick Hughes ,  Kai-Ming Zhang ,  Ton Lin ,  Glenn Huang ,  Brittany Jackson ,  Larry Wheeler ,  Rosy Donn

发明人： James Burke ,  Patrick Hughes ,  Kai-Ming Zhang ,  Ton Lin ,  Glenn Huang ,  Brittany Jackson ,  Larry Wheeler ,  Rosy Donn

IPC分类号： A61K9/00 ,  A61K31/498 ,  A61F2/00

CPC分类号： A61L31/148 ,  A61K9/0051 ,  A61K9/204 ,  A61K31/498 ,  A61K47/34 ,  A61L27/58 ,  A61L31/06 ,  A61L31/16 ,  A61L2300/436 ,  A61L2300/604 ,  C08L67/04 ,  Y02A50/401

摘要： Biocompatible intraocular implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants can be placed in an eye to treat one or more ocular conditions, such as an ocular vasculopathy or glaucoma, among others or to improve vision in a normal eye.

摘要翻译： 生物相容性眼内植入物包括α-2肾上腺素能受体激动剂和与α-2肾上腺素能受体激动剂相关的聚合物，以促进α-2肾上腺素能受体激动剂延长一段时间的眼睛释放。 α-2肾上腺素能受体激动剂可以与可生物降解的聚合物基质例如两种可生物降解的聚合物的基质相关联。 植入物可以放置在眼睛中以治疗一种或多种眼部病症，例如眼睛血管病变或青光眼等，或改善正常眼睛的视力。