公开(公告)号：US5663398A

公开(公告)日：1997-09-02

申请号：US711878

申请日：1996-09-12

申请人： James Anthony Schwindeman ,  Eric John Granger ,  Douglas Earl Sutton

发明人： James Anthony Schwindeman ,  Eric John Granger ,  Douglas Earl Sutton

IPC分类号： C07F7/08 ,  C07F7/10 ,  C07F7/18

CPC分类号： C07F7/10 ,  C07F7/0898 ,  C07F7/1864

摘要： A process for preparing functionalized alkyllithium compounds includes reacting in an inert solvent a protected functionalized alkyl halide with an alkali metal in the presence of a catalytic compound of the formula(RR.sup.1 R.sup.2 M.sup.a).sub.y A(R.sup.3).sub.xwherein R, R.sup.1 and R.sup.2 are each independently selected from the group consisting of hydrogen, halogen, alkyl or alkenyl groups containing one to thirteen carbon atoms; R.sup.3 is independently selected from aryl groups containing 6 to 18 carbon atoms, four to six-membered heterocyclic carbon containing groups containing one to two heteroatoms selected from oxygen, nitrogen and sulfur; hydroxyalkyl, alkoxyalkyl, monoalkylaminoalkyl, dialkylaminoalkyl and dialkylphosphinoalkyl groups containing two to thirteen carbon atoms; M.sup.a is an element selected from Group IVA of the Periodic Table of Elements; A is selected from oxygen, sulfur, nitrogen, and phosphorus; x+y equal the valence of A; and x and y may independently have a value from zero to three.

摘要翻译： 制备官能化的烷基锂化合物的方法包括在惰性溶剂中，在式（RR 1 R 2 Ma）y A（R 3）x的催化化合物的存在下，将保护的官能化烷基卤与碱金属反应，其中R，R 1和R 2各自独立地选择 由含有1至13个碳原子的氢，卤素，烷基或链烯基组成的组; R3独立地选自含有6至18个碳原子的芳基，含有1至2个选自氧，氮和硫的杂原子的含有4至6元杂环碳的基团; 羟基烷基，烷氧基烷基，一烷基氨基烷基，二烷基氨基烷基和含有二至十三个碳原子的二烷基膦基烷基; Ma是选自元素周期表IVA组的元素; A选自氧，硫，氮和磷; x + y等于A的化合价; 并且x和y可以独立地具有从零到三的值。