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120 条记录 (耗时 0.035 秒)

    Release rate adjustment of osmotic or diffusional delivery devices
    1.
    发明授权
    Release rate adjustment of osmotic or diffusional delivery devices 失效
    渗透或扩散输送装置的释放速率调节

    公开(公告)号：US4865845A

    公开(公告)日：1989-09-12

    申请号：US90720

    申请日：1987-08-28

    申请人： James B. Eckenhoff ,  John Urquhart

    发明人： James B. Eckenhoff ,  John Urquhart

    IPC分类号： A61K9/00

    CPC分类号： A61K9/0004

    摘要： A sleeve shaped structure covers a portion of the transport area of a diffusional or osmotic delivery device. The structure is durable and inert to the use environment. Markings on the structure indicate where breaking or cutting will produce a predictable alteration in delivery rate. Among other attachment means, a water soluble adhesive maintains the structure on the delivery device.

    摘要翻译： 套筒形结构覆盖扩散或渗透输送装置的输送区域的一部分。 该结构对使用环境是耐用的和惰性的。 结构上的标记表明断裂或切割会产生预期的输送率变化。 在其他附着装置中，水溶性粘合剂将结构保持在输送装置上。

    Polyurethane-containing delivery systems
    4.
    发明授权
    Polyurethane-containing delivery systems 失效
    含聚氨酯的输送系统

    公开(公告)号：US06180129B2

    公开(公告)日：2001-01-30

    申请号：US08956424

    申请日：1997-10-23

    申请人： Judy A. Magruder ,  James B. Eckenhoff ,  Richard Cortese ,  Jeremy C. Wright ,  John R. Peery

    发明人： Judy A. Magruder ,  James B. Eckenhoff ,  Richard Cortese ,  Jeremy C. Wright ,  John R. Peery

    IPC分类号： A61K914

    CPC分类号： A61K9/0004 ,  A61M31/002

    摘要： A delivery system is disclosed for delivering a beneficial agent to an animal. The delivery system comprises a wall that surrounds a lumen, said wall comprising a composition that limits the passage of fluid into the system and a composition that permits the passage of fluid into the system. The lumen comprises a beneficial agent and an expandable member. The delivery system comprises an exit means for delivering the beneficial agent.

    摘要翻译： 公开了用于将有益剂递送到动物的递送系统。 递送系统包括围绕内腔的壁，所述壁包括限制流体进入系统的组合物和允许流体进入系统的组合物。 管腔包括有益剂和可膨胀构件。 递送系统包括用于递送有益剂的出口装置。

    Delivery system comprising means for controlling internal pressure
    6.
    发明授权
    Delivery system comprising means for controlling internal pressure 失效
    输送系统包括用于控制内部压力的装置

    公开(公告)号：US5474785A

    公开(公告)日：1995-12-12

    申请号：US092301

    申请日：1993-07-15

    申请人： Jeremy C. Wright ,  James B. Eckenhoff ,  Frederick H. Maruyama ,  John R. Peery

    发明人： Jeremy C. Wright ,  James B. Eckenhoff ,  Frederick H. Maruyama ,  John R. Peery

    IPC分类号： A61K9/00 ,  A61K9/24

    CPC分类号： A61K9/0068 ,  A61K9/0004

    摘要： The present invention is directed to an improvement in a delivery system, the system comprising a wall that surrounds an internal lumen or compartment which contains a thermo-responsive beneficial agent formulation, an expandable driving member and an optional density member, and having an exit opening, and wherein the improvement comprises a) a viscosity-inducing amount of an inert viscosity-inducing agent in the thermo-responsive beneficial agent composition for increasing the viscosity of the beneficial agent composition, and/or b) a pressure-inducing exit member in the exit opening in the wall for increasing the pressure inside the lumen.

    摘要翻译： 本发明涉及递送系统的改进，该系统包括围绕包含热响应有益剂制剂的内腔或隔室的壁，可膨胀驱动构件和任选的密封构件，并且具有出口 并且其中改进包括a）在用于增加有益剂组合物的粘度的热响应有益剂组合物中的惰性粘度诱导剂的粘度诱导量，和/或b）压力诱导出口部件 壁中的出口开口用于增加内腔内的压力。

    Method for increasing feed efficiency in animals
    7.
    发明授权
    Method for increasing feed efficiency in animals 失效
    提高动物饲料效率的方法

    公开(公告)号：US5234694A

    公开(公告)日：1993-08-10

    申请号：US939263

    申请日：1992-09-02

    申请人： Judy A. Magruder ,  John R. Peery ,  James B. Eckenhoff

    发明人： Judy A. Magruder ,  John R. Peery ,  James B. Eckenhoff

    IPC分类号： A61K9/00 ,  A61K9/22

    CPC分类号： A61K9/0004

    摘要： This invention relates to an active agent delivery device. More particularly, the invention relates to a delivery device that includes a sleeve to protect the delivery device from transient mechanical forces. The delivery device of the invention is robust and resistant to transient mechanical forces. The invention provides a fluid-imbibing delivery device comprising a housing enclosing an internal compartment, said housing having a first wall section that substantially restricts the passage of fluid into the delivery device, i.e. is substantially fluid-impermeable, and that contains a beneficial agent; a second wall section that permits the passage of fluid into the delivery device, i.e. is fluid-permeable, and that contains at least one expandable driving member; and exit means; with a protective sleeve means extending from the first wall section of the housing to cover and protect the second wall section of the housing and the junction of the first and second sections. The protective sleeve is preferably configured to provide substantially no resistance to flow of fluid or fluid vapor through the fluid-permeable second wall section.

    摘要翻译： 本发明涉及活性剂递送装置。 更具体地，本发明涉及一种输送装置，其包括用于保护输送装置免受瞬时机械力的套筒。 本发明的输送装置是坚固的并且耐瞬态机械力。 本发明提供了一种流体吸收递送装置，其包括封闭内部隔室的壳体，所述壳体具有基本上限制流体进入输送装置的第一壁部分，即基本上不流体渗透，并且包含有益剂; 允许流体进入输送装置的第二壁部分，即流体可渗透的，并且其包含至少一个可膨胀的驱动构件; 出口手段; 具有从壳体的第一壁部分延伸以覆盖并保护壳体的第二壁部分和第一和第二部分的连接处的保护套筒装置。 保护套管优选地构造成基本上不提供通过流体可渗透的第二壁部分的流体或流体蒸气的流动阻力。

    Multi-layer delivery system
    10.
    发明授权
    Multi-layer delivery system 失效
    多层交付系统

    公开(公告)号：US4957494A

    公开(公告)日：1990-09-18

    申请号：US283631

    申请日：1988-12-13

    申请人： Patrick S. L. Wong ,  Felix Theeuwes ,  James B. Eckenhoff

    发明人： Patrick S. L. Wong ,  Felix Theeuwes ,  James B. Eckenhoff

    IPC分类号： A61K9/00 ,  A61M31/00

    CPC分类号： A61M31/002 ,  A61K9/0004

    摘要： A dispenser for use in a fluid environment which is capable of delivery of plurality of discrete drug containing layers in any desired delivery pattern or profile. The dispenser comprises a rigid housing containing a plurality of drug layers which may be separated by drug-free layers. An outlet is provided at one end of the housing and a fluid actuated driving means is provided between the other end of the housing and the drug layers. The portion of the housing in proximity to the driving means has a controlled permeability to water whereby, upon immersion in a fluid environment the drug layers are driven towards the outlet. Various delivery patterns are possible by appropriate selection of the comparison and dimensions of the drug and drug-free layers.

    摘要翻译： 一种在流体环境中使用的分配器，其能够以任何期望的输送模式或轮廓递送多个离散的含药层。 分配器包括容纳多个药物层的刚性壳体，其可由无药物层分离。 出口设在壳体的一端，并且流体驱动的驱动装置设置在壳体的另一端和药物层之间。 壳体靠近驱动装置的部分对水具有受控的渗透性，因此当浸入流体环境中时，药物层朝着出口被驱动。 可以通过适当选择药物和无药物层的比较和尺寸来实现各种递送模式。