利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

45 条记录 (耗时 0.019 秒)

    Release rate adjustment of osmotic or diffusional delivery devices
    1.
    发明授权
    Release rate adjustment of osmotic or diffusional delivery devices 失效
    渗透或扩散输送装置的释放速率调节

    公开(公告)号：US4865845A

    公开(公告)日：1989-09-12

    申请号：US90720

    申请日：1987-08-28

    申请人： James B. Eckenhoff ,  John Urquhart

    发明人： James B. Eckenhoff ,  John Urquhart

    IPC分类号： A61K9/00

    CPC分类号： A61K9/0004

    摘要： A sleeve shaped structure covers a portion of the transport area of a diffusional or osmotic delivery device. The structure is durable and inert to the use environment. Markings on the structure indicate where breaking or cutting will produce a predictable alteration in delivery rate. Among other attachment means, a water soluble adhesive maintains the structure on the delivery device.

    摘要翻译： 套筒形结构覆盖扩散或渗透输送装置的输送区域的一部分。 该结构对使用环境是耐用的和惰性的。 结构上的标记表明断裂或切割会产生预期的输送率变化。 在其他附着装置中，水溶性粘合剂将结构保持在输送装置上。

    Intestine drug delivery
    2.
    发明授权
    Intestine drug delivery 失效
    肠道给药

    公开(公告)号：US4863744A

    公开(公告)日：1989-09-05

    申请号：US26236

    申请日：1987-03-16

    申请人： John Urquhart ,  Felix Theeuwes

    发明人： John Urquhart ,  Felix Theeuwes

    IPC分类号： A61K9/20

    CPC分类号： A61K9/2081

    摘要： A delivery system is disclosed for delivering an agent to a selected environment of use having a pH of greater than 3.5.

    摘要翻译： 公开了用于将试剂递送到pH大于3.5的所选择的使用环境的递送系统。

    Parenteral controlled delivery
    3.
    发明授权
    Parenteral controlled delivery 失效
    肠外控制递送

    公开(公告)号：US4525162A

    公开(公告)日：1985-06-25

    申请号：US587781

    申请日：1984-03-09

    申请人： John Urquhart ,  Felix Theeuwes

    发明人： John Urquhart ,  Felix Theeuwes

    IPC分类号： A61M5/14 ,  A61M5/16

    CPC分类号： A61M5/1407

    摘要： A parenteral delivery set is disclosed for administering a beneficial agent to a recipient. The set comprises (a) a primary container of a medical fluid; (b) a primary tubing in fluid communication with the primary container; (c) a secondary container of a medical fluid; (d) a secondary tubing in fluid communication with the secondary container; (e) a formulation chamber connected to the secondary tubing and housing an agent dispensing device or the beneficial agent; and (f) a common tubing in communication with the primary tubing and the secondary tubing for communicating the set to the recipient.

    摘要翻译： 公开了一种用于向接受者施用有益剂的胃肠外递送组。 该组包括（a）医用流体的主要容器; （b）与主容器流体连通的主管; （c）药液的二次容器; （d）与次级容器流体连通的第二管道; （e）与第二管道连接并容纳药剂分配装置或有益药剂的制剂室; 和（f）与主管道和第二管道连通的通用管道，用于将设备传送到接收器。

    Method for administering scopolamine transdermally
    4.
    发明授权
    Method for administering scopolamine transdermally 失效
    透皮给药东莨菪碱的方法

    公开(公告)号：US4436741A

    公开(公告)日：1984-03-13

    申请号：US474754

    申请日：1983-03-14

    申请人： John Urquhart ,  Santosh K. Chandrasekaran ,  Jane E. Shaw

    发明人： John Urquhart ,  Santosh K. Chandrasekaran ,  Jane E. Shaw

    IPC分类号： A61F13/00 ,  A61F13/15 ,  A61K9/70 ,  A61K31/46 ,  A61M37/00 ,  A61K31/445

    CPC分类号： A61K9/7053 ,  A61K31/46 ,  A61K9/7084 ,  A61M37/00 ,  A61F2013/00646 ,  Y10S514/872 ,  Y10S514/946

    摘要： Method and therapeutic system in the form of a bandage that administer scopolamine base transdermally in an initial pulse of 10 to 200 .mu.g/cm.sup.2 of skin that quickly brings the concentration of scopolamine in the plasma to a level at which emesis and nausea are inhibited without intolerable side effects, followed by a substantially constant dosage in the range of 0.3 to 15 .mu.g/hr that holds said level. The bandage is a four-layer laminate of, from the top: a protective backing; a gelled, mineral oil-polyisobutene-scopolamine reservoir lamina that is the source of the constant dosage; a microporous membrane that controls the constant dosage rate; and a gelled, mineral oil-polyisobutene-scopolamine adhesive layer that is the source of the pulse dose and the means by which the bandage is attached to the skin.

    摘要翻译： 绷带形式的方法和治疗系统，其在10至200μg/ cm 2皮肤的初始脉冲中经皮肤施用东莨菪碱碱基，其迅速将血浆中东莨菪碱的浓度迅速地抑制到呕吐和恶心被抑制的水平，没有 不可容忍的副作用，接着是持续所述水平的0.3至15μg/ hr范围内的基本上恒定的剂量。 绷带是从顶部的四层层合物：保护性背衬; 固定剂量的来源的凝胶状矿物油 - 聚异丁烯 - 东莨菪碱储层; 控制恒定剂量率的微孔膜; 以及作为脉冲剂量的来源的胶凝的矿物油 - 聚异丁烯 - 东莨菪碱粘合剂层以及绷带附着于皮肤的手段。

    Systems and methods for medication monitoring
    7.
    发明授权
    Systems and methods for medication monitoring 有权
    用于药物监测的系统和方法

    公开(公告)号：US06822554B2

    公开(公告)日：2004-11-23

    申请号：US10342655

    申请日：2003-01-13

    申请人： Bernard Vrijens ,  John Urquhart ,  Erik De Klerk ,  Jean-Michel Metry

    发明人： Bernard Vrijens ,  John Urquhart ,  Erik De Klerk ,  Jean-Michel Metry

    IPC分类号： G08B100

    CPC分类号： G06Q50/22 ,  G06F19/00 ,  G06F19/3456 ,  G16H10/60 ,  G16H40/63 ,  G16H50/30 ,  Y10S706/924

    摘要： The present invention relates to a method and system of medication monitoring which includes analyzing data on the clinical consequences of variable patient compliance with prescribed drug regimens, communicating to caregivers and/or patients the compliance-dependent probabilities of two clinically important transitions in health status: substantive improvement in the patient's health status and substantive deterioration in the patient's health status, defining acceptable levels of the respective probabilities of deterioration and of improvement, and intervening when appropriate to improve the patient's compliance, in order to achieve mutually-agreed upon maintenance, improvement, or avoidance of deterioration in health status.

    摘要翻译： 本发明涉及药物监测的方法和系统，该方法和系统包括分析关于可变患者遵守规定的药物方案的临床后果的数据，向照顾者和/或患者传达健康状况中两个临床上重要的转变的依从性依赖性概率： 患者健康状况的实质性改善以及患者健康状况的实质性恶化，确定了相应的恶化和改善可能性的可接受水平，并在适当时进行干预，以改善患者的依从性，以实现相互同意的维护，改善 ，或避免健康状况恶化。

    Intravenous system for delivering a beneficial agent with delivery rate control via permeable surface area variance
    8.
    发明授权
    Intravenous system for delivering a beneficial agent with delivery rate control via permeable surface area variance 失效
    用于通过渗透性表面积差异递送有效药物的输送速率控制的静脉内系统

    公开(公告)号：US4969872A

    公开(公告)日：1990-11-13

    申请号：US320732

    申请日：1989-03-08

    申请人： John Urquhart ,  Felix Theeuwes

    发明人： John Urquhart ,  Felix Theeuwes

    IPC分类号： A61M39/00 ,  A61M5/14

    CPC分类号： A61M5/1409

    摘要： A drug formulation chamber for an intravenous administration set is provided. The intravenous administration set includes a container of an IV fluid, a drip chamber, a drug formulation chamber, and an adapter-needle assembly. The drug formulation chamber houses a diffusional or an osmotically driven drug delivery device. The osmotically driven delivery device has a semipermeable, microporous or diffusional wall which surrounds a compartment containing the drug. Drug is delivered through an orifice in the semipermeable/microporous wall or through the diffusional wall itself, into the IV fluid. The device delivers drug into the IV fluid at a rate that is independent of the flow rate of IV fluid through the formulation chamber. The rate of drug delivery is controlled by variably adjusting the surface area of the semipermeable/microporous/diffusional wall that is exposed to the IV fluid flowing through the drug formulation chamber.

    摘要翻译： 提供了用于静脉内给药组的药物制剂室。 静脉内给药组包括IV液体的容器，滴液室，药物制剂室和适配器 - 针组件。 药物制剂室容纳扩散或渗透驱动的药物递送装置。 渗透驱动的输送装置具有围绕包含药物的隔室的半透性，微孔或扩散壁。 药物通过半透膜/微孔壁中的孔口或通过扩散壁本身输送到IV液体中。 该装置以与通过制剂室的IV流体的流速无关的速率将药物递送到IV流体中。 通过可变地调节暴露于流过药物制剂室的IV液体的半透性/微孔/扩散壁的表面积来控制药物递送的速率。

    System for dispersing drug in biological environment
    10.
    发明授权
    System for dispersing drug in biological environment 失效
    生物环境中药物分散系统

    公开(公告)号：US4681583A

    公开(公告)日：1987-07-21

    申请号：US832192

    申请日：1986-02-24

    申请人： John Urquhart ,  Felix Theeuwes

    发明人： John Urquhart ,  Felix Theeuwes

    IPC分类号： A61J3/07 ,  A61K9/00 ,  A61J3/00

    CPC分类号： A61J3/07 ,  A61J3/071 ,  A61K9/0004

    摘要： A delivery system is disclosed comprising a wall surrounding a lumen containing a plurality of dosage delivery devices. The wall is formed of an environment sensitive material that releases the dosage forms into the environment. The dosage forms comprise a semipermeable wall surrounding a compartment containing drug. A passageway through the semipermeable wall releases drug from the dosage form to the environment.

    摘要翻译： 公开了包括围绕包含多个剂量递送装置的内腔的壁的输送系统。 该壁由将剂型释放到环境中的环境敏感材料形成。 剂型包括围绕含有药物的隔室的半透壁。 通过半透壁的通道将药物从剂型释放到环境中。