公开(公告)号：US10463983B2

公开(公告)日：2019-11-05

申请号：US15476799

申请日：2017-03-31

申请人： James B. Mitchell ,  Avi R. Geiger

发明人： James B. Mitchell ,  Avi R. Geiger

IPC分类号： B01D3/10 ,  B01D1/00 ,  B01D1/02 ,  B01D5/00 ,  B01D3/00

摘要： A distillation/extraction insert may attach to a vessel containing liquid to be distilled, and may use heated water circulating through a heating coil, as well as draw a partial vacuum to induce boiling. A condensation coil may collect the vapor and condense the vapor into distillate. A controller may monitor various temperatures and vacuum level to precisely control the heated water being used to boil components in the liquid. The heated water may be created by a beer making machine, which may have a temperature controlled recirculating water system. The insert may be a self-contained unit that attaches to a vessel, where the vessel may also be used for fermenting brewer's mash for distillation. In some cases, an extraction chamber may be used for collecting essential oils from various materials.

公开(公告)号：US09012647B2

公开(公告)日：2015-04-21

申请号：US13440092

申请日：2012-04-05

申请人： David A. Wink ,  Wilmarie Flores-Santana ,  S. Bruce King ,  Murali Krishna Cherukuri ,  James B. Mitchell

发明人： David A. Wink ,  Wilmarie Flores-Santana ,  S. Bruce King ,  Murali Krishna Cherukuri ,  James B. Mitchell

IPC分类号： A61K31/445 ,  C07D211/00 ,  C07D401/12 ,  C07D211/94 ,  A61K47/48

CPC分类号： C07D401/12 ,  A61K47/48061 ,  A61K47/545 ,  C07D211/94

摘要： Disclosed are nitroxide modified NSAID compounds of the formula (I) or a pharmaceutically acceptable salt or enantiomer thereof: in which R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and n are defined herein and pharmaceutical compositions thereof. Further disclosed is a method of treating or preventing various disorders, such as inflammation, cancer, diabetes, a cardiovascular disorder, weight gain, polyps, and/or chronic pain, in a patient comprising administering an effective amount of a compound or pharmaceutically acceptable salt or enantiomer of formula (I). A method of imaging the compound or pharmaceutically acceptable salt or enantiomer of formula (I) in the body of the animal is also provided.

摘要翻译： 公开了式（I）的硝基氧改性的NSAID化合物或其药学上可接受的盐或对映异构体：其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9，R 10，R 11和n如本文所定义 及其药物组合物。 进一步公开的是在患者中治疗或预防各种疾病，例如炎症，癌症，糖尿病，心血管疾病，体重增加，息肉和/或慢性疼痛的方法，包括给予有效量的化合物或药学上可接受的盐 或式（I）的对映异构体。 还提供了在动物体内成像式（I）的化合物或药学上可接受的盐或对映异构体的方法。

公开(公告)号：US08712499B2

公开(公告)日：2014-04-29

申请号：US13131165

申请日：2009-11-25

申请人： Sankaran Subramanian ,  Nallathamby Devasahayam ,  Shingo Matsumoto ,  James B. Mitchell ,  Murali Krishna Cherukuri ,  John A. Cook

发明人： Sankaran Subramanian ,  Nallathamby Devasahayam ,  Shingo Matsumoto ,  James B. Mitchell ,  Murali Krishna Cherukuri ,  John A. Cook

IPC分类号： A61B5/055

CPC分类号： G01R33/60 ,  G01N24/08 ,  G01N24/10 ,  G01R33/4833 ,  G01R33/485 ,  G01R33/50 ,  G01R33/56536 ,  G01R33/56563

摘要： An echo-based single point imaging (ESPI) system (10) providing high-resolution oxygen images of a sample is disclosed. The ESPI system (10) employs spin echo detection of the resonance from a spin probe and concurrent Single Point Imaging (SPI) for spatial encoding of the oxygen concentration within the sample. Images are derived by comparing spin echo intensities of two images reconstructed at two time points selected at identical time intervals on either side of a refocusing pulse, eliminating artifacts associated with sample magnetic susceptibility and field inhomogeneity effects.

摘要翻译： 公开了一种提供样品的高分辨率氧气图像的基于回波的单点成像（ESPI）系统（10）。 ESPI系统（10）采用自旋探测器的共振自旋回波检测和同时单点成像（SPI）进行空间编码样品中氧浓度的自旋回波检测。 通过比较在重聚焦脉冲的任一侧以相同的时间间隔选择的两个时间点重建的两个图像的自旋回波强度，消除与样品磁化率和场不均匀性影响相关联的伪像而导出图像。

公开(公告)号：US5789447A

公开(公告)日：1998-08-04

申请号：US527314

申请日：1995-09-12

申请人： David A. Wink, Jr. ,  James B. Mitchell ,  Angelo Russo ,  Murali C. Krishna ,  Ingeborg Hanbauer ,  Matthew B. Grisham ,  Daniel Neil Granger

发明人： David A. Wink, Jr. ,  James B. Mitchell ,  Angelo Russo ,  Murali C. Krishna ,  Ingeborg Hanbauer ,  Matthew B. Grisham ,  Daniel Neil Granger

IPC分类号： C07D295/22 ,  A61K31/10 ,  A61K31/13 ,  A61K31/135 ,  A61K31/14 ,  A61K31/15 ,  A61K31/16 ,  A61K31/195 ,  A61K31/198 ,  A61K31/215 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/445 ,  A61K31/4468 ,  A61K31/495 ,  A61K31/496 ,  A61K38/00 ,  A61K45/00 ,  A61P1/00 ,  A61P1/04 ,  A61P3/08 ,  A61P7/00 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P25/28 ,  A61P29/00 ,  A61P35/00 ,  A61P37/06 ,  A61P43/00 ,  C07D211/98 ,  C07D213/42 ,  C07D271/06 ,  A61K31/40

CPC分类号： A61K31/198 ,  A61K31/13 ,  A61K31/14 ,  A61K31/15

摘要： The present invention provides a method for treating oxygen free radical induced tissue damage associated with ischemia reperfusion injury, wherein nitric oxide is delivered to target cells/tissues through the administration of a nitric oxide-containing compound that spontaneously releases nitric oxide under physiological conditions without requiring the presence of oxygen.

摘要翻译： 本发明提供了一种治疗与缺血再灌注损伤相关的氧自由基诱导的组织损伤的方法，其中通过施用在生理条件下自发释放一氧化氮的一氧化氮的化合物将一氧化氮递送至靶细胞/组织，而不需要 氧气的存在。

公开(公告)号：US20180280826A1

公开(公告)日：2018-10-04

申请号：US15476799

申请日：2017-03-31

申请人： James B. Mitchell

发明人： James B. Mitchell

IPC分类号： B01D1/00 ,  B01D1/02 ,  B01D5/00 ,  B01D3/10 ,  B01D3/00

CPC分类号： B01D1/0082 ,  B01D1/02 ,  B01D3/001 ,  B01D3/10 ,  B01D5/0006 ,  B01D5/006

摘要： A distillation/extraction insert may attach to a vessel containing liquid to be distilled, and may use heated water circulating through a heating coil, as well as draw a partial vacuum to induce boiling. A condensation coil may collect the vapor and condense the vapor into distillate. A controller may monitor various temperatures and vacuum level to precisely control the heated water being used to boil components in the liquid. The heated water may be created by a beer making machine, which may have a temperature controlled recirculating water system. The insert may be a self-contained unit that attaches to a vessel, where the vessel may also be used for fermenting brewer's mash for distillation. In some cases, an extraction chamber may be used for collecting essential oils from various materials.

公开(公告)号：US08736380B2

公开(公告)日：2014-05-27

申请号：US13600748

申请日：2012-08-31

申请人： James B. Mitchell ,  Bliss G. Carkhuff ,  Morris L. London ,  Robert E. Ball, Sr. ,  Nathaniel J. Hundley

发明人： James B. Mitchell ,  Bliss G. Carkhuff ,  Morris L. London ,  Robert E. Ball, Sr. ,  Nathaniel J. Hundley

IPC分类号： H03F3/191

CPC分类号： H03G3/00 ,  G01S19/48 ,  G01S19/51

摘要： An amplifier for use in a buoyant cable antenna operable to receive signals within a frequency band includes: a first amplifier operable to provide amplified signals based on the received signals; a bandpass filter arranged to pass filtered signals within a first portion of the frequency band, the filtered signals being based on the amplified signals; an attenuator arranged in parallel with said bandpass filter and operable to attenuate signals within a second portion of the frequency band, the attenuated signals being based on the amplified signals; and a second amplifier operable to provide an amplified output including first amplified signals within the first portion of the frequency band and to provide second amplified signals within the second portion of the frequency band. The first amplified signals have a first gain, the second amplified signals have a second gain, and the first gain is more than the second gain.

摘要翻译： 用于可操作以在频带内接收信号的浮动电缆天线中的放大器包括：第一放大器，用于基于所接收的信号提供放大的信号; 带通滤波器，被布置成在所述频带的第一部分内传递经滤波的信号，所述滤波信号基于所述放大信号; 衰减器，其与所述带通滤波器并联布置并且可操作以衰减所述频带的第二部分内的信号，所述衰减信号基于所述放大的信号; 以及第二放大器，其可操作以提供包括在所述频带的所述第一部分内的第一放大信号的放大输出并且在所述频带的第二部分内提供第二放大信号。 第一放大信号具有第一增益，第二放大信号具有第二增益，第一增益大于第二增益。

公开(公告)号：US20120263650A1

公开(公告)日：2012-10-18

申请号：US13440092

申请日：2012-04-05

申请人： David A. Wink ,  Wilmarie Flores-Santana ,  S. Bruce King ,  Murali Krishna Cherukuri ,  James B. Mitchell

发明人： David A. Wink ,  Wilmarie Flores-Santana ,  S. Bruce King ,  Murali Krishna Cherukuri ,  James B. Mitchell

IPC分类号： C07D401/12 ,  A61K49/00 ,  A61K31/454 ,  A61P35/00 ,  C07D211/94 ,  A61K31/621

CPC分类号： C07D401/12 ,  A61K47/48061 ,  A61K47/545 ,  C07D211/94

摘要： Disclosed are nitroxide modified NSAID compounds of the formula (I) or a pharmaceutically acceptable salt or enantiomer thereof: in which R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and n are defined herein and pharmaceutical compositions thereof. Further disclosed is a method of treating or preventing various disorders, such as inflammation, cancer, diabetes, a cardiovascular disorder, weight gain, polyps, and/or chronic pain, in a patient comprising administering an effective amount of a compound or pharmaceutically acceptable salt or enantiomer of formula (I). A method of imaging the compound or pharmaceutically acceptable salt or enantiomer of formula (I) in the body of the animal is also provided.

摘要翻译： 公开了式（I）的硝基氧改性的NSAID化合物或其药学上可接受的盐或对映异构体：其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9，R 10，R 11和n如本文所定义 及其药物组合物。 进一步公开的是在患者中治疗或预防各种疾病，例如炎症，癌症，糖尿病，心血管疾病，体重增加，息肉和/或慢性疼痛的方法，包括给予有效量的化合物或药学上可接受的盐 或式（I）的对映异构体。 还提供了在动物体内成像式（I）的化合物或药学上可接受的盐或对映异构体的方法。

公开(公告)号：US08269496B2

公开(公告)日：2012-09-18

申请号：US12306514

申请日：2007-06-28

申请人： Sankaran Subramanian ,  Nallathamby Devasahayam ,  Janusz Koscielniak ,  James B. Mitchell ,  Murali Krishna Cherukuri

发明人： Sankaran Subramanian ,  Nallathamby Devasahayam ,  Janusz Koscielniak ,  James B. Mitchell ,  Murali Krishna Cherukuri

IPC分类号： G01V3/00

CPC分类号： G01R33/60

摘要： An electron paramagnetic resonance imaging system that includes means for continuously irradiating a sample with RF irradiation; means for imposing on the sample a sinusoidally varying magnetic field along with rotating gradients for spatial encoding; means for directly detecting signal data from the sample, without using field modulation, while irradiating the sample with RF radiation continuously, the means for directly detecting having means for sweeping the sinusoidally varying magnetic field; and means for processing the signal data, using means including a digital signal processor.

摘要翻译： 一种电子顺磁共振成像系统，包括用于用RF照射连续照射样品的装置; 用于对样本施加正弦变化的磁场以及用于空间编码的旋转梯度的装置; 用于在不用场调制的情况下直接检测来自样品的信号数据的装置，同时用RF辐射连续照射样品，用于直接检测的装置具有用于扫描正弦变化磁场的装置; 以及使用包括数字信号处理器的装置处理信号数据的装置。

公开(公告)号：US20110109313A1

公开(公告)日：2011-05-12

申请号：US12794695

申请日：2010-06-04

申请人： Sankaran Subramanian ,  Nallathamby Devasahayam ,  Janusz Koscielniak ,  James B. Mitchell ,  Murali K. Cherukuri

发明人： Sankaran Subramanian ,  Nallathamby Devasahayam ,  Janusz Koscielniak ,  James B. Mitchell ,  Murali K. Cherukuri

IPC分类号： G01R33/20

CPC分类号： G01R33/60

摘要： An electron paramagnetic resonance imaging system that includes means for continuously irradiating a sample with RF irradiation; means for imposing on the sample a sinusoidally varying magnetic field along with rotating gradients for spatial encoding; means for directly detecting signal data from the sample, without using field modulation, while irradiating the sample with RF radiation continuously, the means for directly detecting having means for sweeping the sinusoidally varying magnetic field; and means for transmitting, receiving and processing the signal data, using means including a digital signal processor.

摘要翻译： 一种电子顺磁共振成像系统，包括用于用RF照射连续照射样品的装置; 用于对样本施加正弦变化的磁场以及用于空间编码的旋转梯度的装置; 用于在不用场调制的情况下直接检测来自样品的信号数据的装置，同时用RF辐射连续照射样品，用于直接检测的装置具有用于扫描正弦变化磁场的装置; 以及用于使用包括数字信号处理器的装置发送，接收和处理信号数据的装置。

公开(公告)号：US5462946A

公开(公告)日：1995-10-31

申请号：US859622

申请日：1992-03-20

申请人： James B. Mitchell ,  Amram Samuni ,  William DeGraff ,  Stephen Hahn

发明人： James B. Mitchell ,  Amram Samuni ,  William DeGraff ,  Stephen Hahn

IPC分类号： A61K31/40 ,  A61K31/415 ,  A61K31/42 ,  A61K31/421 ,  A61K31/423 ,  A61K31/445 ,  A61P3/04 ,  A61P9/08 ,  A61P9/10 ,  A61P11/16 ,  A61P17/00 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D207/46 ,  C07D213/89 ,  C07D231/10 ,  C07D233/02 ,  C07D239/34 ,  C07D263/04 ,  C07D263/52 ,  C07D277/20 ,  C09K15/30 ,  A61K31/425 ,  A61K31/44 ,  A61K31/505 ,  A61K31/52

CPC分类号： A61K31/445 ,  A61K31/42 ,  A61K31/421

摘要： The instant invention is directed to the use of a biologically compatible composition, containing an effective amount of a metal independent nitroxide compound which is preferably represented by the formula ##STR1## wherein R.sub.1 is --CH.sub.3 ; R.sub.2 is --C.sub.2 H.sub.5, --C.sub.3 H.sub.7, --C.sub.4 H.sub.9, --C.sub.5 H.sub.11, --C.sub.6 H.sub.13, --CH.sub.2 --CH(CH.sub.3).sub.2, --CHCH.sub.3 C.sub.2 H.sub.5, or --(CH.sub.2).sub.7 --CH.sub.3, or wherein R.sub.1 and R.sub.2 together form spirocyclopentane, spirocyclohexane, spirocycloheptane, spirocyclooctane, 5-cholestane, or norbornane, R.sub.3 is --O. or --OH, or a physiologically acceptable salt thereof, and a pharmaceutically acceptable carrier, as antioxidants capable of protecting cells, tissues, organs, and whole organisms against the deleterious effects of harmful oxygen-derived species generated during oxidative stress.

摘要翻译： 本发明涉及使用含有有效量的金属独立的氮氧化合物的生物相容性组合物，其优选由式（I）表示，其中R 1是-CH 3; R2是-C2H5，-C3H7，-C4H9，-C5H11，-C6H13，-CH2-CH（CH3）2，-CHCH3C2H5或 - （CH2）7-CH3，或其中R1和R2一起形成螺环戊烷，螺环己烷，螺环己烷 ，螺环辛烷，5-胆甾烷或降冰片烷，R3为-O。 或-OH，或其生理上可接受的盐和药学上可接受的载体，作为能够保护细胞，组织，器官和整体生物的抗氧化剂免受氧化应激期间产生的有害氧衍生物质的有害影响。