公开(公告)号：US08546562B2

公开(公告)日：2013-10-01

申请号：US13457232

申请日：2012-04-26

申请人： James D. Crapo ,  Brian J. Day ,  Michael P. Trova ,  Polvina Jolicia F. Gauuan ,  Douglas B. Kitchen ,  Irwin Fridovich ,  Ines Batinic-Haberle

发明人： James D. Crapo ,  Brian J. Day ,  Michael P. Trova ,  Polvina Jolicia F. Gauuan ,  Douglas B. Kitchen ,  Irwin Fridovich ,  Ines Batinic-Haberle

IPC分类号： C07D487/22 ,  A01N55/02

CPC分类号： A61K31/555 ,  A61K31/409 ,  C07D487/22 ,  C09B47/00

摘要： The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.

公开(公告)号：US20110065679A1

公开(公告)日：2011-03-17

申请号：US12885198

申请日：2010-09-17

申请人： James D. Crapo ,  Brian J. Day ,  Michael P. Trova ,  Polvina Jolicia F. Gauuan ,  Douglas B. Kitchen ,  Irwin Fridovich ,  Ines Batinic-Haberle

发明人： James D. Crapo ,  Brian J. Day ,  Michael P. Trova ,  Polvina Jolicia F. Gauuan ,  Douglas B. Kitchen ,  Irwin Fridovich ,  Ines Batinic-Haberle

IPC分类号： A61K31/555 ,  A61P11/00 ,  A61P29/00

CPC分类号： A61K31/555 ,  A61K31/409 ,  C07D487/22 ,  C09B47/00

摘要： The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.

摘要翻译： 本发明一般涉及一种调节生理和病理过程的方法，特别涉及一种调节氧化剂细胞水平的方法，从而涉及这种氧化剂是参与者的过程。 本发明还涉及适用于这些方法的化合物和组合物。

公开(公告)号：US08217026B2

公开(公告)日：2012-07-10

申请号：US12885198

申请日：2010-09-17

申请人： James D. Crapo ,  Brian J. Day ,  Michael P. Trova ,  Polvina Jolicia F. Gauuan ,  Douglas B. Kitchen ,  Irwin Fridovich ,  Ines Batinic-Haberle

发明人： James D. Crapo ,  Brian J. Day ,  Michael P. Trova ,  Polvina Jolicia F. Gauuan ,  Douglas B. Kitchen ,  Irwin Fridovich ,  Ines Batinic-Haberle

IPC分类号： A01N55/02 ,  A01N43/36 ,  A61K31/40 ,  C07B47/00 ,  C07B487/22

CPC分类号： A61K31/555 ,  A61K31/409 ,  C07D487/22 ,  C09B47/00

摘要： The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.

摘要翻译： 本发明一般涉及一种调节生理和病理过程的方法，特别涉及一种调节氧化剂细胞水平的方法，从而涉及这种氧化剂是参与者的过程。 本发明还涉及适用于这些方法的化合物和组合物。