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    Compounds and methods for thiol-containing compound efflux and cancer treatment
    1.
    发明授权
    Compounds and methods for thiol-containing compound efflux and cancer treatment 有权
    含硫醇化合物外排和癌症治疗的化合物和方法

    公开(公告)号：US07790762B2

    公开(公告)日：2010-09-07

    申请号：US11280959

    申请日：2005-11-15

    申请人： Brian J. Day ,  Remy Kachadourian

    发明人： Brian J. Day ,  Remy Kachadourian

    IPC分类号： A61K31/4164 ,  C07D233/60

    CPC分类号： C07D233/70 ,  A61K31/35 ,  A61K31/353 ,  A61K31/37 ,  A61K31/428 ,  A61K31/47 ,  A61K31/635 ,  A61K2121/00 ,  C07D209/86 ,  C07D233/64 ,  C07D261/08 ,  C07D263/32 ,  C07D277/24 ,  C07D473/00

    摘要： Methods for therapy of cystic fibrosis and other conditions such as cancer are provided. The methods comprise one or more agents capable of increasing thiol-containing compound transport via a transporter system (i.e. ABC transporters such as MDR-1 or MRP-2) in cells. Other embodiments include the use of agents to modulate transport of thiol-containing compounds within the cell. Therapeutic methods involve the administration of such agents to a patient afflicted with cystic fibrosis, cancer and/or another condition responsive to stimulation of thiol-containing compound transport.

    摘要翻译： 提供了治疗囊性纤维化和其他病症如癌症的方法。 所述方法包括一种或多种能够通过转运体系（即，ABC转运体如MDR-1或MRP-2）在细胞中增加含硫醇化合物转运的试剂。 其它实施方案包括使用试剂来调节细胞内含硫醇化合物的转运。 治疗方法包括向患有囊性纤维化，癌症和/或对刺激含硫醇化合物转运反应的另一种病症的患者施用此类药物。

    Treatments based on discovery that nitric oxide synthase is a paraquat diaphorase
    3.
    发明授权
    Treatments based on discovery that nitric oxide synthase is a paraquat diaphorase 有权
    基于发现一氧化氮合酶是百草枯心肌黄酶的治疗

    公开(公告)号：US06231894B1

    公开(公告)日：2001-05-15

    申请号：US09421942

    申请日：1999-10-21

    申请人： Jonathan S. Stamler ,  Brian J. Day ,  Steven S. Gross ,  Owen W. Griffith

    发明人： Jonathan S. Stamler ,  Brian J. Day ,  Steven S. Gross ,  Owen W. Griffith

    IPC分类号： A61K3300

    CPC分类号： A61K31/44 ,  A61K31/00 ,  A61K31/223 ,  A61K31/4425 ,  A61K31/444 ,  A61K31/4985 ,  A61K33/00 ,  A61K31/22 ,  A61K2300/00

    摘要： Paraquat has been found to accept electrons from nitric oxide synthase (NOS) whereupon the reduced paraquat generates toxic O2− and prevents NOS from giving electrons to arginine and thereby inhibits NO production. This is generalized for compounds with a redox potential greater than nitric oxide synthase. The compounds inhibit nitric oxide synthase and kill cells including NOS by generating O2− and also by depriving the cells of the NO which they need. Applications include treating paraquat-induced injury and pathologically proliferating cells (tumors, restenosis benign prostatic hypertrophy, pulmonary hypertension, infective pathogens).

    摘要翻译： 已经发现百草枯接受来自一氧化氮​​合酶（NOS）的电子，随后还原的百草枯产生有毒的O 2 - 并且防止NOS向精氨酸发电，从而抑制NO产生。 这对于具有大于一氧化氮合酶的氧化还原电位的化合物是普遍的。 该化合物通过产生O2-抑制一氧化氮合酶并杀死包括NOS的细胞，并且还通过剥夺其所需的NO的细胞。 应用包括处理百草枯诱导的损伤和病理增殖细胞（肿瘤，再狭窄良性前列腺肥大，肺动脉高压，感染性病原体）。

    Methods for treatment of thiol-containing compound deficient conditions
    7.
    发明申请
    Methods for treatment of thiol-containing compound deficient conditions 审中-公开
    治疗含硫醇化合物缺乏症状的方法

    公开(公告)号：US20140162986A1

    公开(公告)日：2014-06-12

    申请号：US14180281

    申请日：2014-02-13

    申请人： Brian J. Day ,  Leonard W. Velsor

    发明人： Brian J. Day ,  Leonard W. Velsor

    IPC分类号： A61K31/635 ,  A61K31/60 ,  A61K31/606

    CPC分类号： A61K31/635 ,  A61K31/35 ,  A61K31/353 ,  A61K31/37 ,  A61K31/428 ,  A61K31/47 ,  A61K31/60 ,  A61K31/606 ,  A61K2121/00

    摘要： Methods for therapy of cystic fibrosis and other conditions are provided. The methods comprise one or more agents capable of increasing thiol-containing compound transport via a transporter system (i.e. ABC transporters such as MDR-1 or MRP-2) in cells. Other embodiments include the use of agents to modulate transport of thiol-containing compounds within the cell. Therapeutic methods involve the administration of such agents to a patient afflicted with cystic fibrosis and/or another condition responsive to stimulation of thiol-containing compound transport.

    摘要翻译： 提供了治疗囊性纤维化和其他病症的方法。 所述方法包括一种或多种能够通过转运体系（即，ABC转运体如MDR-1或MRP-2）在细胞中增加含硫醇化合物转运的试剂。 其它实施方案包括使用试剂来调节细胞内含硫醇化合物的转运。 治疗方法涉及向患有囊性纤维化的患者和/或对刺激含硫醇化合物转运反应的另一种病症的患者施用此类药剂。

    Methods for treatment of thiol-containing compound deficient conditions
    10.
    发明授权
    Methods for treatment of thiol-containing compound deficient conditions 有权
    治疗含硫醇化合物缺乏症状的方法

    公开(公告)号：US07498047B2

    公开(公告)日：2009-03-03

    申请号：US11211369

    申请日：2005-08-24

    申请人： Brian J. Day ,  Richard T. Sawyer ,  Lee S. Newman

    发明人： Brian J. Day ,  Richard T. Sawyer ,  Lee S. Newman

    IPC分类号： A61K35/42

    CPC分类号： A61K31/635 ,  A61K31/35 ,  A61K31/353 ,  A61K31/37 ,  A61K31/428 ,  A61K31/47 ,  A61K31/60 ,  A61K31/606 ,  A61K2121/00

    摘要： Methods for therapy of cystic fibrosis and other conditions are provided. The methods comprise one or more agents capable of increasing thiol-containing compound transport via a transporter system (i.e. ABC transporters such as MDR-1 or MRP-2) in cells. Other embodiments include the use of agents to modulate transport of thiol-containing compounds within the cell. Therapeutic methods involve the administration of such agents to a patient afflicted with cystic fibrosis and/or another condition responsive to stimulation of thiol-containing compound transport.

    摘要翻译： 提供了治疗囊性纤维化和其他病症的方法。 所述方法包括一种或多种能够通过转运体系（即，ABC转运体如MDR-1或MRP-2）在细胞中增加含硫醇化合物转运的试剂。 其它实施方案包括使用试剂来调节细胞内含硫醇化合物的转运。 治疗方法涉及向患有囊性纤维化的患者和/或对刺激含硫醇化合物转运反应的另一种病症的患者施用此类药剂。