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1.发明授权Ethyl nitrite as a gastrointestinal smooth muscle relaxant and diagnostic and therapeutic uses thereof 有权亚硝酸亚乙酯作为胃肠道平滑肌松弛剂及其诊断和治疗用途公开(公告)号：US07968533B2
公开(公告)日：2011-06-28
申请号：US11715594
申请日：2007-03-07
CPC分类号： A61K9/12 , A61K9/0073
摘要： The present invention provides compositions comprising a gas and a gastrointestinal smooth muscle relaxing agent comprising ethyl nitrite in a therapeutically effective amount. The present invention also provides methods of relaxing gastrointestinal smooth muscle, alleviating contraction or spasm of gastrointestinal smooth muscle to facilitate a diagnostic medical procedure and treating or preventing a gastrointestinal disorder using the compositions of the invention.
摘要翻译： 本发明提供了包含气体和包含治疗有效量的亚硝酸乙酯的胃肠平滑肌松弛剂的组合物。 本发明还提供了使用本发明的组合物缓和胃肠平滑肌，减轻胃肠平滑肌的收缩或痉挛以促进诊断医学过程和治疗或预防胃肠道疾病的方法。
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公开(公告)号：US20110003012A1
公开(公告)日：2011-01-06
申请号：US12677336
申请日：2008-09-08
IPC分类号： A61K33/26 , A61K31/04 , A61K33/00 , A61K31/198 , A61P7/04
CPC分类号： A61K31/04
摘要： A method for attenuating vasoconstriction in a patient with subarachnoid hemorrhage by administering to the patient a therapeutically effective amount of a compound which mediates an increase of bioactive nitric oxide in blood or tissue in the subarachnoid space to cause vasodilation in cerebral, carotid and basilar arteries after the administration of the compound, and wherein the administration of the compound does not reduce mean arterial blood pressure by more than 10%.
摘要翻译： 一种通过向患者施用治疗有效量的介导在蛛网膜下腔中的血液或组织中的生物活性一氧化氮增加的化合物以在脑，颈动脉和基底动脉中引起血管舒张的方法来减轻蛛网膜下腔出血患者的血管收缩的方法， 所述化合物的给药，其中所述化合物的给药不会使平均动脉血压降低10％以上。
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公开(公告)号：US20140314881A1
公开(公告)日：2014-10-23
申请号：US14318825
申请日：2014-06-30
CPC分类号： A01N1/0226 , A61K31/04 , A61K31/21 , A61K33/00
摘要： A body part is preserved using nitric oxide and/or a nitric oxide donor that does not directly release nitric oxide or a red blood cell nitrosylating agent, preferably ethyl nitrite to facilitate oxygen supply. A subject at risk for developing high altitude illness is administered a red blood nitrosylating agent in gaseous form that does not directly release nitric oxide, preferably ethyl nitrite.
摘要翻译： 使用不直接释放一氧化氮的一氧化氮和/或一氧化氮供体或红细胞亚硝酰化剂（优选亚硝酸乙酯）以促进氧供应来保存身体部分。 处于发展高原病风险的受试者服用不直接释放一氧化氮（优选亚硝酸亚乙酯）的气态形式的红血亚硝酰化剂。
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公开(公告)号：US20120201906A1
公开(公告)日：2012-08-09
申请号：US13394576
申请日：2010-07-16
CPC分类号： A01N1/0226 , A61K31/04 , A61K31/21 , A61K33/00
摘要： A body part is preserved using nitric oxide and/or a nitric oxide donor that does not directly release nitric oxide or a red blood cell nitrosylating agent, preferably ethyl nitrite to facilitate oxygen supply. A subject at risk for developing high altitude illness is administered a red blood nitrosylating agent in gaseous form that does not directly release nitric oxide, preferably ethyl nitrite.
摘要翻译： 使用不直接释放一氧化氮的一氧化氮和/或一氧化氮供体或红细胞亚硝酰化剂（优选亚硝酸乙酯）以促进氧供应来保存身体部分。 处于发展高原病风险的受试者服用不直接释放一氧化氮（优选亚硝酸亚乙酯）的气态形式的红血亚硝酰化剂。
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