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公开(公告)号:US5827879A
公开(公告)日:1998-10-27
申请号:US943474
申请日:1997-10-03
Applicant: William J. Ehlhardt , James E. Ray , John E. Toth
Inventor: William J. Ehlhardt , James E. Ray , John E. Toth
IPC: C07D307/83 , A61K31/34
CPC classification number: C07D307/83
Abstract: This invention provides certain substituted 2,3-dihydrobenzofurylsulfonamide derivatives and methods for using them in the treatment of susceptible neoplasms in mammals. Also provided are certain novel pharmaceutical formulations employing these benzenesulfonamide derivatives in combination with a carrier.
Abstract translation: 本发明提供某些取代的2,3-二氢苯并呋喃基磺酰胺衍生物及其用于治疗哺乳动物易感性肿瘤的方法。 还提供了使用这些苯磺酰胺衍生物与载体组合的某些新型药物制剂。
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公开(公告)号:USD399782S
公开(公告)日:1998-10-20
申请号:US076096
申请日:1997-09-02
Applicant: James E. Ray
Designer: James E. Ray
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公开(公告)号:USD510514S1
公开(公告)日:2005-10-11
申请号:US29199228
申请日:2004-02-11
Applicant: James E. Ray , Jeffrey A. Harkins
Designer: James E. Ray , Jeffrey A. Harkins
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公开(公告)号:USD399781S
公开(公告)日:1998-10-20
申请号:US75267
申请日:1997-08-29
Applicant: James E. Ray
Designer: James E. Ray
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公开(公告)号:US5521307A
公开(公告)日:1996-05-28
申请号:US837173
申请日:1992-02-18
Applicant: Jack W. Fisher , Lowell D. Hatfield , Richard C. Hoying , James E. Ray
Inventor: Jack W. Fisher , Lowell D. Hatfield , Richard C. Hoying , James E. Ray
IPC: A61K31/435 , A61P31/00 , A61P31/04 , C07D413/04 , C07D413/14 , C07D463/00 , C07D471/04 , C07B43/04
CPC classification number: C07D413/14 , C07D413/04 , Y02P20/55
Abstract: A chiral process for preparing compounds of the formula: ##STR1## from a compound of the formula: ##STR2## in which the compound formula (IV) is reacted with trimethylsilyl iodide to remove the chiral auxiliary at the 7-position and the carboxy protecting group. The process allows for the retention of the amino and carboxy protecting groups throughout the preparation of Compound IV. Also disclosed are novel intermediates.
Abstract translation: (IV)的化合物制备下式的化合物的手性方法:其中化合物式(IV)与三甲基甲硅烷基碘反应,以在7位上除去手性助剂 - 位和羧基保护基。 该方法允许在化合物IV的制备过程中保留氨基和羧基保护基团。 还公开了新型中间体。
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公开(公告)号:US5354778A
公开(公告)日:1994-10-11
申请号:US37954
申请日:1993-03-26
Applicant: James E. Ray , John E. Toth , J. Jeffry Howbert
Inventor: James E. Ray , John E. Toth , J. Jeffry Howbert
IPC: A61K31/17 , A61K31/64 , A61P35/00 , C07C311/60 , A61K31/18 , C07C311/16
CPC classification number: A61K31/64 , C07C311/60
Abstract: This invention provides certain N-phenyl-N'-substituted phenylsulfonylureas compounds, formulations, and a method for treating susceptible neoplasms in mammals using the sulfonylurea compounds.
Abstract translation: 本发明提供某些N-苯基-N'-取代的苯基磺酰脲类化合物,制剂以及使用磺酰脲类化合物治疗哺乳动物易感性肿瘤的方法。
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公开(公告)号:US6012250A
公开(公告)日:2000-01-11
申请号:US921230
申请日:1997-08-29
Applicant: James E. Ray
Inventor: James E. Ray
CPC classification number: A01G5/04
Abstract: A floral display holder has a hollow body with a frontal recess for receiving a water-absorbing foam, and a manual pump to draw water from a lower portion defining a liquid reservoir. The floral display holder has U-shaped clips to secure the foam generally against a floor surface of the recess. The water drawn with the pump is directed onto the foam, thereby replenishing the foam with additional water.
Abstract translation: 花卉展示支架具有中空体,其具有用于接收吸水泡沫的前部凹部,以及手动泵,其从限定液体储存器的下部抽取水。 花卉展示架具有U形夹子,以将泡沫大体固定在凹槽的地板表面上。 用泵抽出的水被引导到泡沫上,从而用额外的水补充泡沫。
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公开(公告)号:US5987814A
公开(公告)日:1999-11-23
申请号:US92613
申请日:1998-06-05
Applicant: James E. Ray
Inventor: James E. Ray
CPC classification number: A01G5/04 , A61G17/045
Abstract: A floral display holder to be used on a funeral casket has a hollow body with an inclining recess for receiving water-absorbing foams, and a manual pump to draw water from a lower portion defining a liquid reservoir. The floral display holder has U-shaped clips to secure the foams generally against an inclined floor surface of the recess. The water drawn with the pump is directed onto the foam, thereby replenishing the foam with additional water.
Abstract translation: 用于葬礼棺材的花卉展示架具有中空体,其具有用于接收吸水泡沫的倾斜凹槽,以及手动泵,其从限定液体储存器的下部抽取水。 花卉展示架具有U形夹子,以将泡沫固定在凹槽的倾斜地板表面上。 用泵抽出的水被引导到泡沫上,从而用额外的水补充泡沫。
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公开(公告)号:USD394828S
公开(公告)日:1998-06-02
申请号:US71797
申请日:1997-06-09
Applicant: James E. Ray
Designer: James E. Ray
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公开(公告)号:US5529999A
公开(公告)日:1996-06-25
申请号:US206806
申请日:1994-03-04
Applicant: James E. Ray , John E. Toth
Inventor: James E. Ray , John E. Toth
IPC: A61K31/495 , A61P35/00 , C07D241/44 , C07D403/12 , C07D405/12
CPC classification number: C07D403/12 , C07D241/44 , C07D405/12
Abstract: This invention provides certain sulfonamidoquinoxaline derivatives and methods for using them in the treatment of susceptible neoplasms in mammals. Also provided are certain novel pharmaceutical formulations employing these sulfonamidoquinoxaline derivatives, in combination with a carrier, diluent or excipient.
Abstract translation: 本发明提供某些磺酰氨基喹喔啉衍生物及其用于治疗哺乳动物易感性肿瘤的方法。 还提供了采用这些磺酰氨基喹喔啉衍生物与载体,稀释剂或赋形剂组合的某些新型药物制剂。
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