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    Method of using IL-11 for treating gingivitis
    2.
    发明授权
    Method of using IL-11 for treating gingivitis 失效
    使用IL-11治疗牙龈炎的方法

    公开(公告)号：US06270759B1

    公开(公告)日：2001-08-07

    申请号：US09337965

    申请日：1999-06-22

    Applicant: James Keith ,  Paul Schendel

    Inventor： James Keith ,  Paul Schendel

    IPC: A61K4500

    CPC classification number: A61K38/2073 ,  Y10S514/867 ,  Y10S514/885 ,  Y10S514/886

    Abstract: Provided by the present invention are methods of treating a variety of disorders including AIDS, arthritis (rheumatoid arthritis, osteoarthritis, spondyloarthropathies), antibiotic induced diarrheal diseases (Clostridium difficile), multiple sclerosis, osteoporosis, gingivitis, peptic ulcer disease, esophagitis, diabetes, retinitis, uveitis, reperfusion injury after myocardial infarction (MI) or cerebral vascular accident (CVA), aphthous ulcers (oral), atherosclerosis (plaque rupture), prevention of tumor metastases, asthma, preeclampsia, and allergic disorders such as rhinitis, conjunctivitis, and urticaria.

    Abstract translation: 本发明提供了治疗各种疾病的方法，包括AIDS，关节炎（类风湿性关节炎，骨关节炎，脊柱关节病），抗生素诱发的腹泻病（艰难梭菌），多发性硬化症，骨质疏松症，牙龈炎，消化性溃疡病，食道炎，糖尿病， 视网膜炎，葡萄膜炎，心肌梗死（MI）或脑血管意外（CVA），口腔溃疡（口腔），动脉粥样硬化（斑块破裂），预防肿瘤转移，哮喘，先兆子痫和过敏性疾病如鼻炎，结膜炎， 和荨麻疹。

    Topical formulation for delivery of interleukin-11
    3.
    发明申请
    Topical formulation for delivery of interleukin-11 审中-公开
    用于递送白细胞介素-11的局部制剂

    公开(公告)号：US20050129658A1

    公开(公告)日：2005-06-16

    申请号：US11050246

    申请日：2005-02-03

    Applicant: Nick Warne ,  Camille Bedrosian ,  James Keith ,  Ullrich Schwertschlag ,  Paul Schendel

    Inventor： Nick Warne ,  Camille Bedrosian ,  James Keith ,  Ullrich Schwertschlag ,  Paul Schendel

    IPC: A61K38/00 ,  A61K38/19 ,  A61K38/20

    CPC classification number: A61K38/2073 ,  A61K9/0031 ,  A61K9/0056 ,  A61K9/006

    Abstract: Provided by the present invention are topical formulations of Interleukin-11 and methods for treating a variety of disorders, including inflammatory bowel diseases (e.g., Crohn's disease, ulcerative colitis, indeterminate colitis, and infectious colitis), mucositis (e.g., oral mucositis, gastrointestinal mucositis, nasal mucositis, and proctitis), necrotizing enterocolitis, inflammatory skin disorders (e.g., psoriasis, atopic dermatitis, and contact hypersensitivity), aphthous ulcers, pharyngitis, esophagitis, peptic ulcers, gingivitis, periodontitis, and ocular diseases (e.g., conjunctivitis, retinitis, and uveitis).

    Abstract translation: 本发明提供了白介素-11的局部制剂和用于治疗各种疾病的方法，包括炎症性肠病（例如克罗恩病，溃疡性结肠炎，不确定性结肠炎和感染性结肠炎），粘膜炎（例如口腔粘膜炎，胃肠道 肠粘膜炎和直肠炎），坏死性小肠结肠炎，炎性皮肤病（例如银屑病，特应性皮炎和接触性超敏反应），口疮性溃疡，咽炎，食管炎，消化性溃疡，牙龈炎，牙周炎和眼部疾病（例如结膜炎， 视网膜炎和葡萄膜炎）。

    Method of using IL-11 for inflammation associated with acute pancreatitis
    4.
    发明授权
    Method of using IL-11 for inflammation associated with acute pancreatitis 失效
    使用IL-11与急性胰腺炎相关的炎症的方法

    公开(公告)号：US06274135B1

    公开(公告)日：2001-08-14

    申请号：US09337968

    申请日：1999-06-22

    Applicant: James Keith ,  Paul Schendel

    Inventor： James Keith ,  Paul Schendel

    IPC: A61K3820

    CPC classification number: A61K38/2073 ,  A61K38/00 ,  Y10S514/885 ,  A61K2300/00

    Abstract: Provided by the present invention are methods of treating a variety of disorders including AIDS, arthritis (rheumatoid arthritis, osteoarthritis, spondyloarthropathies), antibiotic induced diarrheal diseases (Closbidium difficile), multiple sclerosis, osteoporosis, gingivitis, peptic ulcer disease, esophagitis, diabetes, retinitis, uveitis, reperfusion injury after myocardial infarction (MI) or cerebral vascular accident (CVA), aphthous ulcers (oral), atherosclerosis (plaque rupture), prevention of tumor metastases, asthma, preeclampsia, acute pancreatitis, psoriasis, infertility and allergic disorders such as rhinitis, conjunctivitis, and urticaria.

    Abstract translation: 本发明提供了治疗各种疾病的方法，包括AIDS，关节炎（类风湿性关节炎，骨关节炎，脊柱关节病），抗生素诱发的腹泻病（艰难梭菌），多发性硬化症，骨质疏松症，牙龈炎，消化性溃疡病，食道炎，糖尿病， 视网膜炎，葡萄膜炎，心肌梗死（MI）或脑血管意外（CVA），口腔溃疡（口腔），动脉粥样硬化（斑块破裂），预防肿瘤转移，哮喘，先兆子痫，急性胰腺炎，牛皮癣，不育症和过敏性疾病的再灌注损伤 如鼻炎，结膜炎和荨麻疹。

    Method of using IL-11 for treating antibiotic induced diarrhea
    5.
    发明授权
    Method of using IL-11 for treating antibiotic induced diarrhea 失效
    使用IL-11治疗抗生素诱发腹泻的方法

    公开(公告)号：US5948402A

    公开(公告)日：1999-09-07

    申请号：US892407

    申请日：1997-07-15

    Applicant: James Keith ,  Paul Schendel

    Inventor： James Keith ,  Paul Schendel

    IPC: A61K38/00 ,  A61K38/20 ,  A61P1/00 ,  A61P1/02 ,  A61P3/08 ,  A61P9/00 ,  A61P9/10 ,  A61P11/08 ,  A61P25/00 ,  A61P27/02 ,  A61P27/16 ,  A61P29/00 ,  A61P31/12 ,  A61P31/18 ,  A61P35/00 ,  A61P43/00

    CPC classification number: A61K38/2073 ,  Y10S514/867 ,  Y10S514/885 ,  Y10S514/886

    Abstract: Provided by the present invention are methods of treating a variety of disorders including AIDS, arthritis (rheumatoid arthritis, osteoarthritis, spondyloarthropathies), antibiotic induced diarrheal diseases (Clostridium difficile), multiple sclerosis, osteoporosis, gingivitis, peptic ulcer disease, esophagitis, diabetes, retinitis, uveitis, reperfusion injury after myocardial infarction (MI) or cerebral vascular accident (CVA), aphthous ulcers (oral), atherosclerosis (plaque rupture), prevention of tumor metastases, asthma, preeclampsia, and allergic disorders such as rhinitis, conjunctivitis, and urticaria.

    Abstract translation: 本发明提供了治疗各种疾病的方法，包括AIDS，关节炎（类风湿性关节炎，骨关节炎，脊柱关节病），抗生素诱发的腹泻病（艰难梭菌），多发性硬化症，骨质疏松症，牙龈炎，消化性溃疡病，食道炎，糖尿病， 视网膜炎，葡萄膜炎，心肌梗死（MI）或脑血管意外（CVA），口腔溃疡（口腔），动脉粥样硬化（斑块破裂），预防肿瘤转移，哮喘，先兆子痫和过敏性疾病如鼻炎，结膜炎， 和荨麻疹。

    Method of using IL-11 for treating spondyloarthropies
    6.
    发明授权
    Method of using IL-11 for treating spondyloarthropies 失效
    使用IL-11治疗脊柱关节病的方法

    公开(公告)号：US5679339A

    公开(公告)日：1997-10-21

    申请号：US495724

    申请日：1995-06-27

    Applicant: James Keith ,  Paul Schendel

    Inventor： James Keith ,  Paul Schendel

    IPC: A61K38/00 ,  A61K38/20 ,  A61P1/00 ,  A61P1/02 ,  A61P3/08 ,  A61P9/00 ,  A61P9/10 ,  A61P11/08 ,  A61P25/00 ,  A61P27/02 ,  A61P27/16 ,  A61P29/00 ,  A61P31/12 ,  A61P31/18 ,  A61P35/00 ,  A61P43/00 ,  A61K45/05 ,  C07K17/00

    CPC classification number: A61K38/2073 ,  Y10S514/867 ,  Y10S514/885 ,  Y10S514/886

    Abstract: Provided by the present invention are methods of treating a variety of disorders including AIDS, arthritis (rheumatoid arthritis, osteoarthritis, spondyloarthropathies), antibiotic induced diarrheal diseases (Clostridium difficile), multiple sclerosis, osteoporosis, gingivitis, peptic ulcer disease, esophagitis, diabetes, retinitis, uveitis, reperfusion injury after myocardial infarction (MI) or cerebral vascular accident (CVA), aphthous ulcers (oral), atherosclerosis (plaque rupture), prevention of minor metastases, asthma, preeclampsia, and allergic disorders such as rhinitis, conjunctivitis, and urticaria.

    Abstract translation: 本发明提供了治疗各种疾病的方法，包括AIDS，关节炎（类风湿性关节炎，骨关节炎，脊柱关节病），抗生素诱发的腹泻病（艰难梭菌），多发性硬化症，骨质疏松症，牙龈炎，消化性溃疡病，食道炎，糖尿病， 视网膜炎，葡萄膜炎，心肌梗死（MI）或脑血管意外（CVA），口腔溃疡（口腔），动脉粥样硬化（斑块破裂），预防轻微转移，哮喘，先兆子痫和过敏性疾病如鼻炎，结膜炎， 和荨麻疹。

    Methods of treating rheumatoid arthritis using NF-kB inhibitors
    9.
    发明申请
    Methods of treating rheumatoid arthritis using NF-kB inhibitors 审中-公开
    使用NF-kB抑制剂治疗类风湿关节炎的方法

    公开(公告)号：US20050113405A1

    公开(公告)日：2005-05-26

    申请号：US10947900

    申请日：2004-09-23

    Applicant: Douglas Harnish ,  Christopher Chadwick ,  James Keith

    Inventor： Douglas Harnish ,  Christopher Chadwick ,  James Keith

    IPC: A61K31/416 ,  A61K31/473

    CPC classification number: A61K31/416 ,  A61K31/473

    Abstract: The present invention concerns a method of treating rheumatoid arthritis by diagnosing that a person is in need of treatment for rheumatoid arthritis and administering a therapeutically effective amount of a ligand which modulates NF-kB transcription factor by interaction with estrogen receptor ER-α, estrogen receptor ER-β, or both ER-α and ER-β estrogen receptors with a substantial absence of creatine kinase stimulation. In certain embodiments, the administration is with a substantial absence of uterotropic activity.

    Abstract translation: 本发明涉及一种通过诊断人类需要治疗类风湿性关节炎并且通过与雌激素受体ER-α，雌激素受体相互作用来施用治疗有效量的调节NF-kB转录因子的配体来治疗类风湿性关节炎的方法 ER-β或ER-α和ER-β雌激素受体，而肌酸激酶刺激基本上不存在。 在某些实施方案中，施用基本上不存在子活性。

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