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    Direct Compression Formulation and Process
    1.
    发明申请
    Direct Compression Formulation and Process 审中-公开
    直接压缩配方和工艺

    公开(公告)号：US20080193529A1

    公开(公告)日：2008-08-14

    申请号：US11916490

    申请日：2006-06-08

    申请人： James Kowalski ,  Jay Parthiban Lakshman ,  Arun Patel

    发明人： James Kowalski ,  Jay Parthiban Lakshman ,  Arun Patel

    IPC分类号： A61K9/20 ,  A61K31/4439 ,  A61K9/14 ,  A61K31/40

    CPC分类号： A61K31/40 ,  A61K31/4439 ,  A61K45/06 ,  A61K2300/00

    摘要： Dipeptidylpeptidase IV inhibitor (herein referred to as DPP-IV) that may be 98.5-100% pure is a high-dose drug capable of being directly compressed with a glitazone and specific excipients into sold form dosage forms, such as tablets and capsules having desired, hardness, disintegrating ability and acceptable dissolution characteristics. DPP-IV is not inherently compressible and thus presents formulation problems. Excipients used in the formulation enhance the flow and compaction properties of the drug and tableting mix. Optimal flow contributes to uniform die fill and weight control. The binder used ensures sufficient cohesive properties that allow DPP-IV to be compressed using the direct compression method. The tablets produced provide an acceptable in vitro dissolution profile.

    摘要翻译： 可以为98.5-100％纯度的二肽基肽酶IV抑制剂（在本文中称为DPP-IV）是能够用格列酮和特定赋形剂直接压制成销售形式的剂型的高剂量药物，例如具有期望的片剂和胶囊 ，硬度，崩解性和可接受的溶解特性。 DPP-IV不是固有的可压缩性，因此呈现配方问题。 制剂中使用的赋形剂增强了药物和压片混合物的流动和压实性能。 最佳流量有助于均匀的模头填充和重量控制。 使用的粘合剂确保足够的内聚性质，使DPP-IV能够使用直接压缩方法进行压缩。 所制备的片剂提供可接受的体外溶出曲线。

    Method of purifying tpa or plasminogen activator using a tripeptide of the formula: -X-Y-argininal wherein X and Y are selected from the group consisting of pro,phe,trp and tyr
    3.
    发明授权
    Method of purifying tpa or plasminogen activator using a tripeptide of the formula: -X-Y-argininal wherein X and Y are selected from the group consisting of pro,phe,trp and tyr 失效
    使用下式的三肽纯化tpa或纤溶酶原激活物的方法：-X-Y-精氨酸，其中X和Y选自由pro，phe，trp和tyr组成的组

    公开(公告)号：US5141862A

    公开(公告)日：1992-08-25

    申请号：US510333

    申请日：1990-04-17

    申请人： Arun Patel ,  A. Hirotoshi Nishikawa

    发明人： Arun Patel ,  A. Hirotoshi Nishikawa

    IPC分类号： C12N9/72

    CPC分类号： C12N9/6459 ,  C12Y304/21069

    摘要： A method for purifying tPA or a plasminogen activator having an active site resembling that of tPA from an impure solution thereof which comprises contacting the impure solution with a solid support having bound thereto a tripeptide of the formula: -X-Y-argininal, wherein X and Y are amino acids selected from the group consisting of pro, phe, trp and tyr. The method is also used with a tripeptide of the formula: -phe-Y-argininal, wherein Y is selected from the group consisting of phe, pro, trp, tyr, val, ile and glu(PEA).

    摘要翻译： 一种用于从其不纯溶液中纯化具有类似于tPA活性位点的tPA或纤溶酶原激活物的方法，其包括使不纯溶液与固定有结合式-XY-精氨酸的三肽的固体支持物接触，其中X和Y 是选自pro，phe，trp和tyr的氨基酸。 该方法还与下式的三肽一起使用：-he-Y-精氨酸，其中Y选自phe，pro，trp，tyr，val，ile和glu（PEA）。

    COMPUTING MACHINE
    4.
    发明申请
    COMPUTING MACHINE 审中-公开
    计算机

    公开(公告)号：US20080092146A1

    公开(公告)日：2008-04-17

    申请号：US11869270

    申请日：2007-10-09

    申请人： Paul Chow ,  Christopher Madill ,  Arun Patel ,  Manuel Saldana De Fuentes

    发明人： Paul Chow ,  Christopher Madill ,  Arun Patel ,  Manuel Saldana De Fuentes

    IPC分类号： G06F15/17

    CPC分类号： G06F15/173

    摘要： An architecture for a scalable computing machine built using configurable processing elements, such as FPGAs, is provided. The machine can enable implementation of large scale computing applications using a heterogeneous combination of hardware accelerators and embedded microprocessors spread across many FPGAs, all interconnected by a flexible communication network structure.

    摘要翻译： 提供了一种使用诸如FPGA之类的可配置处理元件构建的可扩展计算机的架构。 该机器可以实现大规模计算应用程序，使用散布在许多FPGA中的硬件加速器和嵌入式微处理器的异构组合，所有这些FPGA都通过灵活的通信网络结构进行互连。

    High frequency, large bandwidth balun and method of manufacturing
    5.
    发明授权
    High frequency, large bandwidth balun and method of manufacturing 有权
    高频，大带宽平衡 - 不平衡变换和制造方法

    公开(公告)号：US06590469B1

    公开(公告)日：2003-07-08

    申请号：US09698982

    申请日：2000-10-27

    申请人： Arun Patel

    发明人： Arun Patel

    IPC分类号： H03H742

    CPC分类号： H03H7/42 ,  H01F27/06 ,  H01F30/02

    摘要： A high frequency, large bandwidth electronic device for transforming balanced/unbalanced electrical signals. In one embodiment, the device comprises an auto-transformer mounted on substrate interposed between the balanced and unbalanced port so as minimize parasitic losses. Bonded bi-filar wire is wound around the auto-transformer core which facilitates a low, balanced leakage inductance thereby further enhancing device bandwidth. A method of manufacturing the aforementioned electronic device is also disclosed.

    摘要翻译： 用于转换平衡/不平衡电信号的高频大带宽电子设备。 在一个实施例中，该装置包括安装在介于平衡端口和不平衡端口之间的基板上的自动变压器，从而最小化寄生损耗。 接合的双丝线缠绕在自动变压器铁芯上，这有助于低平衡的漏电感，从而进一步提高器件带宽。 还公开了制造上述电子设备的方法。