公开(公告)号：US20110028551A1

公开(公告)日：2011-02-03

申请号：US12988026

申请日：2009-04-15

Applicant: Daniel Levin ,  James Luchi

Inventor： Daniel Levin ,  James Luchi

IPC: A61K31/19 ,  C07C51/347

CPC classification number: C07D307/04

Abstract: The present invention is directed to a process for the preparation of the saponification products of lactones, preferably three- to eight-membered lactones. The present invention is also directed to a process for the preparation of compounds having general formula (I): wherein M is selected from the group consisting of cationic species, preferably metal cations (even more preferably Na), from a compound having the formula (II): comprising reacting a compound having formula (II) with a suitable hydroxide salt (M-OH) (III) such as, preferably, sodium hydroxide, in an aqueous medium. The reaction preferably utilizes a continuous process method for the substantial consumption of reagent and continuous, semi-continuous, and/or batch-wise processing for final consumption of reagent.

Abstract translation: 本发明涉及制备内酯，优选三至八元内酯的皂化产物的方法。 本发明还涉及制备具有通式（I）的化合物的方法：其中M选自具有式（I）的化合物的阳离子种类，优选金属阳离子（甚至更优选Na） II）：包括在水性介质中使具有式（II）的化合物与合适的氢氧化物盐（M-OH）（III），例如优选氢氧化钠反应。 该反应优选利用连续的方法来大量消耗试剂和连续，半连续和/或分批处理以最终消耗试剂。

公开(公告)号：US20140199397A1

公开(公告)日：2014-07-17

申请号：US14124523

申请日：2012-06-08

Applicant: Daniel Levin ,  James Luchi

Inventor： Daniel Levin ,  James Luchi

IPC: A61K9/14 ,  A61K31/327

CPC classification number: A61K9/14 ,  A61K8/0241 ,  A61K8/38 ,  A61K9/0014 ,  A61K31/327 ,  A61K47/02 ,  A61K47/10 ,  A61K47/32 ,  A61K47/36 ,  A61K2800/412

Abstract: The present invention relates to the manufacture of microparticle benzoyl peroxide. The process of the invention provides for an aqueous slurry of USP benzoyl peroxide, optionally containing additives, being processed via microfluidization technology. The process comprises forcing a slurry of benzoyl peroxide at high pressure through a narrow channel designed to produce high shear, thereby achieving primary particle size reduction in addition to de-agglomeration.

Abstract translation: 本发明涉及过氧化苯甲酰微粒的制造。 本发明的方法提供了通过微流化技术加工的USP过氧化苯甲酰的含水浆料，任选地含有添加剂。 该方法包括通过设计成产生高剪切的窄通道强迫高压过氧化苯甲酸浆料，从而除了去附聚之外还实现一次粒度降低。

公开(公告)号：US08524944B2

公开(公告)日：2013-09-03

申请号：US12988026

申请日：2009-04-15

Applicant: Daniel Levin ,  James Luchi

Inventor： Daniel Levin ,  James Luchi

IPC: C07C59/01

CPC classification number: C07D307/04

Abstract: The present invention is directed to a process for the preparation of the saponification products of lactones, preferably three- to eight-membered lactones. The present invention is also directed to a process for the preparation of compounds having general formula (I): wherein M is selected from the group consisting of cationic species, preferably metal cations (even more preferably Na), from a compound having the formula (II): comprising reacting a compound having formula (II) with a suitable hydroxide salt (M-OH) (III) such as, preferably, sodium hydroxide, in an aqueous medium. The reaction preferably utilizes a continuous process method for the substantial consumption of reagent and continuous, semi-continuous, and/or batch-wise processing for final consumption of reagent.

Abstract translation: 本发明涉及制备内酯，优选三至八元内酯的皂化产物的方法。 本发明还涉及制备具有通式（I）的化合物的方法：其中M选自具有式（I）的化合物的阳离子种类，优选金属阳离子（甚至更优选Na） II）：包括在水性介质中使具有式（II）的化合物与合适的氢氧化物盐（M-OH）（III），例如优选氢氧化钠反应。 该反应优选利用连续的方法来大量消耗试剂和连续，半连续和/或分批处理以最终消耗试剂。

公开(公告)号：US08410304B2

公开(公告)日：2013-04-02

申请号：US12905767

申请日：2010-10-15

Applicant: James Luchi ,  Daniel Levin

Inventor： James Luchi ,  Daniel Levin

IPC: C07C69/66

CPC classification number: C07C51/09 ,  C07C51/412 ,  C07C59/01

Abstract: Disclosed herein are processes for preparing aqueous γ-hydroxybutyrate having a pH of about 8 or less (upon reaching equilibrium). The disclosed processes include both continuous processes and batch processes wherein the ratio of reactants is controlled to provide the product at the desired pH.

Abstract translation: 本文公开了具有约8或更低（达到平衡）pH值的γ-羟基丁酸水溶液的方法。 所公开的方法包括连续方法和分批方法，其中控制反应物的比例以将产物提供在所需pH。

公开(公告)号：US20110034727A1

公开(公告)日：2011-02-10

申请号：US12905767

申请日：2010-10-15

Applicant: James Luchi ,  Daniel Levin

Inventor： James Luchi ,  Daniel Levin

IPC: C07C51/12

CPC classification number: C07C51/09 ,  C07C51/412 ,  C07C59/01

Abstract: Disclosed herein are processes for preparing aqueous γ-hydroxybutyrate having a pH of about 8 or less (upon reaching equilibrium). The disclosed processes include both continuous processes and batch processes wherein the ratio of reactants is controlled to provide the product at the desired pH.

Abstract translation: 本文公开了具有约8或更低（达到平衡）pH值的γ-羟基丁酸水溶液的方法。 所公开的方法包括连续方法和分批方法，其中控制反应物的比例以将产物提供在所需pH。