公开(公告)号：US20220409557A1

公开(公告)日：2022-12-29

申请号：US17716932

申请日：2022-04-08

Applicant: James Martin Swanson

Inventor： James Martin Swanson

IPC: A61K31/137 ,  A61K9/48 ,  A61K31/4458 ,  A61K31/165 ,  A61K31/407 ,  A61K31/16 ,  A61K31/138 ,  A61K31/4168 ,  A61K31/5375 ,  A61K31/55 ,  A61K31/135

Abstract: It is proposed that dissipation of relative benefit during long-term treatment is due to long-term tolerance to stimulant medications. To improve adherence and persistence of medication use, it is advantageous to develop medications that are not undermined by long-term tolerance. Disclosed herein in certain implementations are formulations and methods relating to an alternative formulation of medication for the treatment of ADHD based on two principles: (a) retaining the initial immediate-release component of controlled-release formulations that targets a neural mechanism, which elicits acute tolerance, and (b) replacing the subsequent sustained-release component with a medication that maintains the initial benefit by targeting a different neural mechanism does not elicit tolerance, thus allowing more time for acute tolerance elicited by the initial bolus dose of stimulant medication to dissipate completely each day and avoid carry-over and accumulation that results in long-term tolerance.

公开(公告)号：US20190125215A1

公开(公告)日：2019-05-02

申请号：US16174940

申请日：2018-10-30

Applicant: James Martin Swanson ,  Robert Clay Isenhart

Inventor： James Martin Swanson ,  Robert Clay Isenhart

IPC: A61B5/107 ,  A61B5/00

Abstract: Systems and methods use a three-dimensional snapshot of an infant, child, adolescent, or adult where the subject may have bent legs and an unaligned head position, to provide an estimate of human length. The system identifies anatomical features from the digital information and generates a virtual skeleton. The cumulative distances between pseudo-joints of the virtual skeleton provide an estimate of human length. Comparing length estimates from multiple three-dimensional snapshots of the same individual acquired over time provide an indication of growth of the infant, child, or adolescent. Daily estimates of length can detect growth faltering sooner than less frequent estimates of length, which can lead to timely intervention.