公开(公告)号：US20080260657A1

公开(公告)日：2008-10-23

申请号：US11574083

申请日：2005-08-22

Applicant: James Matthew Butler ,  Angus Harry Forster ,  James Edon Patterson ,  John Peter Warr

Inventor： James Matthew Butler ,  Angus Harry Forster ,  James Edon Patterson ,  John Peter Warr

IPC: A61K9/12

CPC classification number: A61K9/146 ,  A61K9/008

Abstract: Drug substance for use in a pharmaceutical formulation may be prepared by a process which process comprises co-milling a suspension of the drug substance and a pharmaceutically acceptable polymer in a liquid propellant.

Abstract translation: 用于药物制剂的药物物质可以通过一种方法制备，该方法包括将液体推进剂中的药物物质和药学上可接受的聚合物的悬浮液共研磨。

公开(公告)号：US08352379B2

公开(公告)日：2013-01-08

申请号：US10203743

申请日：2001-01-29

Applicant: Nicholas Fulton ,  James Matthew Butler ,  Mark Anthony Curtis ,  David Parrott ,  Miles Jonathan Whitehead ,  Hui Wu

Inventor： Nicholas Fulton ,  James Matthew Butler ,  Mark Anthony Curtis ,  David Parrott ,  Miles Jonathan Whitehead ,  Hui Wu

IPC: G06F17/00

CPC classification number: H04L9/3247 ,  G06F21/10 ,  G06F2211/008 ,  G06F2221/2115 ,  G06Q20/401

Abstract: There is provided a method of, computer programs for and apparatus for providing and accessing digital content such as a news item. A news provider generates a news item, creates a digitally signed version of the news item and packages them together with a digital certificate issued by a certificate authority containing the public key required to decrypt the digitally signed version. The package is posted to a server and is transmitted, or made available or transmission, over a public data network together with a computer program for verifying the news item. A receiving party receives, over the public data network, the package at a client device and is provided with means for launching, and if necessary first downloading, the verifying program. The verifying program uses the public key contained in the certificate to verify the digitally signed news item. Before being first used to verify a news item, the verifying program receives a shared secret from the receiving party which is stored locally to the client device and is used by the verifying program to confirm that it performed the verification process.

公开(公告)号：US08092785B2

公开(公告)日：2012-01-10

申请号：US11574083

申请日：2005-08-22

Applicant: James Matthew Butler ,  Angus Harry Forster ,  James Edon Patterson ,  John Peter Warr

Inventor： James Matthew Butler ,  Angus Harry Forster ,  James Edon Patterson ,  John Peter Warr

IPC: A61K9/00 ,  A61K9/12 ,  A61K9/14

CPC classification number: A61K9/146 ,  A61K9/008

Abstract: Drug substance for use in a pharmaceutical formulation may be prepared by a process which process comprises co-milling a suspension of the drug substance and a pharmaceutically acceptable polymer in a liquid propellant.

Abstract translation: 用于药物制剂的药物物质可以通过一种方法制备，该方法包括将液体推进剂中的药物物质和药学上可接受的聚合物的悬浮液共研磨。

公开(公告)号：US5985326A

公开(公告)日：1999-11-16

申请号：US952938

申请日：1998-02-06

Applicant: James Matthew Butler

Inventor： James Matthew Butler

IPC: A61K9/14 ,  A61K9/10 ,  A61K47/32 ,  A61K47/38

CPC classification number: A61K9/146

Abstract: Solid dispersions of poorly soluble drugs, such as (6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione and (+)-N-[1-(adamantanmethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl]-N'-phenylurea, methods of preparing the solid dispersions, and use of the solid dispersions in pharmaceutical compositions are disclosed.

Abstract translation: PCT No.PCT / EP96 / 02299 Sec。 371日期1998年2月6日 102（e）1998年2月6日PCT PCT 1996年5月30日PCT公布。 公开号WO96 / 38131 日期1996年12月5日难溶性药物如（6R，12aR）-2,3,6,7,12,12a-六氢-2-甲基-6-（3,4-亚甲二氧基苯基） - 吡嗪并[ 2'，1'：6,1]吡啶并[3,4-b]吲哚-1,4-二酮和（+） - N- [1-（金刚烷甲基）-2,4-二氧代-5-苯基-2 ，3,4,5-四氢-1H-1,5-苯并二氮杂-3-基] -N'-苯基脲，制备固体分散体的方法以及在药物组合物中使用固体分散体。