公开(公告)号：US20100196415A1

公开(公告)日：2010-08-05

申请号：US12701339

申请日：2010-02-05

申请人： James W. DAVIS ,  Howard Allen KETELSON ,  David L. MEADOWS ,  John C. BAKER

发明人： James W. DAVIS ,  Howard Allen KETELSON ,  David L. MEADOWS ,  John C. BAKER

IPC分类号： A61K31/736 ,  C09F1/04 ,  A61P27/02

CPC分类号： A61K36/48 ,  A61K9/0048 ,  A61K47/36 ,  C08B37/0003 ,  C08B37/0096

摘要： The present invention relates to processes for purifying guar comprising combining borate and guar in an aqueous solution and treating the aqueous solution with an organic solvent to induce precipitation of purified guar. Another embodiment of the present invention is directed to ophthalmic formulations comprising purified guar produced by the processes described.

摘要翻译： 本发明涉及净化瓜尔胶的方法，包括在水溶液中混合硼酸盐和瓜尔胶，并用有机溶剂处理水溶液以诱导纯化的瓜尔胶的沉淀。 本发明的另一个实施方案涉及包含通过所述方法制备的纯化瓜尔胶的眼用制剂。

公开(公告)号：US20090270345A1

公开(公告)日：2009-10-29

申请号：US12429942

申请日：2009-04-24

申请人： Howard Allen KETELSON ,  James W. DAVIS ,  David L. MEADOWS

发明人： Howard Allen KETELSON ,  James W. DAVIS ,  David L. MEADOWS

IPC分类号： A61K31/715 ,  A61P27/02

CPC分类号： A61K47/26 ,  A61K9/0048 ,  A61K31/08 ,  A61K31/736 ,  A61K47/02 ,  A61K47/10 ,  A61K47/36

摘要： The present invention relates to artificial tear formulations and ophthalmic formulations suitable for drug delivery. The formulations comprise galactomannans such as guar or hydroxypropyl guar and a borate source such as boric acid. The formulations further comprise a cis-diol such as sorbitol that interferes with the cross-linking of galactomannan and borate. Optionally, the formulations are substantially free of divalent cations.

摘要翻译： 本发明涉及适于药物递送的人造泪液制剂和眼用制剂。 制剂包含半乳甘露聚糖，例如瓜尔胶或羟丙基瓜尔胶，硼酸盐如硼酸。 制剂还包含干扰半乳甘露聚糖和硼酸盐的交联的顺式二醇如山梨糖醇。 任选地，制剂基本上不含二价阳离子。

公开(公告)号：US20090253800A1

公开(公告)日：2009-10-08

申请号：US12410513

申请日：2009-03-25

申请人： Howard Allen KETELSON ,  Ryan DESOUSA ,  Nissanke L. DASSANAYAKE ,  Mary E. LUCK

发明人： Howard Allen KETELSON ,  Ryan DESOUSA ,  Nissanke L. DASSANAYAKE ,  Mary E. LUCK

IPC分类号： A01N33/12 ,  A01P1/00

CPC分类号： A61L12/143 ,  A61L12/14 ,  A61L12/145

摘要： Methods of inhibiting the uptake of cationic biocides into medical devices such as contact lenses and implants are described. Methods of stabilizing emulsions containing cationic biocides are also described. In particular, the present invention provides for the use of polymers acting as labile anionic polyelectrolytes to reversibly bind cationic biocides. The reversible binding can reduce the deleterious effects of cationic biocides while maintaining biocidal activity. Preferred polymers include galactomannan and polyvinyl alcohol.

摘要翻译： 描述了抑制阳离子杀生物剂吸收到医疗装置如隐形眼镜和植入物中的方法。 还描述了稳定含有阳离子杀生物剂的乳液的方法。 特别地，本发明提供了用作不稳定阴离子聚电解质的聚合物可逆地结合阳离子杀生物剂的用途。 可逆结合可以降低阳离子杀生物剂的有害作用，同时保持杀生物活性。 优选的聚合物包括半乳甘露聚糖和聚乙烯醇。