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    POLYALKYLENE OXIDE POLYQUATERNARY AMMONIUM BIOCIDES
    5.
    发明申请
    POLYALKYLENE OXIDE POLYQUATERNARY AMMONIUM BIOCIDES 有权
    聚亚烷基氧化物多环芳烃生物

    公开(公告)号：US20100158853A1

    公开(公告)日：2010-06-24

    申请号：US12536141

    申请日：2009-08-05

    申请人： Ryan DeSousa ,  Nissanke L. Dassanayake ,  Howard Allen Ketelson

    发明人： Ryan DeSousa ,  Nissanke L. Dassanayake ,  Howard Allen Ketelson

    IPC分类号： A01N33/12 ,  C08G73/00 ,  A01P1/00

    CPC分类号： A01N33/12 ,  A61K9/0048 ,  A61K9/08 ,  C08G73/0206 ,  C08G73/0213 ,  C08G73/0226 ,  C08G73/024 ,  C08L79/02

    摘要： Disclosed are polyquaternary ammonium polymers containing polyalkylene oxide groups according to formula (I) wherein [A]x, [B]y and [C]z are poly(alkylene oxides) each independently selected from the group consisting of poly(ethylene oxide), poly(propylene oxide), and poly(butylene oxide); Z is selected from the group consisting of —CH2CH═CHCH2—, —CH2CH2CH2CH2—, —CH2—C≡C—CH2—, —CH2CH2—O—CH2CH2—, —CH2—N(CH2CH2)2N—CH2—, —CH2CH(OH)CH(OH)CH2— and —CH2—C6H4—CH2—; R is —(CR1R2)mCR3R4— wherein m is an integer from 0 to 3 and R1, R2, R3 and R4 are independently selected from the group consisting of H, CH3 and CH2CH3; n is an integer from 1 to 30; x is either 0 or an integer from 2 to 20; y is an integer from 2 to 20; z is either 0 or an integer from 2 to 20; R′ is a branched or unbranched alkyl group having from 1 to 3 carbon atoms and is optionally substituted by one or two hydroxyl groups; Q1 and Q2 are independently selected from the group consisting of —CH2CH═CHCH2—X, —CH2C≡C—CH2—X, —N(R′)2, —N(R′)3, —N(R′)(R″), and —N(R′)2(R″), wherein X is a halogen atom and R″ is a benzyl group; and a stoichiometric amount of a pharmaceutically acceptable anion. Also disclosed are suitable methods of making the polymers, and methods of using the polymers.

    摘要翻译： 公开了含有根据式（I）的聚环氧烷基团的聚季铵盐聚合物，其中[A] x，[B] y和[C] z是聚（环氧烷），各自独立地选自聚环氧乙烷， 聚（环氧丙烷）和聚（环氧丁烷）; Z选自-CH 2 CH = CHCH 2 - ， - CH 2 CH 2 CH 2 CH 2 - ， - CH 2-C≡C-CH 2 - ， - CH 2 CH 2 -O-CH 2 CH 2 - ， - CH 2 -N（CH 2 CH 2）2 N-CH 2 - ， - CH 2 CH （OH）CH（OH）CH 2 - 和-CH 2 -C 6 H 4 -CH 2 - ; R是 - （CR 1 R 2）m CR 3 R 4 - ，其中m是0-3的整数，R 1，R 2，R 3和R 4独立地选自H，CH 3和CH 2 CH 3; n为1〜30的整数， x是0或2到20的整数; y为2〜20的整数; z为0或2至20的整数; R'是具有1至3个碳原子并且任选地被一个或两个羟基取代的支链或非支链烷基; Q1和Q2独立地选自-CH2CH = CHCH2-X，-CH2C≡C-CH2-X，-N（R'）2，-N（R'）3，-N（R'）（ R“）和-N（R'）2（R”），其中X是卤素原子，R“是苄基; 和化学计量的药学上可接受的阴离子。 还公开了制备聚合物的合适方法，以及使用聚合物的方法。