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1.发明申请Breaking immunological toterance with a genetically encoded unnatural amino acid 失效用遗传编码的非天然氨基酸破坏免疫学诱导公开(公告)号：US20090263376A1
公开(公告)日：2009-10-22
申请号：US12322938
申请日：2009-02-07
申请人： Jan Grunewald , Meng-Lin Tsao , Roshan Perera , Richard A. Lerner , Vaughn V. Smider , Peter G. Schultz
发明人： Jan Grunewald , Meng-Lin Tsao , Roshan Perera , Richard A. Lerner , Vaughn V. Smider , Peter G. Schultz
CPC分类号： C07K16/241 , A61K31/19 , A61K39/0008 , C07K16/44 , Y02A50/491 , Y02A50/492
摘要： The present invention comprises methods and compositions for producing and/or enhancing an immunological response in a subject against a target moiety such as a disease-related moiety by administration of an antigenic version of the target moiety having one or more unnatural amino acid and/or by administration of an antibody against a version of a target moiety having one or more unnatural amino acid which antibody is cross reactive with the natural target moiety.
摘要翻译： 本发明包括用于通过施用具有一个或多个非天然氨基酸的靶部分的抗原性版本来产生和/或增强受试者中针对靶部分例如疾病相关部分的免疫应答的方法和组合物，和/或 通过施用针对具有一个或多个非天然氨基酸的靶部分版本的抗体，该抗体与天然靶标部分交叉反应。
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2.发明授权Breaking immunological tolerance with a genetically encoded unnatural amino acid 失效用遗传编码的非天然氨基酸破坏免疫耐受公开(公告)号：US08318172B2
公开(公告)日：2012-11-27
申请号：US12322938
申请日：2009-02-07
申请人： Jan Grunewald , Meng-Lin Tsao , Roshan Perera , Richard A. Lerner , Vaughn V. Smider , Peter G. Schultz
发明人： Jan Grunewald , Meng-Lin Tsao , Roshan Perera , Richard A. Lerner , Vaughn V. Smider , Peter G. Schultz
IPC分类号： A61K39/00
CPC分类号： C07K16/241 , A61K31/19 , A61K39/0008 , C07K16/44 , Y02A50/491 , Y02A50/492
摘要： The present invention comprises methods and compositions for producing and/or enhancing an immunological response in a subject against a target moiety such as a disease-related moiety by administration of an antigenic version of the target moiety having one or more unnatural amino acid and/or by administration of an antibody against a version of a target moiety having one or more unnatural amino acid which antibody is cross reactive with the natural target moiety.
摘要翻译： 本发明包括用于通过施用具有一个或多个非天然氨基酸的靶部分的抗原性版本来产生和/或增强受试者中针对靶部分例如疾病相关部分的免疫应答的方法和组合物，和/或 通过施用针对具有一个或多个非天然氨基酸的靶部分版本的抗体，该抗体与天然靶标部分交叉反应。
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3.发明申请Breaking Immunological Tolerance with a Genetically Encoded Unnatural Amino Acid 审中-公开用遗传编码的非天然氨基酸破坏免疫耐受公开(公告)号：US20110052525A1
公开(公告)日：2011-03-03
申请号：US12735575
申请日：2009-02-07
申请人： Jan Grunewald , Meng-Lin Tsao , Roshan Perera , Richard A. Lerner , Vaughn V. Smider , Peter G. Schultz
发明人： Jan Grunewald , Meng-Lin Tsao , Roshan Perera , Richard A. Lerner , Vaughn V. Smider , Peter G. Schultz
IPC分类号： A61K38/19 , A61K39/395 , C12P21/02 , C07K14/525 , A61P37/04 , A61P35/00 , A61P31/04 , A61P31/12 , A61P31/10 , A61P33/02
CPC分类号： C07K16/241 , A61K31/19 , A61K39/0008 , C07K16/44
摘要： The present invention comprises methods and compositions for producing and/or enhancing an immunological response in a subject against a target moiety such as a disease-related moiety by administration of an antigenic version of the target moiety having one or more unnatural amino acid and/or by administration of an antibody against a version of a target moiety having one or more unnatural amino acid which antibody is cross reactive with the natural target moiety.
摘要翻译： 本发明包括用于通过施用具有一个或多个非天然氨基酸的靶部分的抗原性版本来产生和/或增强受试者中针对靶部分例如疾病相关部分的免疫应答的方法和组合物，和/或 通过施用针对具有一个或多个非天然氨基酸的靶部分版本的抗体，该抗体与天然靶标部分交叉反应。
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