Synthetic lipid mixtures for the preparation of a reconstituted surfactant
    2.
    发明授权
    Synthetic lipid mixtures for the preparation of a reconstituted surfactant 有权
    用于制备重构表面活性剂的合成脂质混合物

    公开(公告)号:US07511011B2

    公开(公告)日:2009-03-31

    申请号:US10512869

    申请日:2003-05-12

    IPC分类号: A61K38/16

    CPC分类号: C07K14/785 A61K38/00

    摘要: The invention relates to reconstituted surfactants consisting of artificial phospholipids and peptides able to lower the air-liquid surface tension, more particularly to reconstituted surfactants, comprising special phospholipid mixtures and artificial peptides which are analogues of the natural surfactant SP-C protein for the treatment of respiratory distress syndrome (RDS) and other diseases relates to pulmonary surfactant dysfunctions.

    摘要翻译: 本发明涉及由人造磷脂和能够降低空气 - 液体表面张力的肽组成的重构表面活性剂,更具体地说,涉及包含特殊磷脂混合物和人造肽的重构表面活性剂,其是天然表面活性剂SP-C蛋白的类似物,用于治疗 呼吸窘迫综合征(RDS)等疾病涉及肺表面活性物质功能障碍。

    Lipid mixtures for synthetic surfactants
    3.
    发明授权
    Lipid mixtures for synthetic surfactants 有权
    合成表面活性剂的脂质混合物

    公开(公告)号:US07811988B2

    公开(公告)日:2010-10-12

    申请号:US10558563

    申请日:2004-05-26

    IPC分类号: A61K31/23

    CPC分类号: A61K9/0073

    摘要: The present invention provides novel lipid mixtures for synthetic surfactants. In particular, the invention provides a specific lipid mixture containing a specific amount of polyunsaturated phospholipids to be used for the preparation of synthetic surfactants. Said surfactants and pharmaceutical compositions thereof are useful for the treatment of surfactant deficiencies like respiratory distress syndrome (RDS).

    摘要翻译: 本发明提供了用于合成表面活性剂的新型脂质混合物。 特别地,本发明提供了一种含有特定量的用于制备合成表面活性剂的多不饱和磷脂的脂质混合物。 所述表面活性剂及其药物组合物可用于治疗表面活性剂缺乏症如呼吸窘迫综合征(RDS)。

    Novel Lipid Mixtures For Synthetic Surfactants
    4.
    发明申请
    Novel Lipid Mixtures For Synthetic Surfactants 有权
    合成表面活性剂的新型脂质混合物

    公开(公告)号:US20080045449A1

    公开(公告)日:2008-02-21

    申请号:US10558563

    申请日:2004-05-26

    IPC分类号: A61K31/23 A61K38/16

    CPC分类号: A61K9/0073

    摘要: The present invention provides novel lipid mixtures for synthetic surfactants. In particular, the invention provides a specific lipid mixture containing a specific amount of polyunsaturated phospholipids to be used for the preparation of synthetic surfactants. Said surfactants and pharmaceutical compositions thereof are useful for the treatment of surfactant deficiencies like respiratory distress syndrome (RDS).

    摘要翻译: 本发明提供了用于合成表面活性剂的新型脂质混合物。 特别地,本发明提供了一种含有特定量的用于制备合成表面活性剂的多不饱和磷脂的脂质混合物。 所述表面活性剂及其药物组合物可用于治疗表面活性剂缺乏症如呼吸窘迫综合征(RDS)。

    SYNTHETIC LIPID MIXTURES FOR THE PREPARATION OF A RECONSTITUTED SURFACTANT
    7.
    发明申请
    SYNTHETIC LIPID MIXTURES FOR THE PREPARATION OF A RECONSTITUTED SURFACTANT 有权
    用于制备重复表面活性剂的合成脂质混合物

    公开(公告)号:US20080242589A1

    公开(公告)日:2008-10-02

    申请号:US12043177

    申请日:2008-03-06

    IPC分类号: A61K38/02 A61P11/00

    CPC分类号: C07K14/785 A61K38/00

    摘要: The invention relates to reconstituted surfactants consisting of artificial phospholipids and peptides able to lower the air-liquid surface tension, more particularly to reconstituted surfactants comprising special phospholipid mixtures and artificial peptides which are analogues of the natural surfactant SP-C protein for the treatment of respiratory distress syndrome (RDS) and other diseases relating to pulmonary surfactant dysfunctions.

    摘要翻译: 本发明涉及由能够降低空气 - 液体表面张力的人造磷脂和肽组成的重构表面活性剂,更具体地说涉及包含特殊磷脂混合物和人造肽的人造肽,其是天然表面活性剂SP-C蛋白的类似物,用于治疗呼吸 窘迫综合征(RDS)和其他与肺表面活性物质功能障碍有关的疾病。

    Reconstituted surfactants having improved properties
    8.
    发明授权
    Reconstituted surfactants having improved properties 有权
    具有改进性能的重新配制的表面活性剂

    公开(公告)号:US07897577B2

    公开(公告)日:2011-03-01

    申请号:US12131373

    申请日:2008-06-02

    IPC分类号: A61K38/00

    CPC分类号: C07K14/785 A61K38/00

    摘要: The present invention is directed to a reconstituted surfactant containing a lipid carrier, a polypeptide analog of the native surfactant protein SP-C, and a polypeptide comprising a sequence comprised of repeated units where each unit contains between 3 and 8 hydrophobic amino acid residues and one basic amino acid residue. The invention is also directed to the pharmaceutical compositions thereof and to its use for the prophylaxis and/or treatment of RDS and other respiratory disorders.

    摘要翻译: 本发明涉及含有脂质载体,天然表面活性蛋白SP-C的多肽类似物和包含重复单元的多肽的多肽的重构表面活性剂,其中每个单元含有3至8个疏水氨基酸残基和1个 碱性氨基酸残基。 本发明还涉及其药物组合物及其用于预防和/或治疗RDS和其它呼吸系统疾病的用途。

    RECONSTITUTED SURFACTANTS HAVING IMPROVED PROPERTIES
    9.
    发明申请
    RECONSTITUTED SURFACTANTS HAVING IMPROVED PROPERTIES 有权
    具有改进性质的重新配制的表面活性剂

    公开(公告)号:US20090088379A1

    公开(公告)日:2009-04-02

    申请号:US12131373

    申请日:2008-06-02

    IPC分类号: A61K38/16

    CPC分类号: C07K14/785 A61K38/00

    摘要: The present invention is directed to a reconstituted surfactant containing a lipid carrier, a polypeptide analog of the native surfactant protein SP-C, and a polypeptide comprising a sequence comprised of repeated units where each unit contains between 3 and 8 hydrophobic amino acid residues and one basic amino acid residue. The invention is also directed to the pharmaceutical compositions thereof and to its use for the prophylaxis and/or treatment of RDS and other respiratory disorders.

    摘要翻译: 本发明涉及含有脂质载体,天然表面活性蛋白SP-C的多肽类似物和包含重复单元的多肽的多肽的重构表面活性剂,其中每个单元含有3至8个疏水氨基酸残基和1个 碱性氨基酸残基。 本发明还涉及其药物组合物及其用于预防和/或治疗RDS和其它呼吸系统疾病的用途。

    Synthetic pulmonary surfactant peptides
    10.
    发明申请
    Synthetic pulmonary surfactant peptides 有权
    合成肺表面活性肽

    公开(公告)号:US20090075892A1

    公开(公告)日:2009-03-19

    申请号:US12222517

    申请日:2008-08-11

    IPC分类号: A61K38/00 C07K14/00 A61P11/00

    CPC分类号: C07K14/785 A61K38/00

    摘要: The present invention is directed to a reconstituted surfactant comprising a lipid carrier, a polypeptide analog of the native surfactant protein SP-C, and a polypeptide analog of the native surfactant protein SP-B. The invention is also directed to the pharmaceutical compositions thereof and to a use thereof in the treatment or prophylaxis of RDS and other respiratory disorders.

    摘要翻译: 本发明涉及包含脂质载体,天然表面活性蛋白SP-C的多肽类似物和天然表面活性蛋白SP-B的多肽类似物的重构表面活性剂。 本发明还涉及其药物组合物及其在治疗或预防RDS和其它呼吸系统疾病中的用途。