公开(公告)号：US20080286334A1

公开(公告)日：2008-11-20

申请号：US11932101

申请日：2007-10-31

申请人： JaneGuo Shiah ,  Rahul Bhagat ,  Wendy M. Blanda ,  Thierry Nivaggioli ,  Lin Peng ,  David Chou ,  David A. Weber

发明人： JaneGuo Shiah ,  Rahul Bhagat ,  Wendy M. Blanda ,  Thierry Nivaggioli ,  Lin Peng ,  David Chou ,  David A. Weber

IPC分类号： A61K31/573 ,  A61F2/14 ,  A61P27/02

CPC分类号： A61K31/573 ,  A61F9/0017 ,  A61K9/0051 ,  A61K9/1647 ,  A61K9/1694 ,  A61K9/204 ,  A61K31/56

摘要： The invention provides biodegradable implants sized for implantation in an ocular region and methods for treating medical conditions of the eye. The implants are formed from a mixture of hydrophilic end and hydrophobic end PLGA, and deliver active agents into an ocular region without a high burst release.

公开(公告)号：US20090163550A1

公开(公告)日：2009-06-25

申请号：US12388400

申请日：2009-02-18

申请人： Patrick M. HUGHES ,  Orest Olejnik ,  Glenn Tony Huang ,  Joan-En Chang-Lin ,  Thierry Nivaggioli ,  JaneGuo Shiah ,  Michele Boix ,  Christian Sarrazin

发明人： Patrick M. HUGHES ,  Orest Olejnik ,  Glenn Tony Huang ,  Joan-En Chang-Lin ,  Thierry Nivaggioli ,  JaneGuo Shiah ,  Michele Boix ,  Christian Sarrazin

IPC分类号： A61K31/4436 ,  A61P27/00

CPC分类号： A61K31/07 ,  A61K9/0051 ,  A61K9/1647 ,  A61K31/203

摘要： Biocompatible intraocular implants include a retinoid component and a biodegradable polymer that is effective to facilitate release of the retinoid component into an eye for an extended period of time. The therapeutic agents of the implants may be associated with a biodegradable polymer matrix, such as a matrix that is substantially free of a polyvinyl alcohol. The implants may be placed in an eye to treat or reduce the occurrence of one or more ocular conditions, such as retinal damage, including glaucoma and proliferative vitreoretinopathy.

摘要翻译： 生物相容性眼内植入物包括类视黄醇组分和可生物降解的聚合物，其有效促进类视黄醇组分长时间释放到眼睛中。 植入物的治疗剂可以与可生物降解的聚合物基质相关，例如基本上不含聚乙烯醇的基质。 植入物可以放置在眼睛中以治疗或减少一种或多种眼部病症的发生，例如视网膜损伤，包括青光眼和增生性玻璃体视网膜病变。

公开(公告)号：US20050271705A1

公开(公告)日：2005-12-08

申请号：US11119024

申请日：2005-04-29

申请人： Patrick Hughes ,  Orest Olejnik ,  Glenn Huang ,  Joan-En Chang-Lin ,  Thierry Nivaggioli ,  JaneGuo Shiah ,  Michele Boix ,  Christian Sarrazin

发明人： Patrick Hughes ,  Orest Olejnik ,  Glenn Huang ,  Joan-En Chang-Lin ,  Thierry Nivaggioli ,  JaneGuo Shiah ,  Michele Boix ,  Christian Sarrazin

IPC分类号： A61K9/00 ,  A61K9/16 ,  A61K31/07 ,  A61K31/203 ,  A61K31/19 ,  A61K31/20

CPC分类号： A61K31/07 ,  A61K9/0051 ,  A61K9/1647 ,  A61K31/203

摘要： Biocompatible intraocular implants include a retinoid component and a biodegradable polymer that is effective to facilitate release of the retinoid component into an eye for an extended period of time. The therapeutic agents of the implants may be associated with a biodegradable polymer matrix, such as a matrix that is substantially free of a polyvinyl alcohol. The implants may be placed in an eye to treat or reduce the occurrence of one or more ocular conditions, such as retinal damage, including glaucoma and proliferative vitreoretinopathy.

摘要翻译： 生物相容性眼内植入物包括类视黄醇组分和可生物降解的聚合物，其有效促进类视黄醇组分长时间释放到眼睛中。 植入物的治疗剂可以与可生物降解的聚合物基质相关，例如基本上不含聚乙烯醇的基质。 植入物可以放置在眼睛中以治疗或减少一种或多种眼部病症的发生，例如视网膜损伤，包括青光眼和增生性玻璃体视网膜病变。

公开(公告)号：US20110076318A1

公开(公告)日：2011-03-31

申请号：US12962427

申请日：2010-12-07

申请人： Patrick M. Hughes ,  Orest Olejnik ,  Glenn Tony Huang ,  Joan-En Chang-Lin ,  Thierry Nivaggioli ,  JaneGuo Shiah ,  Michele Boix ,  Christian Sarrazin

发明人： Patrick M. Hughes ,  Orest Olejnik ,  Glenn Tony Huang ,  Joan-En Chang-Lin ,  Thierry Nivaggioli ,  JaneGuo Shiah ,  Michele Boix ,  Christian Sarrazin

IPC分类号： A61M31/00 ,  A61K31/4436 ,  A61P27/02

CPC分类号： A61K31/07 ,  A61K9/0051 ,  A61K9/1647 ,  A61K31/203

摘要： Biocompatible intraocular implants include a retinoid component and a biodegradable polymer that is effective to facilitate release of the retinoid component into an eye for an extended period of time. The therapeutic agents of the implants may be associated with a biodegradable polymer matrix, such as a matrix that is substantially free of a polyvinyl alcohol. The implants may be placed in an eye to treat or reduce the occurrence of one or more ocular conditions, such as retinal damage, including glaucoma and proliferative vitreoretinopathy.

摘要翻译： 生物相容性眼内植入物包括类视黄醇组分和可生物降解的聚合物，其有效促进类视黄醇组分长时间释放到眼睛中。 植入物的治疗剂可以与可生物降解的聚合物基质相关，例如基本上不含聚乙烯醇的基质。 植入物可以放置在眼睛中以治疗或减少一种或多种眼部病症的发生，例如视网膜损伤，包括青光眼和增生性玻璃体视网膜病变。