公开(公告)号：US20050228246A1

公开(公告)日：2005-10-13

申请号：US11103963

申请日：2005-04-12

申请人： Jangwoen Lee ,  Bruce Tromberg ,  Albert Cerussi ,  Matthew Brenner

发明人： Jangwoen Lee ,  Bruce Tromberg ,  Albert Cerussi ,  Matthew Brenner

IPC分类号： A61B5/00 ,  G01J3/28 ,  G01N21/31 ,  G01N21/35 ,  G01N21/49

CPC分类号： A61B5/14551 ,  A61B5/14552 ,  A61B5/412 ,  G01N21/31 ,  G01N21/359 ,  G01N21/49 ,  G01N2201/08

摘要： A device and method utilizes a broadband diffuse optical spectroscopy (DOS) system to dynamically calculate the concentrations of multiple chromophores in vivo using a non-invasive probe. The device and method permit dynamic monitoring of multiple in vivo tissue chromophores non-invasively with sensitivities necessary for effective therapeutic monitoring. The device includes a probe containing first and second source optical fibers as well as first and second detector optical fibers. The probe is placed adjacent to a sample of interest and detects reflected light which is passed to a proximally located detector and spectrometer. The concentrations of multiple chromophores are determined in real time. In a preferred embodiment, the multiple tissue chromophores include at least two of methemoglobin (MetHb), deoxyhemoglobin (Hb-R), oxyhemoglobin (Hb-O2), water (H2O), and methylene blue (MB). The device and method can be used quantify and monitor methemoglobin formation in subjects suffering from methemoglobinemia.

摘要翻译： 一种使用宽带漫射光谱（DOS）系统的装置和方法使用非侵入性探针来动态地计算体内多个发色团的浓度。 该装置和方法允许非侵入性地动态监测多个体内组织发色团，具有有效治疗监测所需的灵敏度。 该装置包括包含第一和第二源光纤以及第一和第二检测器光纤的探针。 将探针放置在感兴趣的样本附近，并检测反射光，其被传递到位于近端的检测器和光谱仪。 多个发色团的浓度实时测定。 在优选实施方案中，多组织发色团包括高铁血红蛋白（MetHb），脱氧血红蛋白（Hb-R），氧合血红蛋白（Hb-O 2 H），水（H 2 O 2） SUB）和亚甲基蓝（MB）。 该装置和方法可用于定量和监测患有高铁血红蛋白血症的受试者中的高铁血红蛋白形成。

公开(公告)号：US07248909B2

公开(公告)日：2007-07-24

申请号：US11103963

申请日：2005-04-12

申请人： Jangwoen Lee ,  Bruce J. Tromberg ,  Albert E. Cerussi ,  Matthew Brenner

发明人： Jangwoen Lee ,  Bruce J. Tromberg ,  Albert E. Cerussi ,  Matthew Brenner

IPC分类号： A61B5/00

CPC分类号： A61B5/14551 ,  A61B5/14552 ,  A61B5/412 ,  G01N21/31 ,  G01N21/359 ,  G01N21/49 ,  G01N2201/08

摘要： A device and method utilizes a broadband diffuse optical spectroscopy (DOS) system to dynamically calculate the concentrations of multiple chromophores in vivo using a non-invasive probe. The device and method permit dynamic monitoring of multiple in vivo tissue chromophores non-invasively with sensitivities necessary for effective therapeutic monitoring. The device includes a probe containing first and second source optical fibers as well as first and second detector optical fibers. The probe is placed adjacent to a sample of interest and detects reflected light which is passed to a proximally located detector and spectrometer. The concentrations of multiple chromophores are determined in real time. In a preferred embodiment, the multiple tissue chromophores include at least two of methemoglobin (MetHb), deoxyhemoglobin (Hb-R), oxyhemoglobin (Hb-O2), water (H2O), and methylene blue (MB). The device and method can be used quantify and monitor methemoglobin formation in subjects suffering from methemoglobinemia.

摘要翻译： 一种使用宽带漫射光谱（DOS）系统的装置和方法使用非侵入性探针来动态地计算体内多个发色团的浓度。 该装置和方法允许非侵入性地动态监测多个体内组织发色团，具有有效治疗监测所需的灵敏度。 该装置包括包含第一和第二源光纤以及第一和第二检测器光纤的探针。 将探针放置在感兴趣的样本附近，并检测反射光，其被传递到位于近端的检测器和光谱仪。 多个发色团的浓度实时测定。 在优选实施方案中，多组织发色团包括高铁血红蛋白（MetHb），脱氧血红蛋白（Hb-R），氧合血红蛋白（Hb-O 2 H），水（H 2 O 2） SUB）和亚甲基蓝（MB）。 该装置和方法可用于定量和监测患有高铁血红蛋白血症的受试者中的高铁血红蛋白形成。