公开(公告)号：US20210196831A1

公开(公告)日：2021-07-01

申请号：US17142192

申请日：2021-01-05

Applicant: Janssen BioPharma, Inc.

Inventor： Sergei GRYAZNOV ,  Leonid BEIGELMAN ,  Theodore YUN

IPC: A61K47/54 ,  A61P31/20 ,  A61P35/00 ,  A61K39/39 ,  A61K47/22 ,  A61K47/26 ,  C12Q1/6876 ,  A61K47/14 ,  A61K9/00 ,  A61K31/7088

Abstract: Oligodeoxynucleotide-based immunostimulatory Toll-Like Receptor 9 (TLR9) agonists are described. Also described are compositions comprising the TLR9 agonists, methods of making the TLR9 agonists, and methods of using the TLR9 agonists to treat immune diseases, disorders or conditions, such as viral infections or cancer.