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公开(公告)号：US20230365608A1
公开(公告)日：2023-11-16
申请号：US17426974
申请日：2020-01-30
发明人： Leonid BEIGELMAN , Guangyi WANG , Natalia DYATKINA
摘要： Disclosed herein are nucleoside compounds and derivatives thereof, pharmaceutical compositions containing same, and their methods of synthesis. The compounds are useful in treating orthomyxovirus infections, such as influenza infections.
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公开(公告)号：US20220363640A1
公开(公告)日：2022-11-17
申请号：US17208964
申请日：2021-03-22
发明人： Guangyi WANG , Leonid BEIGELMAN , Anh TRUONG , Carmela NAPOLITANO , Daniele ANDREOTTI , Haiying HE , Karin Ann STEIN
IPC分类号： C07D213/40 , C07D409/04 , C07D495/14 , C07D401/04 , C07D413/04 , C07D417/04 , C07D239/34 , C07D471/04 , C07D213/65 , C07D401/12 , C07D491/048 , C07D233/64 , C07D409/14 , C07D417/06 , C07D413/12 , C07D413/06 , C07D401/06 , C07D405/12 , C07D417/12 , C07D207/273 , C07D491/052 , A61K31/4436 , A61K31/4418 , A61K31/4178 , A61K31/4439 , A61K31/4365 , A61K31/422 , A61K31/4196 , A61K31/427 , A61K31/505 , A61K31/437 , A61K45/06 , A61K31/4355 , A61K31/444 , A61K31/4709
摘要： Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection with one or more small molecule compounds. Examples of paramyxovirus infection include an infection caused by human respiratory syncytial virus (RSV).
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公开(公告)号：US20210196831A1
公开(公告)日：2021-07-01
申请号：US17142192
申请日：2021-01-05
发明人： Sergei GRYAZNOV , Leonid BEIGELMAN , Theodore YUN
IPC分类号： A61K47/54 , A61P31/20 , A61P35/00 , A61K39/39 , A61K47/22 , A61K47/26 , C12Q1/6876 , A61K47/14 , A61K9/00 , A61K31/7088
摘要： Oligodeoxynucleotide-based immunostimulatory Toll-Like Receptor 9 (TLR9) agonists are described. Also described are compositions comprising the TLR9 agonists, methods of making the TLR9 agonists, and methods of using the TLR9 agonists to treat immune diseases, disorders or conditions, such as viral infections or cancer.
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公开(公告)号：US20190381081A1
公开(公告)日：2019-12-19
申请号：US16449164
申请日：2019-06-21
IPC分类号： A61K31/708 , C07H19/20 , C07H19/06 , C07H19/16 , C07H19/10 , C07H19/12 , C07H19/207 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/706
摘要： Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a nucleoside, a nucleotide and an analog thereof.
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公开(公告)号：US20220396581A1
公开(公告)日：2022-12-15
申请号：US17228573
申请日：2021-04-12
发明人： Guangyi WANG , Leonid BEIGELMAN , Anh TRUONG , Carmela NAPOLITANO , Daniele ANDREOTTI , Haiying HE
IPC分类号： C07D495/04 , A61K31/352 , A61K31/4196 , A61K31/4365 , C07C255/66 , C07D233/88 , C07D261/20 , C07D307/40 , C07D307/52 , C07D333/20 , C07D333/58 , A61K31/4025 , A61K31/404 , A61K31/427 , A61K31/4375 , A61K31/4725 , C07D213/50 , C07D233/64 , C07D333/68 , C07D401/12 , C07D409/06 , A61K31/343 , A61K31/382 , A61K31/426 , A61K31/4418 , A61K31/4545 , C07C251/84 , C07D207/335 , C07D215/12 , C07D215/42 , C07D233/61 , C07D401/04 , C07D409/14 , A61K31/277 , A61K31/407 , A61K31/423 , A61K31/4436 , A61K31/4439 , A61K31/496 , A61K31/497 , A61K31/506 , C07C243/34 , C07D209/20 , C07D209/86 , C07D233/38 , C07D233/60 , C07D277/64 , C07D307/81 , C07D405/10 , C07D417/04 , C07D417/12 , A61K31/165 , A61K31/40 , A61K31/4709 , C07C243/18 , C07D277/56 , C07D333/66 , C07D413/04 , C07D471/04 , C07D495/14 , A61K31/4427 , A61K31/5377 , C07D213/42 , C07D213/68 , C07D215/38 , C07D217/24 , C07D307/91 , C07D311/68 , C07D333/16 , C07D333/62 , C07D401/10 , C07D409/12 , A61K31/341 , A61K31/4164 , A61K31/428 , A61K31/444 , A61K31/4704 , A61K31/501 , A61K45/06 , C07C255/34 , C07D209/08 , C07D215/14 , C07D333/54 , C07D335/06 , C07D405/04 , C07D405/12 , C07D409/04 , C07D413/12 , C07D413/14 , A61K31/381 , A61K31/4155 , A61K31/47 , A61K31/538 , C07C251/80 , C07D209/14 , C07D213/65 , C07D333/50 , C07D333/76
摘要： Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection with one or more small molecule compounds. Examples of paramyxovirus infection include an infection caused by human respiratory syncytial virus (RSV).
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公开(公告)号：US20210179656A1
公开(公告)日：2021-06-17
申请号：US17178151
申请日：2021-02-17
IPC分类号： C07H19/06 , C07H19/207 , C07H19/16 , A61P31/16 , A61K45/06 , C07D405/04 , C07D405/14 , C07D473/18 , C07D473/34 , C07D487/04 , C07D493/04 , C07H19/00 , C07H19/14 , C12N9/12 , C07H19/10 , C07H19/12 , C07H19/20
摘要： Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a nucleoside, a nucleotide and an analog thereof.
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公开(公告)号：US20200277321A1
公开(公告)日：2020-09-03
申请号：US16648405
申请日：2018-09-18
发明人： Leonid BEIGELMAN , Jerome DEVAL , Marija PRHAVC
摘要： Disclosed herein are compounds of the Formula (I) and pharmaceutically acceptable salts thereof: (I) where the variables in Formula (I) are described herein. Methods of synthesizing such compounds and methods of using them to treat diseases and/or conditions such as a Picornaviridae, Flaviviridae, Filoviridae, Pneumoviridae and/or Coronaviridae viral infections are also disclosed.
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公开(公告)号：US20200024297A1
公开(公告)日：2020-01-23
申请号：US16528414
申请日：2019-07-31
IPC分类号： C07H19/06 , C07H19/20 , C07H19/12 , C07H19/10 , C07H19/16 , C07H19/207 , C12N9/12 , C07H19/14 , C07H19/00 , C07D493/04 , C07D487/04 , C07D473/34 , C07D473/18 , C07D405/14 , C07D405/04 , A61K45/06 , A61P31/16
摘要： Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a nucleoside, a nucleotide and an analog thereof.
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公开(公告)号：US20240309040A1
公开(公告)日：2024-09-19
申请号：US18672651
申请日：2024-05-23
摘要： The present disclosure relates to compounds and compositions containing 5′-phosphoramidite nucleoside monomers, and methods of making and use.
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公开(公告)号：US20210186969A1
公开(公告)日：2021-06-24
申请号：US17185750
申请日：2021-02-25
IPC分类号： A61K31/5025 , C07D487/04 , A61K31/13 , A61K31/196 , A61K31/215 , A61K31/351 , A61K31/4965 , A61K31/5377 , A61K31/7056 , A61K38/21 , C07B59/00
摘要： Disclosed herein are aza-pyridone compounds, pharmaceutical compositions that include one or more aza-pyridone compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an orthomyxovirus infection, with an aza-pyridone compounds. Examples of an orthomyxovirus viral infection include an influenza infection.
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