公开(公告)号：US20230365608A1

公开(公告)日：2023-11-16

申请号：US17426974

申请日：2020-01-30

Applicant: Janssen BioPharma, Inc.

Inventor： Leonid BEIGELMAN ,  Guangyi WANG ,  Natalia DYATKINA

IPC: C07H7/06 ,  C07H15/04 ,  A61P31/16

CPC classification number: C07H7/06 ,  C07H15/04 ,  A61P31/16

Abstract: Disclosed herein are nucleoside compounds and derivatives thereof, pharmaceutical compositions containing same, and their methods of synthesis. The compounds are useful in treating orthomyxovirus infections, such as influenza infections.

公开(公告)号：US20220363640A1

公开(公告)日：2022-11-17

申请号：US17208964

申请日：2021-03-22

Applicant: Janssen BioPharma, Inc.

Inventor： Guangyi WANG ,  Leonid BEIGELMAN ,  Anh TRUONG ,  Carmela NAPOLITANO ,  Daniele ANDREOTTI ,  Haiying HE ,  Karin Ann STEIN

IPC: C07D213/40 ,  C07D409/04 ,  C07D495/14 ,  C07D401/04 ,  C07D413/04 ,  C07D417/04 ,  C07D239/34 ,  C07D471/04 ,  C07D213/65 ,  C07D401/12 ,  C07D491/048 ,  C07D233/64 ,  C07D409/14 ,  C07D417/06 ,  C07D413/12 ,  C07D413/06 ,  C07D401/06 ,  C07D405/12 ,  C07D417/12 ,  C07D207/273 ,  C07D491/052 ,  A61K31/4436 ,  A61K31/4418 ,  A61K31/4178 ,  A61K31/4439 ,  A61K31/4365 ,  A61K31/422 ,  A61K31/4196 ,  A61K31/427 ,  A61K31/505 ,  A61K31/437 ,  A61K45/06 ,  A61K31/4355 ,  A61K31/444 ,  A61K31/4709

Abstract: Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection with one or more small molecule compounds. Examples of paramyxovirus infection include an infection caused by human respiratory syncytial virus (RSV).

公开(公告)号：US20210196831A1

公开(公告)日：2021-07-01

申请号：US17142192

申请日：2021-01-05

Applicant: Janssen BioPharma, Inc.

Inventor： Sergei GRYAZNOV ,  Leonid BEIGELMAN ,  Theodore YUN

IPC: A61K47/54 ,  A61P31/20 ,  A61P35/00 ,  A61K39/39 ,  A61K47/22 ,  A61K47/26 ,  C12Q1/6876 ,  A61K47/14 ,  A61K9/00 ,  A61K31/7088

Abstract: Oligodeoxynucleotide-based immunostimulatory Toll-Like Receptor 9 (TLR9) agonists are described. Also described are compositions comprising the TLR9 agonists, methods of making the TLR9 agonists, and methods of using the TLR9 agonists to treat immune diseases, disorders or conditions, such as viral infections or cancer.

公开(公告)号：US20190381081A1

公开(公告)日：2019-12-19

申请号：US16449164

申请日：2019-06-21

Applicant: Janssen BioPharma, Inc.

Inventor： Guangyi WANG ,  David Bernard SMITH ,  Leonid BEIGELMAN ,  Jerome DEVAL ,  Marija PRHAVC

IPC: A61K31/708 ,  C07H19/20 ,  C07H19/06 ,  C07H19/16 ,  C07H19/10 ,  C07H19/12 ,  C07H19/207 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/7076 ,  A61K31/706

Abstract: Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a nucleoside, a nucleotide and an analog thereof.

公开(公告)号：US20220396581A1

公开(公告)日：2022-12-15

申请号：US17228573

申请日：2021-04-12

Applicant: Janssen BioPharma, Inc.

Inventor： Guangyi WANG ,  Leonid BEIGELMAN ,  Anh TRUONG ,  Carmela NAPOLITANO ,  Daniele ANDREOTTI ,  Haiying HE

IPC: C07D495/04 ,  A61K31/352 ,  A61K31/4196 ,  A61K31/4365 ,  C07C255/66 ,  C07D233/88 ,  C07D261/20 ,  C07D307/40 ,  C07D307/52 ,  C07D333/20 ,  C07D333/58 ,  A61K31/4025 ,  A61K31/404 ,  A61K31/427 ,  A61K31/4375 ,  A61K31/4725 ,  C07D213/50 ,  C07D233/64 ,  C07D333/68 ,  C07D401/12 ,  C07D409/06 ,  A61K31/343 ,  A61K31/382 ,  A61K31/426 ,  A61K31/4418 ,  A61K31/4545 ,  C07C251/84 ,  C07D207/335 ,  C07D215/12 ,  C07D215/42 ,  C07D233/61 ,  C07D401/04 ,  C07D409/14 ,  A61K31/277 ,  A61K31/407 ,  A61K31/423 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  C07C243/34 ,  C07D209/20 ,  C07D209/86 ,  C07D233/38 ,  C07D233/60 ,  C07D277/64 ,  C07D307/81 ,  C07D405/10 ,  C07D417/04 ,  C07D417/12 ,  A61K31/165 ,  A61K31/40 ,  A61K31/4709 ,  C07C243/18 ,  C07D277/56 ,  C07D333/66 ,  C07D413/04 ,  C07D471/04 ,  C07D495/14 ,  A61K31/4427 ,  A61K31/5377 ,  C07D213/42 ,  C07D213/68 ,  C07D215/38 ,  C07D217/24 ,  C07D307/91 ,  C07D311/68 ,  C07D333/16 ,  C07D333/62 ,  C07D401/10 ,  C07D409/12 ,  A61K31/341 ,  A61K31/4164 ,  A61K31/428 ,  A61K31/444 ,  A61K31/4704 ,  A61K31/501 ,  A61K45/06 ,  C07C255/34 ,  C07D209/08 ,  C07D215/14 ,  C07D333/54 ,  C07D335/06 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04 ,  C07D413/12 ,  C07D413/14 ,  A61K31/381 ,  A61K31/4155 ,  A61K31/47 ,  A61K31/538 ,  C07C251/80 ,  C07D209/14 ,  C07D213/65 ,  C07D333/50 ,  C07D333/76

Abstract: Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection with one or more small molecule compounds. Examples of paramyxovirus infection include an infection caused by human respiratory syncytial virus (RSV).

公开(公告)号：US20210179656A1

公开(公告)日：2021-06-17

申请号：US17178151

申请日：2021-02-17

Applicant: Janssen BioPharma, Inc.

Inventor： Leonid BEIGELMAN ,  Guangyi WANG ,  David Bernard SMITH ,  Jerome DEVAL ,  Marija PRHAVC

IPC: C07H19/06 ,  C07H19/207 ,  C07H19/16 ,  A61P31/16 ,  A61K45/06 ,  C07D405/04 ,  C07D405/14 ,  C07D473/18 ,  C07D473/34 ,  C07D487/04 ,  C07D493/04 ,  C07H19/00 ,  C07H19/14 ,  C12N9/12 ,  C07H19/10 ,  C07H19/12 ,  C07H19/20

Abstract: Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a nucleoside, a nucleotide and an analog thereof.

公开(公告)号：US20200277321A1

公开(公告)日：2020-09-03

申请号：US16648405

申请日：2018-09-18

Applicant: JANSSEN BIOPHARMA, INC.

Inventor： Leonid BEIGELMAN ,  Jerome DEVAL ,  Marija PRHAVC

IPC: C07H7/06 ,  A61P31/14 ,  C07H9/04 ,  A61P31/16

Abstract: Disclosed herein are compounds of the Formula (I) and pharmaceutically acceptable salts thereof: (I) where the variables in Formula (I) are described herein. Methods of synthesizing such compounds and methods of using them to treat diseases and/or conditions such as a Picornaviridae, Flaviviridae, Filoviridae, Pneumoviridae and/or Coronaviridae viral infections are also disclosed.

公开(公告)号：US20200024297A1

公开(公告)日：2020-01-23

申请号：US16528414

申请日：2019-07-31

Applicant: Janssen BioPharma, Inc.

Inventor： Leonid BEIGELMAN ,  Guangyi WANG ,  David Bernard SMITH ,  Jerome DEVAL ,  Marija PRHAVC

IPC: C07H19/06 ,  C07H19/20 ,  C07H19/12 ,  C07H19/10 ,  C07H19/16 ,  C07H19/207 ,  C12N9/12 ,  C07H19/14 ,  C07H19/00 ,  C07D493/04 ,  C07D487/04 ,  C07D473/34 ,  C07D473/18 ,  C07D405/14 ,  C07D405/04 ,  A61K45/06 ,  A61P31/16

Abstract: Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a nucleoside, a nucleotide and an analog thereof.

公开(公告)号：US20240309040A1

公开(公告)日：2024-09-19

申请号：US18672651

申请日：2024-05-23

Applicant: Janssen BioPharma, Inc.

Inventor： Sergei GRYAZNOV ,  Jin HONG ,  Vivek Kumar RAJWANSHI ,  Leonid BEIGELMAN

IPC: C07H19/10 ,  C07H1/00 ,  C07H19/20

CPC classification number: C07H19/10 ,  C07H1/00 ,  C07H19/20

Abstract: The present disclosure relates to compounds and compositions containing 5′-phosphoramidite nucleoside monomers, and methods of making and use.

公开(公告)号：US20210186969A1

公开(公告)日：2021-06-24

申请号：US17185750

申请日：2021-02-25

Applicant: Janssen BioPharma, Inc.

Inventor： Robert Than HENDRICKS ,  Leonid BEIGELMAN ,  David Bernard SMITH ,  Antitsa Dimitrova STOYCHEVA

IPC: A61K31/5025 ,  C07D487/04 ,  A61K31/13 ,  A61K31/196 ,  A61K31/215 ,  A61K31/351 ,  A61K31/4965 ,  A61K31/5377 ,  A61K31/7056 ,  A61K38/21 ,  C07B59/00

Abstract: Disclosed herein are aza-pyridone compounds, pharmaceutical compositions that include one or more aza-pyridone compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an orthomyxovirus infection, with an aza-pyridone compounds. Examples of an orthomyxovirus viral infection include an influenza infection.