公开(公告)号：US20190062420A1

公开(公告)日：2019-02-28

申请号：US16111360

申请日：2018-08-24

Applicant: Janssen Biotech, Inc.

Inventor： Mark Chiu ,  Brian Whitaker ,  Di Zhang

IPC: C07K16/24 ,  A61P35/00 ,  C07K16/28

Abstract: FN3 domains that specifically bind FcγRII, their conjugates and antibody fusions, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making and using them.

公开(公告)号：US11359029B2

公开(公告)日：2022-06-14

申请号：US16840830

申请日：2020-04-06

Applicant: Janssen Biotech, Inc.

Inventor： Mark Chiu ,  Di Zhang

IPC: C07K16/28

Abstract: The present invention relates to engineered anti-TNFR superfamily member antibodies having enhanced agonistic activity and methods of using them.

公开(公告)号：US20200231693A1

公开(公告)日：2020-07-23

申请号：US16840830

申请日：2020-04-06

Applicant: Janssen Biotech, Inc.

Inventor： Mark Chiu ,  Di Zhang

IPC: C07K16/28

Abstract: The present invention relates to engineered anti-TNFR superfamily member antibodies having enhanced agonistic activity and methods of using them.

公开(公告)号：US10669344B2

公开(公告)日：2020-06-02

申请号：US15662866

申请日：2017-07-28

Applicant: Janssen Biotech, Inc.

Inventor： Anthony Armstrong ,  Mark Chiu ,  Di Zhang

IPC: C07K16/28 ,  C07K16/30 ,  A61K39/00

Abstract: The present invention relates to engineered antibodies and other Fc-domain containing molecules with enhanced agonism and effector functions.

公开(公告)号：US20180044427A1

公开(公告)日：2018-02-15

申请号：US15662866

申请日：2017-07-28

Applicant: Janssen Biotech, Inc.

Inventor： Anthony Armstrong ,  Mark Chiu ,  Di Zhang

IPC: C07K16/28 ,  C07K16/30

Abstract: The present invention relates to engineered antibodies and other Fc-domain containing molecules with enhanced agonism and effector functions.

公开(公告)号：US11078263B2

公开(公告)日：2021-08-03

申请号：US16111360

申请日：2018-08-24

Applicant: Janssen Biotech, Inc.

Inventor： Mark Chiu ,  Brian Whitaker ,  Di Zhang

IPC: C07K14/435 ,  C07K14/47 ,  C07K14/78 ,  C07K16/18 ,  C07K19/00 ,  A61K38/17 ,  A61K38/39 ,  A61K39/395 ,  C07K16/24 ,  A61P35/00 ,  C07K16/28 ,  C12N15/70

Abstract: FN3 domains that specifically bind FcγRII, their conjugates and antibody fusions, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making and using them.

公开(公告)号：US20180044430A1

公开(公告)日：2018-02-15

申请号：US15668895

申请日：2017-08-04

Applicant: Janssen Biotech, Inc.

Inventor： Mark Chiu ,  Di Zhang

IPC: C07K16/28

CPC classification number: C07K16/2878 ,  C07K2317/52 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/75

Abstract: The present invention relates to engineered anti-TNFR superfamily member antibodies having enhanced agonistic activity and methods of using them.