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    COMPOSITIONS AND METHODS FOR PHAGOCYTE DELIVERY OF ANTI-STAPHYLOCOCCAL AGENTS
    2.
    发明申请
    COMPOSITIONS AND METHODS FOR PHAGOCYTE DELIVERY OF ANTI-STAPHYLOCOCCAL AGENTS 有权
    抗血小板药物的药物递送的组合物和方法

    公开(公告)号：US20150210756A1

    公开(公告)日：2015-07-30

    申请号：US14565069

    申请日：2014-12-09

    Applicant: New York University ,  Janssen Biotech, Inc.

    Inventor： Victor J. Torres ,  Randall J. Brezski ,  Anthony Lynch ,  William Strohl ,  Brian Whitaker ,  Mark Chiu ,  Peter T. Buckley ,  Keri Dorn ,  Michelle Kinder

    IPC: C07K16/12 ,  G01N33/569

    CPC classification number: C07K16/1271 ,  C07K14/78 ,  C07K2317/30 ,  C07K2317/31 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2318/00 ,  C07K2319/70 ,  G01N33/56938 ,  G01N2469/10

    Abstract: The present application generally relates to multi-specific molecules that bind to multiple bacterial virulence factors, methods for producing these binding molecules, and the use of these binding molecules to treat bacterial infections. In particular, the binding molecules comprise at least two binding domains, preferably an antibody or antibody fragment and an alternative scaffold. The first binding domain is capable of binding to a glycosylated staphylococcal surface protein, preferably an SDR-containing protein. The second binding domain is capable of binding to a staphylococcal leukotoxin, preferably LukAB, LukD or LukE. These multi-specific binding compounds have killing activity against staphylococci and, thus, can be used in the treatment and/or amelioration of a Staphylococcus infection, including methicillin-resistant Staphylococcus aureus.

    Abstract translation: 本申请通常涉及结合多种细菌毒力因子的多特异性分子，用于产生这些结合分子的方法，以及这些结合分子用于治疗细菌感染的用途。 特别地，结合分子包含至少两个结合结构域，优选抗体或抗体片段和替代性支架。 第一结合结构域能够结合糖基化的葡萄球菌表面蛋白，优选含有SDR的蛋白质。 第二结合结构域能够结合葡萄球菌白血病，优选LukAB，LukD或LukE。 这些多特异性结合化合物对葡萄球菌具有杀伤活性，因此可用于治疗和/或改善葡萄球菌感染，包括耐甲氧西林金黄色葡萄球菌。

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