公开(公告)号：US20250019428A1

公开(公告)日：2025-01-16

申请号：US18765711

申请日：2024-07-08

Applicant: Janssen Biotech, Inc.

Inventor： Kristopher Barnthouse ,  Subinay Ganguly ,  Maarten Groeneveld ,  Manuel Lopez, JR. ,  Michael Nedved ,  Kevin D. Smith

IPC: C07K16/24 ,  A61K39/00 ,  A61K39/395

Abstract: The present invention relates to methods of manufacture for producing anti-TNF antibodies, e.g., the anti-TNF antibody a recombinant anti-TNF antibody having a heavy chain (HC) comprising amino acid sequence SEQ ID NO:36 and a light chain (LC) comprising amino acid sequence SEQ ID NO:37 and compositions comprising the recombinant anti-TNF antibody.

公开(公告)号：US20250019429A1

公开(公告)日：2025-01-16

申请号：US18892683

申请日：2024-09-23

Applicant: Janssen Biotech, Inc.

Inventor： Kristopher Barnthouse ,  Subinay Ganguly ,  Maarten Groeneveld ,  Manuel Lopez, JR. ,  Michael Nedved ,  Kevin D. Smith

IPC: C07K16/24

Abstract: Presented here are methods for producing a recombinant anti-TNF antibody having a heavy chain (HC) comprising SEQ ID NO:38 and a light chain (LC) comprising SEQ ID NO:37 and compositions comprising the recombinant anti-TNF antibody.

公开(公告)号：US20230040065A1

公开(公告)日：2023-02-09

申请号：US17860244

申请日：2022-07-08

Applicant: Janssen Biotech, Inc.

Inventor： Kristopher Barnthouse ,  John Brown ,  Brett Hanna ,  Linda Hendricks ,  Manuel Lopez, JR. ,  Mark Panek ,  Denis Twomey ,  David Volkin

IPC: C07K16/24

Abstract: The present invention relates to methods of manufacture for producing a drug substance (DS) or drug product (DP) comprising a mammalian anti-TNF antibody having a heavy chain (HC) comprising SEQ ID NO: 36 and a light chain (LC) comprising SEQ ID NO: 37.

公开(公告)号：US20250066465A1

公开(公告)日：2025-02-27

申请号：US18882902

申请日：2024-09-12

Applicant: Janssen Biotech, Inc.

Inventor： Kristopher Barnthouse ,  Subinay Ganguly ,  Maarten Groeneveld ,  Manuel Lopez, JR. ,  Michael Nedved ,  Kevin D. Smith

IPC: C07K16/24

Abstract: Presented here are methods for producing a recombinant anti-TNF antibody having a heavy chain (HC) comprising SEQ ID NO:38 and a light chain (LC) comprising SEQ ID NO:37 and compositions comprising the recombinant anti-TNF antibody.

公开(公告)号：US20240383976A1

公开(公告)日：2024-11-21

申请号：US18427000

申请日：2024-01-30

Applicant: Janssen Biotech, Inc.

Inventor： Kristopher Barnthouse ,  Subinay Ganguly ,  Maarten Groeneveld ,  Manuel Lopez, JR. ,  Michael Nedved ,  Kevin D. Smith

IPC: C07K16/24 ,  C07K1/18 ,  C12N5/071

Abstract: Methods of manufacture for producing anti-IL-12/IL-23p40 antibodies, e.g., the anti-IL-12/IL-23p40 antibody ustekinumab, in CHO and specific pharmaceutical compositions of the antibody are useful in treating various diseases.