公开(公告)号：US09206244B2

公开(公告)日：2015-12-08

申请号：US14225821

申请日：2014-03-26

Applicant: Janssen Biotech, Inc.

Inventor： Michael Baumann ,  Gaby Tresch ,  Steven Jacobs ,  Karyn O'Neil

IPC: C07K14/705 ,  C07K14/47 ,  A61K38/00

CPC classification number: C07K14/705 ,  A61K38/00 ,  C07K14/47 ,  C07K2319/70 ,  Y02A50/409 ,  Y02A50/423

Abstract: IL4/IL13-binding proteins comprise binding domains, which inhibit IL4/IL13 binding to IL4Ralpha and common gamma chain complexes (Type 1) and inhibit IL4 binding to IL4Ralpha and IL13Ralpha1 complexes (Type 2), and IL13 binding to IL13Ralpha1 and/or IL13Ralpha2, are useful in the treatment of cancer, inflammatory, and other pathological conditions, such as allergic or fibrotic conditions, especially pulmonary conditions.

Abstract translation: IL4 / IL13结合蛋白包含结合结构域，其抑制IL4 / IL13与IL4Rα和常见的γ链复合物（1型）结合并抑制IL4与IL4Rα和IL13Rα1复合物（2型）的结合，IL13与IL13Rα1和/或IL13Rα2的结合 ，可用于治疗癌症，炎症和其他病理状况，如过敏或纤维化病症，特别是肺部疾病。

公开(公告)号：US20140206599A1

公开(公告)日：2014-07-24

申请号：US14225821

申请日：2014-03-26

Applicant: Janssen Biotech, Inc.

Inventor： Michael Baumann ,  Gaby Tresch ,  Steven Jacobs ,  Karyn O'Neil

IPC: C07K14/705

CPC classification number: C07K14/705 ,  A61K38/00 ,  C07K14/47 ,  C07K2319/70 ,  Y02A50/409 ,  Y02A50/423

Abstract: IL4/IL13-binding proteins comprise binding domains, which inhibit IL4/IL13 binding to IL4Ralpha and common gamma chain complexes (Type 1) and inhibit IL4 binding to IL4Ralpha and IL13Ralpha1 complexes (Type 2), and IL13 binding to IL13Ralpha1 and/or IL13Ralpha2, are useful in the treatment of cancer, inflammatory, and other pathological conditions, such as allergic or fibrotic conditions, especially pulmonary conditions.

Abstract translation: IL4 / IL13结合蛋白包含结合结构域，其抑制IL4 / IL13与IL4Rα和常见的γ链复合物（1型）结合并抑制IL4与IL4Rα和IL13Rα1复合物（2型）的结合，IL13与IL13Rα1和/或IL13Rα2的结合 ，可用于治疗癌症，炎症和其他病理状况，如过敏或纤维化病症，特别是肺部疾病。