公开(公告)号：US20230037448A1

公开(公告)日：2023-02-09

申请号：US17773098

申请日：2020-10-30

Applicant: Janssen Biotech, Inc.

Inventor： Justin Cisar ,  Colleen Keohane ,  Scott Kuduk

IPC: C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  A61P35/00 ,  A61P35/02

Abstract: Disclosed are compounds, compositions and methods for treating diseases, disorders, or medical conditions that are affected by the modulation of DHODH. Such compounds are represented by Formula (I) as follows: wherein R1a, R1b, R2, and R3, are defined herein.

公开(公告)号：US11981658B2

公开(公告)日：2024-05-14

申请号：US17822450

申请日：2022-08-26

Applicant: YUHAN CORPORATION ,  JANSSEN BIOTECH, INC.

Inventor： Byoungmoon Lee ,  Hyunjoo Lee ,  Gyu Jin Lee ,  Su Bin Choi ,  Sol Park ,  Heejun Kim ,  Misong Kim ,  Young Ae Yoon ,  Kwan Hoon Hyun ,  Tae Kyun Kim ,  Jae Young Sim ,  Marian C. Bryan ,  Scott Kuduk ,  James Campbell Robertson

IPC: C07D401/14

CPC classification number: C07D401/14

Abstract: Provided are aminopyridine compounds and pharmaceutically acceptable compositions thereof which exhibit inhibition activity against certain mutated forms of EGFR.

公开(公告)号：US11945798B2

公开(公告)日：2024-04-02

申请号：US17822438

申请日：2022-08-26

Applicant: YUHAN CORPORATION ,  JANSSEN BIOTECH, INC.

Inventor： Hyunjoo Lee ,  Su Bin Choi ,  Young Ae Yoon ,  Kwan Hoon Hyun ,  Jae Young Sim ,  Marian C. Bryan ,  Scott Kuduk ,  James Campbell Robertson ,  Jaekyoo Lee ,  Paresh Devidas Salgaonkar ,  Byung-Chul Suh ,  Jong Sung Koh ,  So Young Hwang

IPC: C07D401/14 ,  C07D413/14

CPC classification number: C07D401/14 ,  C07D413/14

Abstract: Provided are aminopyridine compounds and pharmaceutically acceptable compositions thereof which exhibit inhibition activity against certain mutated forms of EGFR.

公开(公告)号：US20220298107A1

公开(公告)日：2022-09-22

申请号：US17638220

申请日：2020-08-27

Applicant: Janssen Biotech, Inc.

Inventor： Scott Kuduk ,  Lindsey DeRatt

IPC: C07D205/04 ,  C07C275/40 ,  C07D213/75 ,  C07D207/16 ,  C07D207/12 ,  C07D401/12 ,  C07D403/12

Abstract: Disclosed are compounds, compositions and methods for treating diseases, disorders, or medical conditions that are affected by the modulation of DHODH. Such compounds are represented by Formula I as follows: wherein R1, R2, R3 and R6 are defined herein.

公开(公告)号：US20200331881A1

公开(公告)日：2020-10-22

申请号：US16850171

申请日：2020-04-16

Applicant: Janssen Biotech, Inc.

Inventor： Scott Kuduk ,  Zhuming Zhang ,  Lindsey DeRatt ,  Aihua Wang

IPC: C07D401/04 ,  C07D403/04 ,  C07D471/04 ,  C07D417/14 ,  C07D401/14

Abstract: Disclosed are compounds, compositions and methods for treating diseases, disorders, or medical conditions that are affected by the modulation of DHODH. Such compounds are represented by Formula (I) as follows: wherein R1, R2, R3, R4, X, and Y are defined herein.

公开(公告)号：US20240166622A1

公开(公告)日：2024-05-23

申请号：US17773079

申请日：2020-10-30

Applicant: Janssen Biotech, Inc.

Inventor： Justin Cisar ,  Scott Kuduk ,  Aihua Wang ,  Zhuming Zhang ,  Chao-yuan Wang

IPC: C07D401/04 ,  C07D403/04 ,  C07D413/04

CPC classification number: C07D401/04 ,  C07D403/04 ,  C07D413/04

Abstract: Disclosed are compounds, compositions, and methods for treating diseases, disorders, or medical conditions that are affected by the modulation of DHODH. Such compounds are represented by Formula (I) as follows:




wherein X, Y, R1a, R1b, Z1, Z2, Z3, R2, and R3, are defined herein.

公开(公告)号：US11505536B2

公开(公告)日：2022-11-22

申请号：US16850171

申请日：2020-04-16

Applicant: Janssen Biotech, Inc.

Inventor： Scott Kuduk ,  Zhuming Zhang ,  Lindsey DeRatt ,  Aihua Wang

IPC: C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D417/14 ,  C07D471/04

Abstract: Disclosed are compounds, compositions and methods for treating diseases, disorders, or medical conditions that are affected by the modulation of DHODH. Such compounds are represented by Formula (I) as follows: wherein R1, R2, R3, R4, X, and Y are defined herein.

公开(公告)号：US20220298137A1

公开(公告)日：2022-09-22

申请号：US17742606

申请日：2022-05-12

Applicant: Janssen Biotech, Inc.

Inventor： Scott Kuduk ,  Zhuming Zhang ,  Lindsey DeRatt ,  Aihua Wang

IPC: C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D417/14 ,  C07D471/04

Abstract: Disclosed are compounds, compositions and methods for treating diseases, disorders, or medical conditions that are affected by the modulation of DHODH. Such compounds are represented by Formula (I) as follows: wherein R1, R2, R3, R4, X, and Y are defined herein.

公开(公告)号：US20220089568A1

公开(公告)日：2022-03-24

申请号：US17421741

申请日：2020-01-10

Applicant: Janssen Biotech, Inc.

Inventor： Justin Cisar ,  Scott Kuduk ,  Chao-yuan Wang ,  Yvan Rene Ferdinand Simonnet ,  Colleen Elizabeth Keohane ,  Edgar Jacoby

IPC: C07D401/14

Abstract: Disclosed are compounds, compositions and methods for treating diseases, disorders, or medical conditions that are affected by the modulation of DHODH. Such compounds are represented by Formula (I) as follows: wherein R1a, R1b, R2, and R3, are defined herein.

公开(公告)号：US20220081422A1

公开(公告)日：2022-03-17

申请号：US17428997

申请日：2020-02-06

Applicant: Janssen Biotech, Inc.

Inventor： Justin Cisar ,  Scott Kuduk ,  Zhuming Zhang ,  Aihua Wang ,  Yvan Simonnet

IPC: C07D403/10 ,  C07D471/04 ,  C07D401/10 ,  C07D401/14

Abstract: Disclosed are compounds, compositions and methods for treating diseases, disorders, or medical conditions that are affected by the modulation of DHODH. Embodiments of such compounds are represented by Formula (I) as follows: wherein R1, R2, R3, R4, R5a, R5b, X and Y, are defined herein.