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1.发明授权公开(公告)号：US10301392B2
公开(公告)日：2019-05-28
申请号：US15596609
申请日：2017-05-16
发明人： John Chen , Johan Fransson , Natalie Fursov , Damon Hamel , Thomas Malia , Galina Obmolova , Tatiana Ort , Michael Rycyzyn , Michael Scully , Raymond Sweet , Alexey Teplyakov , John Wheeler , Juan Carlos Almagro
摘要： Human antibodies immunospecific for human CD27 are capable of blocking CD27 binding to its ligand CD70 and neutralizing bioactivity of CD27 including, but not limited to, CD27 intracellular signaling, T-cell proliferation and activation, B-cell proliferation and differentiation, plasmablast formation and alleviation of antibody responses, stimulation of tumor cells by CD70, and the production of soluble mediators from T and B-cells. The antibodies are useful in diagnosing or treating CD27 activity associated diseases and conditions.
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公开(公告)号：US10196440B2
公开(公告)日：2019-02-05
申请号：US15984772
申请日：2018-05-21
发明人： Christopher Alderfer , Dariusz Janecki , Xuesong Liu , Melissa Murdock , Sheng-Jiun Wu , Marc Mercken , Marc Vandermeeren , Thomas Malia
摘要： The present invention relates to anti-PHF-tau antibodies and methods of making and using them.
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公开(公告)号：US20180305445A1
公开(公告)日：2018-10-25
申请号：US15984772
申请日：2018-05-21
发明人： Christopher Alderfer , Dariusz Janecki , Xuesong Liu , Melissa Murdock , Sheng-Jiun Wu , Marc Mercken , Marc Vandermeeren , Thomas Malia
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to anti-PHF-tau antibodies and methods of making and using them.
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公开(公告)号：US10766953B2
公开(公告)日：2020-09-08
申请号：US15923011
申请日：2018-03-16
摘要： Monoclonal anti-PHF-tau antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies and using the antibodies for treating or preventing conditions such as tauopathies.
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公开(公告)号：US10689453B2
公开(公告)日：2020-06-23
申请号：US16382645
申请日：2019-04-12
申请人： Janssen Biotech, Inc
发明人： John Chen , Johan Fransson , Natalie Fursov , Damon Hamel , Thomas Malia , Galina Obmolova , Tatiana Ort , Michael Rycyzyn , Michael Scully , Raymond Sweet , Alexey Teplyakov , John Wheeler , Juan Carlos Almagro
摘要： Human antibodies immunospecific for human CD27 are capable of blocking CD27 binding to its ligand CD70 and neutralizing bioactivity of CD27 including, but not limited to, CD27 intracellular signaling, T-cell proliferation and activation, B-cell proliferation and differentiation, plasmablast formation and alleviation of antibody responses, stimulation of tumor cells by CD70, and the production of soluble mediators from T and B-cells. The antibodies are useful in diagnosing or treating CD27 activity associated diseases and conditions.
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公开(公告)号：US20180265575A1
公开(公告)日：2018-09-20
申请号：US15923011
申请日：2018-03-16
摘要： Monoclonal anti-PHF-tau antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies and using the antibodies for treating or preventing conditions such as tauopathies.
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公开(公告)号：US10000559B2
公开(公告)日：2018-06-19
申请号：US15646865
申请日：2017-07-11
发明人： Christopher Alderfer , Dariusz Janecki , Xuesong Liu , Melissa Murdock , Sheng-Jiun Wu , Marc Mercken , Marc Vandermeeren , Thomas Malia
摘要： The present invention relates to anti-PHF-tau antibodies and methods of making and using them.
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公开(公告)号：US20240141055A1
公开(公告)日：2024-05-02
申请号：US18216074
申请日：2023-06-29
申请人： Janssen Biotech, Inc
发明人： John Chen , Johan Fransson , Natalie Fursov , Damon Hamel , Thomas Malia , Galina Obmolova , Tatiana Ort , Michael Rycyzyn , Michael Scully , Raymond Sweet , Alexey Teplyakov , John Wheeler , Juan Carlos Almagro
IPC分类号： C07K16/28
CPC分类号： C07K16/2878 , C07K16/2896 , A61K2039/505
摘要： Human antibodies immunospecific for human CD27 are capable of blocking CD27 binding to its ligand CD70 and neutralizing bioactivity of CD27 including, but not limited to, CD27 intracellular signaling, T-cell proliferation and activation, B-cell proliferation and differentiation, plasmablast formation and alleviation of antibody responses, stimulation of tumor cells by CD70, and the production of soluble mediators from T and B-cells. The antibodies are useful in diagnosing or treating CD27 activity associated diseases and conditions.
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公开(公告)号：US20190248910A1
公开(公告)日：2019-08-15
申请号：US16382645
申请日：2019-04-12
申请人： Janssen Biotech, Inc
发明人： John Chen , Johan Fransson , Natalie Fursov , Damon Hamel , Thomas Malia , Galina Obmolova , Tatiana Ort , Michael Rycyzyn , Michael Scully , Raymond Sweet , Alexey Teplyakov , John Wheeler , Juan Carlos Almagro
IPC分类号： C07K16/28
摘要： Human antibodies immunospecific for human CD27 are capable of blocking CD27 binding to its ligand CD70 and neutralizing bioactivity of CD27 including, but not limited to, CD27 intracellular signaling, T-cell proliferation and activation, B-cell proliferation and differentiation, plasmablast formation and alleviation of antibody responses, stimulation of tumor cells by CD70, and the production of soluble mediators from T and B-cells. The antibodies are useful in diagnosing or treating CD27 activity associated diseases and conditions.
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公开(公告)号：US20170355758A1
公开(公告)日：2017-12-14
申请号：US15646865
申请日：2017-07-11
申请人： Janssen Biotech, Inc
发明人： Christopher Alderfer , Dariusz Janecki , Xuesong Liu , Melissa Murdock , Sheng-Jiun Wu , Marc Mercken , Marc Vandermeeren , Thomas Malia
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to anti-PHF-tau antibodies and methods of making and using them.
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