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公开(公告)号：US20210277110A1
公开(公告)日：2021-09-09
申请号：US17090961
申请日：2020-11-06
发明人： Raluca Verona , Gordon Powers , Nina Chi Sabins , Nikki A. DeAngelis , Sandra Santulli-Marotto , Karla R. Wiehagen , Sheng-Jiun Wu , Catherine Ferrante , Enrique Zudaire Ubani
摘要： The present invention relates to antibodies specifically binding PD-1, TIM-3 or PD-1 and TIM-3, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing.
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公开(公告)号：US10894830B2
公开(公告)日：2021-01-19
申请号：US15340109
申请日：2016-11-01
发明人： Raluca Verona , Gordon Powers , Nina Chi Sabins , Nikki A DeAngelis , Sandra Santulli-Marotto , Karla R Wiehagen , Sheng-Jiun Wu , Catherine Ferrante , Enrique Zudaire Ubani
摘要： The present invention relates to antibodies specifically binding PD-1, TIM-3 or PD-1 and TIM-3, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing.
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公开(公告)号：US10196440B2
公开(公告)日：2019-02-05
申请号：US15984772
申请日：2018-05-21
发明人： Christopher Alderfer , Dariusz Janecki , Xuesong Liu , Melissa Murdock , Sheng-Jiun Wu , Marc Mercken , Marc Vandermeeren , Thomas Malia
摘要： The present invention relates to anti-PHF-tau antibodies and methods of making and using them.
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公开(公告)号：US20180305445A1
公开(公告)日：2018-10-25
申请号：US15984772
申请日：2018-05-21
发明人： Christopher Alderfer , Dariusz Janecki , Xuesong Liu , Melissa Murdock , Sheng-Jiun Wu , Marc Mercken , Marc Vandermeeren , Thomas Malia
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to anti-PHF-tau antibodies and methods of making and using them.
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公开(公告)号：US09932404B2
公开(公告)日：2018-04-03
申请号：US15345860
申请日：2016-11-08
发明人： Mark Cunningham , Yiqing Feng , Katharine Heeringa , Jinquan Luo , Robert Rauchenberger , Mark Rutz , Lani San Mateo , Robert Sarisky , Raymond Sweet , Fang Teng , Alexey Teplyakov , Sheng-Jiun Wu
IPC分类号： A61K39/395 , C07K16/28 , C07H21/04 , C12N15/117 , C07K14/705 , C12N5/10 , C12N5/12 , C12N15/63 , A61K39/00
CPC分类号： C07K16/2896 , A61K39/39533 , A61K39/3955 , A61K2039/505 , C07H21/04 , C07K14/705 , C07K16/18 , C07K16/28 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C12N5/10 , C12N5/12 , C12N15/117 , C12N15/63 , C12N2310/17 , A61K39/00 , A61K2300/00
摘要： Toll Like Receptor 3 (TLR3) antibody antagonists, polynucleotides encoding TLR3 antibody antagonists or fragments thereof, and methods of making and using the foregoing are disclosed.
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公开(公告)号：US20170253651A1
公开(公告)日：2017-09-07
申请号：US15461886
申请日：2017-03-17
发明人： Yan Chen , Debra Gardner , David M. Knight , Michael W. Lark , Bailin Liang , David M. Marquis , David J. Shealy , Eric Michael Smith , Xioa-yu R. Song , Vedrana Stojanovic-Susulic , Raymond W. Sweet , Susan Tam , Alain P. Vasserot , Sheng-Jiun Wu , Jing Yang
IPC分类号： A61K39/395
CPC分类号： C07K16/248 , A61K2039/505 , A61K2039/54 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Anti-IL-6 antibodies and antirheumatics are useful to treat and suppress IL-6 related conditions, such as rheumatoid arthritis.
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公开(公告)号：US20170066831A1
公开(公告)日：2017-03-09
申请号：US14939624
申请日：2015-11-12
发明人： Karen Duffy , Natalie Fursov , LeRoy Hall , Catherine Healy , Roberta Lamb , Jinquan Luo , Ravi Malaviya , Michael Naso , Michael Pratta , Mark Tornetta , John Wheeler , Sheng-Jiun Wu
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , A61K38/012 , A61K39/3955 , A61K2039/505 , C07K16/44 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to ST2L antagonists, polynucleotides encoding the antagonists or fragments thereof, and methods of making and using the foregoing.
摘要翻译： 本发明涉及ST2L拮抗剂，编码拮抗剂或其片段的多核苷酸，以及制备和使用上述物质的方法。
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公开(公告)号：US09090694B2
公开(公告)日：2015-07-28
申请号：US13798204
申请日：2013-03-13
发明人： Karen Duffy , Natalie Fursov , LeRoy Hall , Catherine Healy , Roberta Lamb , Jinquan Luo , Ravi Malaviya , Michael Naso , Michael Pratta , Mark Tornetta , John Wheeler , Sheng-Jiun Wu
CPC分类号： C07K16/2866 , A61K38/012 , A61K39/3955 , A61K2039/505 , C07K16/44 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to ST2L antagonists, polynucleotides encoding the antagonists or fragments thereof, and methods of making and using the foregoing.
摘要翻译： 本发明涉及ST2L拮抗剂，编码拮抗剂或其片段的多核苷酸，以及制备和使用上述物质的方法。
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公开(公告)号：US20140234304A1
公开(公告)日：2014-08-21
申请号：US14230128
申请日：2014-03-31
发明人： Juan Carlos ALMAGRO , Glenn Mark Anderson , Ellen Chi , Christian Martinez , Gopalan Raghunathan , Ronald Swanson , Alexey Teplyakov , Kam-Fai Tse , Sheng-Jiun Wu , Hong Mimi Zhou
IPC分类号： C07K16/40
CPC分类号： C07K16/40 , A61K2039/505 , C07K16/28 , C07K16/36 , C07K16/464 , C07K2317/24 , C07K2317/34 , C07K2317/41 , C07K2317/524 , C07K2317/55 , C07K2317/565 , C07K2317/72 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The invention relates to a humanized form of an antibody capable of preventing tissue factor (coagulation factor F3) signaling but which does not interfere with Factor VII binding or FX binding to tissue factor and does not prolong coagulation time. The antibody of the invention is useful in treating conditions, such as tumor progression, in which the associated cells express tissue factor and tissue factor signaling occurs.
摘要翻译： 本发明涉及能够预防组织因子（凝血因子F3）信号传导但不干扰因子VII结合或FX与组织因子结合并且不延长凝血时间的抗体的人源化形式。 本发明的抗体可用于治疗相关细胞表达组织因子和组织因子信号传导的病症，例如肿瘤进展。
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公开(公告)号：US20180355043A1
公开(公告)日：2018-12-13
申请号：US16062255
申请日：2016-12-16
发明人： Christian Martinez , Qiang Chen , Melissa Swiecki , Robert Kuhn , Hong Zhou , Karen Duffy , Stephane Becart , Chichi Huang , Xiefan Lin-Schmidt , Sheng-Jiun Wu , Jeffrey Luo , Galina Obmolova , Robin Ernst
IPC分类号： C07K16/28
CPC分类号： C07K16/2833 , C07K2317/21 , C07K2317/56 , C07K2317/92
摘要： The present invention relates antibodies or antigen-binding fragments thereof specifically binding HLA-DR, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing.
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