公开(公告)号：US20220275018A1

公开(公告)日：2022-09-01

申请号：US17616248

申请日：2020-06-11

申请人： Janssen Pharmaceutica NV

发明人： Jonas VERHOEVEN ,  Marta BRAMBILLA ,  Nagaraju CHINTA ,  Jan Julien A. HULLAERT ,  Lucile Marguerite JOUFFROY ,  Lieven MEERPOEL ,  Zeina NEOUCHY ,  Johannes Wilhelmus John F. THURING ,  Guido Alfons F. VERNIEST ,  Johan Maurits WINNE

IPC分类号： C07H23/00 ,  C07H19/16 ,  C07H9/04

摘要： The present invention relates to novel spirobicyclic intermediates useful in the synthesis of spirobicyclic nucleoside analogues.

公开(公告)号：US20200369707A1

公开(公告)日：2020-11-26

申请号：US16769793

申请日：2018-12-06

申请人： Janssen Pharmaceutica NV

发明人： Jonas VERHOEVEN ,  Guido Alfons F. VERNIEST ,  Johannes Wilhelmus John F. THURING ,  Tongfei WU ,  Vineet PANDE ,  Lieven MEERPOEL ,  Dirk BREHMER ,  Weimei SUN ,  Scott E. DENMARK

IPC分类号： C07H19/167

摘要： The present invention relates to novel spirobicyclic analogues of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.