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1.发明申请公开(公告)号：US20190263833A1
公开(公告)日：2019-08-29
申请号：US16336934
申请日：2017-10-02
发明人： Tongfei WU , Dirk BREHMER , Lijs BEKE , An BOECKX , Gaston Stanislas Marcella DIELS , Edward Charles LAWSON , Lieven MEERPOEL , Vineet PANDE , Marcus Cornelis Bernardus Catharina PARADÉ , Wim Bert Griet SCHEPENS , Weimei SUN , Johannes Wilhelmus John F. THURING , Marcel VIELLEVOYE
IPC分类号： C07D519/00 , C07D487/04 , A61P35/00 , A61K9/00
摘要： The present invention relates to novel novel monocyclic and bicyclic ring system substituted carbanucleoside analogues of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
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公开(公告)号：US20200289539A1
公开(公告)日：2020-09-17
申请号：US16082020
申请日：2017-02-24
发明人： Didier Jean-Claude BERTHELOT , Dirk BREHMER , Lijs BEKE , An BOECKX , Gaston Stanislas Marcella DIELS , Ronaldus Arnodus Hendrika Joseph GILISSEN , Edward Charles LAWSON , Vineet PANDE , Marcus Cornells Bernardus Catbarina PARADE , Wim Bert Griet SCHEPENS , Brian Christopher SHOOK , Johannes Wilhelmus John F. THURING , Marcel VIELLEVOYE , Weimei SUN , Tongfei WU , Lieven MEERPOEL
IPC分类号： A61K31/7076 , A61K31/7064 , A61K31/706
摘要： The present invention relates novel substituted nucleoside analogues of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
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公开(公告)号：US20220275018A1
公开(公告)日：2022-09-01
申请号：US17616248
申请日：2020-06-11
发明人： Jonas VERHOEVEN , Marta BRAMBILLA , Nagaraju CHINTA , Jan Julien A. HULLAERT , Lucile Marguerite JOUFFROY , Lieven MEERPOEL , Zeina NEOUCHY , Johannes Wilhelmus John F. THURING , Guido Alfons F. VERNIEST , Johan Maurits WINNE
摘要： The present invention relates to novel spirobicyclic intermediates useful in the synthesis of spirobicyclic nucleoside analogues.
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公开(公告)号：US20230142285A1
公开(公告)日：2023-05-11
申请号：US17604818
申请日：2020-12-17
发明人： Wei CAI , Xuedong DAI , Oliver Alexis Georges QUEROLLE , Johannes Wilhelmus John F. THURING , Yingtao LIU , Lianzhu LIU , Yanping XU , Liqiang FU , Ming LI , Lichao FANG , Xianguin DENG , Qiwu ZHAO , Kangying LI , Alicia Tee Fuay NG , Nicolas Freddy J. DARVILLE , Edward CLEATOR , Gregor Thomas URBANIETZ , William Marc MATON , Vineet PANDA
IPC分类号： C07D487/10 , C07D207/08 , A61P35/00
CPC分类号： C07D487/10 , C07D207/08 , A61P35/00
摘要： The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, pharmaceutical composition comprising such compounds, and their use as menin/MLL protein/protein interaction inhibitors, useful for treating diseases such as cancer, including but not limited to leukemia, myelodysplastic syndrome (MDS), and myeloproliferative neoplasms (MPN); and diabetes.
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公开(公告)号：US20200369707A1
公开(公告)日：2020-11-26
申请号：US16769793
申请日：2018-12-06
发明人： Jonas VERHOEVEN , Guido Alfons F. VERNIEST , Johannes Wilhelmus John F. THURING , Tongfei WU , Vineet PANDE , Lieven MEERPOEL , Dirk BREHMER , Weimei SUN , Scott E. DENMARK
IPC分类号： C07H19/167
摘要： The present invention relates to novel spirobicyclic analogues of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
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