公开(公告)号：US20170233401A1

公开(公告)日：2017-08-17

申请号：US15403741

申请日：2017-01-11

申请人： Janssen Pharmaceutica NV

发明人： Gilles Bignan ,  Peter J. Connolly ,  Ian Hickson ,  Lieven Meerpoel ,  Vineet Pande ,  Zhuming Zhang ,  Jonathan Branch ,  Christian Rocaboy ,  Luis B. Trabalón Escolar

IPC分类号： C07D491/107 ,  A61K31/506 ,  A61K9/00 ,  A61K31/58 ,  A61K31/573 ,  A61K31/4545 ,  C07D405/14 ,  A61K31/4439 ,  C07D401/04 ,  C07D413/14 ,  A61K31/5377 ,  A61K31/55 ,  C07D451/06 ,  A61K31/46 ,  C07D409/14 ,  C07D401/14

CPC分类号： C07D491/107 ,  A61K9/0053 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/46 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/573 ,  A61K31/58 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D451/02 ,  C07D451/06 ,  C07D487/04 ,  C07D491/044 ,  C07D491/048

摘要： Disclosed are compounds, compositions and methods for treating of disorders that are affected by the antagonism of one or more androgen receptor types. Such compounds are represented by Formula (I) as follows: wherein R1 and G are defined herein.

公开(公告)号：US20180298021A1

公开(公告)日：2018-10-18

申请号：US16012160

申请日：2018-06-19

申请人： Janssen Pharmaceutica NV

发明人： Gilles Bignan ,  Peter J. Connolly ,  Ian Hickson ,  Lieven Meerpoel ,  Vineet Pande ,  Zhuming Zhang ,  Jonathan Branch ,  Christian Rocaboy ,  Luis B. Trabalón Escolar

IPC分类号： C07D491/107 ,  A61K31/58 ,  C07D401/14 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/573 ,  A61K9/00 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/46 ,  C07D491/048 ,  C07D491/044 ,  C07D487/04 ,  C07D451/06 ,  C07D451/02 ,  C07D409/14 ,  C07D401/04 ,  C07D413/14 ,  C07D405/14 ,  A61K31/506

摘要： Disclosed are compounds, compositions and methods for treating of disorders that are affected by the antagonism of one or more androgen receptor types. Such compounds are represented by Formula (I) as follows: wherein R1 and G are defined herein.

公开(公告)号：US10981926B2

公开(公告)日：2021-04-20

申请号：US16677906

申请日：2019-11-08

申请人： Janssen Pharmaceutica NV

发明人： Gilles Bignan ,  Peter J. Connolly ,  Ian Hickson ,  Lieven Meerpoel ,  Vineet Pande ,  Zhuming Zhang ,  Jonathan Branch ,  Christian Rocaboy ,  Luis B. Trabalón Escolar

IPC分类号： C07D491/10 ,  C07D491/107 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D401/04 ,  C07D409/14 ,  C07D451/02 ,  C07D451/06 ,  C07D487/04 ,  C07D491/044 ,  C07D491/048 ,  A61K9/00 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/46 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/573 ,  A61K31/58

摘要： Disclosed are compounds, compositions and methods for treating of disorders that are affected by the antagonism of one or more androgen receptor types. Such compounds are represented by Formula (I) as follows: wherein R1 and G are defined herein.

公开(公告)号：US10000502B2

公开(公告)日：2018-06-19

申请号：US15403741

申请日：2017-01-11

申请人： Janssen Pharmaceutica NV

发明人： Gilles Bignan ,  Peter J Connolly ,  Ian Hickson ,  Lieven Meerpoel ,  Vineet Pande ,  Zhuming Zhang ,  Jonathan Branch ,  Christian Rocaboy ,  Luis B Trabalón Escolar

IPC分类号： C07D491/107 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D401/04 ,  C07D409/14 ,  C07D451/02 ,  C07D451/06 ,  C07D487/04 ,  C07D491/044 ,  C07D491/048 ,  A61K9/00 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/46 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/573 ,  A61K31/58

CPC分类号： C07D491/107 ,  A61K9/0053 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/46 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/573 ,  A61K31/58 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D451/02 ,  C07D451/06 ,  C07D487/04 ,  C07D491/044 ,  C07D491/048

摘要： Disclosed are compounds, compositions and methods for treating of disorders that are affected by the antagonism of one or more androgen receptor types. Such compounds are represented by Formula (I) as follows: wherein R1 and G are defined herein.

公开(公告)号：US20190330190A1

公开(公告)日：2019-10-31

申请号：US16440931

申请日：2019-06-13

申请人： Janssen Pharmaceutica NV

发明人： Gilles Bignan ,  Peter J. Connolly ,  Ian Hickson ,  Lieven Meerpoel ,  Vineet Pande ,  Zhuming Zhang ,  Jonathan Branch ,  Christian Rocaboy ,  Luis B. Trabalón Escolar

IPC分类号： C07D401/14 ,  A61K31/58 ,  A61K31/4545 ,  C07D401/12 ,  A61K31/573 ,  A61K31/454

摘要： Disclosed are compounds, compositions and methods for treating of disorders that are affected by the antagonism of one or more androgen receptor types. Such compounds are represented by Formula (I) as follows: wherein R1, R2a, R2b, Z, X, Y, and G are defined herein.