公开(公告)号：US20190337924A1

公开(公告)日：2019-11-07

申请号：US16440937

申请日：2019-06-13

申请人： Janssen Pharmaceutica NV

发明人： Gilles Bignan ,  Peter J Connolly ,  Jan Hickson ,  Lieven Meerpoel ,  Vineet Pande ,  Zhuming Zhang ,  Jonathan Branch ,  Christian Rocaboy ,  Luis B Trabalón Escolar

IPC分类号： C07D401/14 ,  A61K31/58 ,  A61K31/4545 ,  C07D401/12 ,  A61K31/573 ,  A61K31/454

摘要： Disclosed are compounds, compositions and methods for treating of disorders that are affected by the antagonism of one or more androgen receptor types. Such compounds are represented by Formula (I) as follows: wherein R1a, R2a, R2b, Z, X, Y, and G are defined herein.

公开(公告)号：US10000502B2

公开(公告)日：2018-06-19

申请号：US15403741

申请日：2017-01-11

申请人： Janssen Pharmaceutica NV

发明人： Gilles Bignan ,  Peter J Connolly ,  Ian Hickson ,  Lieven Meerpoel ,  Vineet Pande ,  Zhuming Zhang ,  Jonathan Branch ,  Christian Rocaboy ,  Luis B Trabalón Escolar

IPC分类号： C07D491/107 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D401/04 ,  C07D409/14 ,  C07D451/02 ,  C07D451/06 ,  C07D487/04 ,  C07D491/044 ,  C07D491/048 ,  A61K9/00 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/46 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/573 ,  A61K31/58

CPC分类号： C07D491/107 ,  A61K9/0053 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/46 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/573 ,  A61K31/58 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D451/02 ,  C07D451/06 ,  C07D487/04 ,  C07D491/044 ,  C07D491/048

摘要： Disclosed are compounds, compositions and methods for treating of disorders that are affected by the antagonism of one or more androgen receptor types. Such compounds are represented by Formula (I) as follows: wherein R1 and G are defined herein.