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公开(公告)号：US11168068B2
公开(公告)日：2021-11-09
申请号：US16318287
申请日：2017-07-14
发明人： José Ignacio Andrés-Gil , Guy Maurits R. Bormans , Lieven Denis Herwig Declercq , Katleen Fierens , Joseph Elisabeth Leenaerts , Diederik Willem Elisabeth Moechars , Frederik Jan Rita Rombouts , Hartmuth Kolb , Wei Zhang
IPC分类号： C07D401/12 , C07D215/42 , A61K51/04 , A61K31/47 , C07B59/00
摘要： The present invention relates to novel, selective radiolabelled tau ligands which are useful for imaging and quantifying tau aggregates, using positron-emission tomography (PET). The invention is also directed to compositions comprising such compounds, to processes for preparing such compounds and compositions, to the use of such compounds and compositions for imaging a tissue or a subject, in vitro or in vivo, and to precursors of said compounds.
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公开(公告)号：US12006302B2
公开(公告)日：2024-06-11
申请号：US17450212
申请日：2021-10-07
发明人： José Ignacio Andrés-Gil , Guy Maurits R. Bormans , Lieven Denis Herwig Declercq , Katleen Fierens , Joseph Elisabeth Leenaerts , Diederik Willem Elisabeth Moechars , Frederik Jan Rita Rombouts , Hartmuth Kolb , Wei Zhang
IPC分类号： C07D401/12 , A61K51/04 , C07B59/00
CPC分类号： C07D401/12 , A61K51/0455 , C07B59/002 , A61K2123/00
摘要： The present invention relates to novel, selective radiolabelled tau ligands which are useful for imaging and quantifying tau aggregates, using positron-emission tomography (PET). The invention is also directed to compositions comprising such compounds, to processes for preparing such compounds and compositions, to the use of such compounds and compositions for imaging a tissue or a subject, in vitro or in vivo, and to precursors of said compounds.
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公开(公告)号：US20220024896A1
公开(公告)日：2022-01-27
申请号：US17450212
申请日：2021-10-07
发明人： José Ignacio Andrés-Gil , Guy Maurits R. Bormans , Lieven Denis Herwig Declercq , Katleen Fierens , Joseph Elisabeth Leenaerts , Diederik Willem Elisabeth Moechars , Frederik Jan Rita Rombouts , Hartmuth Kolb , Wei Zhang
IPC分类号： C07D401/12 , A61K51/04 , C07B59/00
摘要： The present invention relates to novel, selective radiolabelled tau ligands which are useful for imaging and quantifying tau aggregates, using positron-emission tomography (PET). The invention is also directed to compositions comprising such compounds, to processes for preparing such compounds and compositions, to the use of such compounds and compositions for imaging a tissue or a subject, in vitro or in vivo, and to precursors of said compounds.
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