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公开(公告)号：US10358448B2
公开(公告)日：2019-07-23
申请号：US16043829
申请日：2018-07-24
IPC分类号： C07D471/18 , C07D451/04 , C07D451/06 , C07D451/00 , C07D451/10 , C07D451/12
摘要： The invention provides compounds of Formula 1: and stereoisomers, pharmaceutically acceptable salts and derivatives thereof; and methods of making and using such compounds. The invention includes pharmaceutical compositions containing such compounds, and the use of such compounds in methods of treating conditions, diseases, or disorders.
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公开(公告)号：US10040797B2
公开(公告)日：2018-08-07
申请号：US15254960
申请日：2016-09-01
IPC分类号： C07D471/18 , C07D451/00
摘要： The invention provides compounds of Formula 1: or a stereoisomer, pharmaceutically acceptable salt, or mixture thereof; and methods of making and using such compounds. The invention includes pharmaceutical compositions containing such compounds, and the use of such compounds in methods of treating conditions, diseases, or disorders.
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公开(公告)号：US20180291024A1
公开(公告)日：2018-10-11
申请号：US16005366
申请日：2018-06-11
IPC分类号： C07D471/18 , C07D451/00
CPC分类号： C07D471/18 , C07D451/00 , C07D451/04 , C07D451/06 , C07D451/10 , C07D451/12
摘要： The invention provides compounds of Formula 1: and stereoisomers, pharmaceutically acceptable salts and derivatives thereof; and methods of making and using such compounds. The invention includes pharmaceutical compositions containing such compounds, and the use of such compounds in methods of treating conditions, diseases, or disorders.
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公开(公告)号：US10040795B2
公开(公告)日：2018-08-07
申请号：US15254938
申请日：2016-09-01
IPC分类号： C07D471/18 , C07D451/00
摘要： The invention provides compounds of Formula 1: and stereoisomers, pharmaceutically acceptable salts and derivatives thereof; and methods of making and using such compounds. The invention includes pharmaceutical compositions containing such compounds, and the use of such compounds in methods of treating conditions, diseases, or disorders.
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公开(公告)号：US20170066770A1
公开(公告)日：2017-03-09
申请号：US15254965
申请日：2016-09-01
IPC分类号： C07D471/18
CPC分类号： C07D471/18 , C07D451/00 , C07D451/04 , C07D451/06 , C07D451/10 , C07D451/12
摘要： The invention provides compounds of Formula XXIII: wherein R1 is hydrogen, alkyl, acyl, or silyl, R2 is hydrogen, alkyl, benzyl, acyl, or ester, and R3 is hydrogen, alkyl, an aromatic group, azacyclic, carbocycle, aryl, cycloalkyl, heterocycloalkyl, heterocycle, heteroaryl, heteroalkyl, acyl, or ester, as well as derivatives and stereoisomers, pharmaceutically acceptable salts and derivatives thereof; and methods of making and using such compounds. The invention includes pharmaceutical compositions containing such compounds, and the use of such compounds in methods of treating conditions, diseases, or disorders.
摘要翻译： 其中R1是氢，烷基，酰基或甲硅烷基，R2是氢，烷基，苄基，酰基或酯，R3是氢，烷基，芳基，氮杂环，碳环，芳基，环烷基，杂环烷基，杂环，杂芳基， 杂烷基，酰基或酯，以及衍生物和立体异构体，其药学上可接受的盐和衍生物; 以及制备和使用这些化合物的方法。 本发明包括含有这些化合物的药物组合物，以及这些化合物在治疗疾病或病症的方法中的用途。
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公开(公告)号：US10351565B2
公开(公告)日：2019-07-16
申请号：US16005366
申请日：2018-06-11
IPC分类号： C07D471/18 , C07D451/04 , C07D451/12 , C07D451/00 , C07D451/06 , C07D451/10
摘要： The invention provides compounds of Formula 1: and stereoisomers, pharmaceutically acceptable salts and derivatives thereof; and methods of making and using such compounds. The invention includes pharmaceutical compositions containing such compounds, and the use of such compounds in methods of treating conditions, diseases, or disorders.
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公开(公告)号：US20180327406A1
公开(公告)日：2018-11-15
申请号：US16043829
申请日：2018-07-24
IPC分类号： C07D471/18 , C07D451/00
CPC分类号： C07D471/18 , C07D451/00 , C07D451/04 , C07D451/06 , C07D451/10 , C07D451/12
摘要： The invention provides compounds of Formula 1: and stereoisomers, pharmaceutically acceptable salts and derivatives thereof; and methods of making and using such compounds. The invention includes pharmaceutical compositions containing such compounds, and the use of such compounds in methods of treating conditions, diseases, or disorders.
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公开(公告)号：US20170066767A1
公开(公告)日：2017-03-09
申请号：US15254938
申请日：2016-09-01
IPC分类号： C07D471/18
CPC分类号： C07D471/18 , C07D451/00 , C07D451/04 , C07D451/06 , C07D451/10 , C07D451/12
摘要： The invention provides compounds of Formula 1: and stereoisomers, pharmaceutically acceptable salts and derivatives thereof; and methods of making and using such compounds. The invention includes pharmaceutical compositions containing such compounds, and the use of such compounds in methods of treating conditions, diseases, or disorders.
摘要翻译： 和立体异构体，其药学上可接受的盐和衍生物; 以及制备和使用这些化合物的方法。 本发明包括含有这些化合物的药物组合物，以及这些化合物在治疗疾病或病症的方法中的用途。
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公开(公告)号：US10351566B2
公开(公告)日：2019-07-16
申请号：US16043813
申请日：2018-07-24
IPC分类号： C07D471/18 , C07D451/06 , C07D451/12 , C07D451/00 , C07D451/04 , C07D451/10
摘要： The invention provides compounds of Formula 1: and stereoisomers, pharmaceutically acceptable salts and derivatives thereof; and methods of making and using such compounds. The invention includes pharmaceutical compositions containing such compounds, and the use of such compounds in methods of treating conditions, diseases, or disorders.
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公开(公告)号：US20190112311A1
公开(公告)日：2019-04-18
申请号：US16222852
申请日：2018-12-17
IPC分类号： C07D471/18 , C07D451/12 , C07D451/10 , C07D451/00 , C07D451/04 , C07D451/06
摘要： The invention provides compounds of Formula XXIII: wherein R1 is hydrogen, alkyl, acyl, or silyl, R2 is hydrogen, alkyl, benzyl, acyl, or ester, and R3 is hydrogen, alkyl, an aromatic group, azacyclic, carbocycle, aryl, cycloalkyl, heterocycloalkyl, heterocycle, heteroaryl, heteroalkyl, acyl, or ester, as well as derivatives and stereoisomers, pharmaceutically acceptable salts and derivatives thereof; and methods of making and using such compounds. The invention includes pharmaceutical compositions containing such compounds, and the use of such compounds in methods of treating conditions, diseases, or disorders.
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