公开(公告)号：US10208048B2

公开(公告)日：2019-02-19

申请号：US15570054

申请日：2016-04-27

申请人： Janssen Sciences Ireland UC

发明人： David Francis Alain Lançois ,  Jérôme Émile Georges Guillemont ,  Pierre Jean-Marie Bernard Raboisson ,  Dirk André Emmy Roymans ,  Boris Rogovoy ,  Vadim Bichko ,  Delphine Yvonne Raymonde Lardeau ,  Antoine Benjamin Michaut ,  Anil Koul

IPC分类号： C07D487/04 ,  C07D519/00 ,  A61K31/437 ,  A61K31/519 ,  A61P31/16 ,  A61P31/14

摘要： The invention concerns novel substituted pyrazolo- and triazolo-pyrimidine compounds of formula (I) having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention further concerns pharmaceutical compositions comprising these compounds and the compounds for use in the treatment of respiratory syncytial virus infection.