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公开(公告)号：US10208048B2
公开(公告)日：2019-02-19
申请号：US15570054
申请日：2016-04-27
发明人： David Francis Alain Lançois , Jérôme Émile Georges Guillemont , Pierre Jean-Marie Bernard Raboisson , Dirk André Emmy Roymans , Boris Rogovoy , Vadim Bichko , Delphine Yvonne Raymonde Lardeau , Antoine Benjamin Michaut , Anil Koul
IPC分类号： C07D487/04 , C07D519/00 , A61K31/437 , A61K31/519 , A61P31/16 , A61P31/14
摘要： The invention concerns novel substituted pyrazolo- and triazolo-pyrimidine compounds of formula (I) having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention further concerns pharmaceutical compositions comprising these compounds and the compounds for use in the treatment of respiratory syncytial virus infection.
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![Antibacterial cyclopenta[c]pyrrole substituted 3,4-dihydro-1H-[1,8]naphthyridinones](/abs-image/US/2018/12/18/US10155759B2/abs.jpg.150x150.jpg)
公开(公告)号：US10155759B2
公开(公告)日：2018-12-18
申请号：US15845854
申请日：2017-12-18
发明人： Jerôme Emile Georges Guillemont , David Francis Alain Lançois , Magali Madeleine Simone Motte , Anil Koul , Wendy Mia Albert Balemans , Eric Pierre Alexandre Arnoult
IPC分类号： C07D471/04 , A61K31/495 , A61K31/44 , C07D487/04 , C07D519/00
摘要： The present invention is related to novel compounds of formula (I) that inhibit the activity of the FabI enzyme which are therefore useful in the treatment of bacterial infections. It further relates to pharmaceutical compositions comprising these compounds, and chemical processes for preparing these compounds.
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![Antibacterial cyclopental[C]pyrrole substituted 3,4-dihydro-1H-[1,8]naphthyridinones](/abs-image/US/2017/04/11/US09617262B2/abs.jpg.150x150.jpg)
公开(公告)号：US09617262B2
公开(公告)日：2017-04-11
申请号：US15071612
申请日：2016-03-16
发明人： Jerome Emile Georges Guillemont , David Francis Alain Lancois , Magali Madeleine Simone Motte , Anil Koul , Wendy Mia Albert Balemans , Eric Pierre Alexandre Arnoult
IPC分类号： C07D471/04 , A61K31/44 , C07D487/04 , C07D519/00
CPC分类号： C07D471/04 , C07D487/04 , C07D519/00
摘要： The present invention is related to novel compounds of formula (I) that inhibit the activity of the FabI enzyme which are therefore useful in the treatment of bacterial infections. It further relates to pharmaceutical compositions comprising these compounds, and chemical processes for preparing these compounds.
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![Antibacterial piperidinyl substituted 3,4-dihydro-1H-[1,8]naphthyridinones](/abs-image/US/2017/03/21/US09598407B2/abs.jpg.150x150.jpg)
公开(公告)号：US09598407B2
公开(公告)日：2017-03-21
申请号：US14624452
申请日：2015-02-17
发明人： Jerôme Emile Georges Guillemont , David Francis Alain Lançois , Magali Madeleine Simone Motte , Anil Koul , Wendy Mia Albert Balemans
IPC分类号： A61K31/4375 , C07D221/04 , C07D471/04
CPC分类号： C07D471/04
摘要： The present invention is related to novel compounds of formula (I) that inhibit the activity of the FabI enzyme which are therefore useful in the treatment of bacterial infections. It further relates to pharmaceutical compositions comprising these compounds, and chemical processes for preparing these compounds.
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![Antibacterial cyclopenta[C]pyrrole substituted 3,4-Dihydro-1H-[1,8]naphthyridinones](/abs-image/US/2018/02/06/US09884864B2/abs.jpg.150x150.jpg)
公开(公告)号：US09884864B2
公开(公告)日：2018-02-06
申请号：US15454703
申请日：2017-03-09
发明人： Jerôme Emile Georges Guillemont , David Francis Alain Lançois , Magali Madeleine Simone Motte , Anil Koul , Wendy Mia Albert Balemans , Eric Pierre Alexandre Arnoult
IPC分类号： C07D471/04 , A61K31/50 , A61K31/495 , A61K31/44 , C07D519/00
CPC分类号： C07D471/04 , C07D487/04 , C07D519/00
摘要： The present invention is related to novel compounds of formula (I) that inhibit the activity of the FabI enzyme which are therefore useful in the treatment of bacterial infections. It further relates to pharmaceutical compositions comprising these compounds, and chemical processes for preparing these compounds.
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![ANTIBACTERIAL CYCLOPENTAL[C]PYRROLE SUBSTITUTED 3,4 DIHYDRO-1H-[1,8]NAPHTHYRIDINONES](/abs-image/US/2016/07/07/US20160194324A1/abs.jpg.150x150.jpg)
6.发明申请ANTIBACTERIAL CYCLOPENTAL[C]PYRROLE SUBSTITUTED 3,4 DIHYDRO-1H-[1,8]NAPHTHYRIDINONES 有权取代3,4-二氢-1H- [1,8]萘啶酮的抗菌素环[C]吡咯烷公开(公告)号：US20160194324A1
公开(公告)日：2016-07-07
申请号：US15071612
申请日：2016-03-16
发明人： Jerome Emile Georges Guillemont , David Francis Alain Lancois , Magali Madeleine Simone Motte , Anil Koul , Wendy Mia Albert Balemans , Eric Pierre Alexandre Arnoult
IPC分类号： C07D471/04 , C07D519/00
CPC分类号： C07D471/04 , C07D487/04 , C07D519/00
摘要： The present invention is related to novel compounds of formula (I) that inhibit the activity of the FabI enzyme which are therefore useful in the treatment of bacterial infections. It further relates to pharmaceutical compositions comprising these compounds, and chemical processes for preparing these compounds.
摘要翻译： 本发明涉及抑制因此可用于治疗细菌感染的FabI酶的活性的式（I）化合物。 它还涉及包含这些化合物的药物组合物和用于制备这些化合物的化学方法。
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公开(公告)号：US20150225424A1
公开(公告)日：2015-08-13
申请号：US14419463
申请日：2013-08-09
发明人： Jerôme Emile Georges Guillemont , David Francis Alain Lançois , Magali Madeleine Simone Motte , Wendy Mia Albert Balemans , Anil Koul
IPC分类号： C07D513/14 , C07D498/14 , C07D401/06 , C07D401/14 , C07D405/14 , C07D413/14 , C07D498/04 , C07D471/04
CPC分类号： C07D513/14 , C07D401/06 , C07D401/14 , C07D405/14 , C07D413/14 , C07D471/04 , C07D498/04 , C07D498/14
摘要： The present invention is related to novel compounds of formula (I) that may inhibit the activity of the FabI enzyme, and which are useful in the treatment of bacterial infections. It further relates to pharmaceutical compositions comprising these compounds, and chemical processes for preparing these compounds.
摘要翻译： 本发明涉及可抑制FabI酶的活性的新型式（I）化合物，其可用于治疗细菌感染。 它还涉及包含这些化合物的药物组合物和用于制备这些化合物的化学方法。
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![ANTIBACTERIAL CYCLOPENTA[C]PYRROLE SUBSTITUTED 3,4-DIHYDRO-1H-[1,8]NAPHTHYRIDINONES](/abs-image/US/2017/06/22/US20170174683A1/abs.jpg.150x150.jpg)
公开(公告)号：US20170174683A1
公开(公告)日：2017-06-22
申请号：US15454703
申请日：2017-03-09
发明人： Jerôme Emile Georges Guillemont , David Francis Alain Lançois , Magali Madeleine Simone Motte , Anil Koul , Wendy Mia Albert Balemans , Eric Pierre Alexandre Arnoult
IPC分类号： C07D471/04 , C07D519/00
CPC分类号： C07D471/04 , C07D487/04 , C07D519/00
摘要： The present invention is related to novel compounds of formula (I) that inhibit the activity of the FabI enzyme which are therefore useful in the treatment of bacterial infections. It further relates to pharmaceutical compositions comprising these compounds, and chemical processes for preparing these compounds.
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公开(公告)号：US09428474B2
公开(公告)日：2016-08-30
申请号：US14654186
申请日：2013-12-20
IPC分类号： C07D263/58 , C07D277/82 , C07D277/62 , A61K31/423 , A61K31/428 , A61K45/06
CPC分类号： C07D277/82 , A61K31/423 , A61K31/428 , A61K45/06 , C07D263/58 , C07D277/62 , A61K2300/00
摘要： The present invention relates to the following compounds for use in the treatment of a bacterial infection wherein the integers are as defined in the description. The invention also relates to compounds for use as medicaments, pharmaceutical compositions and some novel compounds.
摘要翻译： 本发明涉及用于治疗细菌感染的以下化合物，其中整体如说明书中所定义。 本发明还涉及用作药物，药物组合物和一些新化合物的化合物。
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![ANTIBACTERIAL CYCLOPENTA[C]PYRROLE SUBSTITUTED 3,4-DIHYDRO-1H-[1,8]NAPHTHYRIDINONES](/abs-image/US/2018/04/19/US20180105525A1/abs.jpg.150x150.jpg)
公开(公告)号：US20180105525A1
公开(公告)日：2018-04-19
申请号：US15845854
申请日：2017-12-18
发明人： Jerôme Emile Georges Guillemont , David Francis Alain Lançois , Magali Madeleine Simone Motte , Anil Koul , Wendy Mia Albert Balemans , Eric Pierre Alexandre Arnoult
IPC分类号： C07D471/04 , C07D519/00 , C07D487/04
CPC分类号： C07D471/04 , C07D487/04 , C07D519/00
摘要： The present invention is related to novel compounds of formula (I) that inhibit the activity of the FabI enzyme which are therefore useful in the treatment of bacterial infections. It further relates to pharmaceutical compositions comprising these compounds, and chemical processes for preparing these compounds.
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