公开(公告)号：US20020095108A1

公开(公告)日：2002-07-18

申请号：US10073084

申请日：2002-02-12

Applicant: Japan Science and Technology Corporation

Inventor： Eishun Tsuchida ,  Hiromi Sakai ,  Hiroto Onuma ,  Shinji Takeoka

IPC: A61M037/00 ,  C02F001/48

CPC classification number: A61K31/525 ,  A61K31/045 ,  A61K31/198 ,  A61K31/7004 ,  A61K31/7016 ,  A61K38/42 ,  A61K47/6445

Abstract: Disclosed is a method and apparatus for regenerating an oxygen-binding ability by reducing the methemoglobin contained in hemoglobin-vesicle by light irradiation. This method comprises adding electron donors such as amino acids, saccharides, alcohols, and/or flavin derivatives in appropriate amounts to the inner aqueous phase of the hemoglobin-vesicle, applying light to the vesicle when the content of methemoglobin increases as a result of oxidation of hemoglobin, thereby reducing the metohemoglobin. In this manner, the oxygen-binding ability is recovered, thereby maintaining the function of the hemoglobin-vesicle.

Abstract translation: 公开了通过光照射还原血红蛋白囊泡中所含的高铁血红蛋白来再生氧结合能力的方法和装置。 该方法包括将适当量的电子给体如氨基酸，糖类和/或黄素衍生物加入到血红蛋白 - 囊泡的内部水相中，当由于氧化而使高铁血红蛋白的含量增加时，向小泡施加光 的血红蛋白，从而减少血红蛋白。 以这种方式，回收氧结合能力，从而保持血红蛋白 - 囊泡的功能。