公开(公告)号：US20020120096A1

公开(公告)日：2002-08-29

申请号：US10083555

申请日：2002-02-27

Applicant: Japan Science and Technology Corporation

Inventor： Eishun Tsuchida ,  Shinji Takeoka ,  Keitaro Sou ,  Haruki Ohkawa

IPC: C08G069/26 ,  C08G065/34

CPC classification number: C07C237/22 ,  C07C229/26 ,  C07C233/47 ,  C07C271/22 ,  C07K5/02 ,  C07K5/0215 ,  C07K7/02 ,  C07K14/001

Abstract: An amphiphilic compound having a dendritic branch structure represented by general formula (I): 1 In the formula (I), R0 is a hydrophilic group; R1 and R2 are independently a hydrophobic group; and n is an integer of 1 to 4. This amphiphilic compound is capable of stably fixing a water-soluble polymer onto a surface structure by taking advantage of intermolecular interaction, thereby enabling the water-soluble polymer to be carried thereon without giving any damage to the function thereof.

Abstract translation: 具有由通式（I）表示的树枝状结构的两亲化合物：在式（I）中，R 0为亲水基团; R1和R2独立地是疏水基团; n是1〜4的整数。该两亲性化合物能够通过利用分子间相互作用而将水溶性聚合物稳定地固定在表面结构上，从而使水溶性聚合物能够在其上承载而不会对 其功能。

公开(公告)号：US20020095108A1

公开(公告)日：2002-07-18

申请号：US10073084

申请日：2002-02-12

Applicant: Japan Science and Technology Corporation

Inventor： Eishun Tsuchida ,  Hiromi Sakai ,  Hiroto Onuma ,  Shinji Takeoka

IPC: A61M037/00 ,  C02F001/48

CPC classification number: A61K31/525 ,  A61K31/045 ,  A61K31/198 ,  A61K31/7004 ,  A61K31/7016 ,  A61K38/42 ,  A61K47/6445

Abstract: Disclosed is a method and apparatus for regenerating an oxygen-binding ability by reducing the methemoglobin contained in hemoglobin-vesicle by light irradiation. This method comprises adding electron donors such as amino acids, saccharides, alcohols, and/or flavin derivatives in appropriate amounts to the inner aqueous phase of the hemoglobin-vesicle, applying light to the vesicle when the content of methemoglobin increases as a result of oxidation of hemoglobin, thereby reducing the metohemoglobin. In this manner, the oxygen-binding ability is recovered, thereby maintaining the function of the hemoglobin-vesicle.

Abstract translation: 公开了通过光照射还原血红蛋白囊泡中所含的高铁血红蛋白来再生氧结合能力的方法和装置。 该方法包括将适当量的电子给体如氨基酸，糖类和/或黄素衍生物加入到血红蛋白 - 囊泡的内部水相中，当由于氧化而使高铁血红蛋白的含量增加时，向小泡施加光 的血红蛋白，从而减少血红蛋白。 以这种方式，回收氧结合能力，从而保持血红蛋白 - 囊泡的功能。

公开(公告)号：US20020137221A1

公开(公告)日：2002-09-26

申请号：US10091440

申请日：2002-03-07

Applicant: Japan Science and Technology Corporation

Inventor： Eishun Tsuchida ,  Hiromi Sakai ,  Kenichi Tomiyama ,  Shinji Takeoka ,  Keitaro Sou

IPC: G01N033/72

CPC classification number: A61K9/0026 ,  A61K31/555 ,  A61K47/54 ,  A61K47/543 ,  A61K47/544 ,  A61K47/60 ,  A61K47/643 ,  A61K47/6445 ,  Y10T436/100833 ,  Y10T436/20 ,  Y10T436/207497 ,  Y10T436/25 ,  Y10T436/2525

Abstract: There is provided a method for preserving an oxygen infusion comprising a suspension containing hemoglobin or a heme derivative contained in molecular assemblies suspended in a aqueous medium, comprising modifying the molecular assemblies with polyoxyethylene, and making the hemoglobin or the heme derivative to a deoxy-type by removing oxygen from the suspension.

Abstract translation: 提供了一种保存氧气输注的方法，其包括含有悬浮在水性介质中的分子组装体中所含的血红蛋白或血红素衍生物的悬浮液，包括用聚氧乙烯改性分子组装体，并使血红蛋白或血红素衍生物变为脱氧型 通过从悬浮液中除去氧气。