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公开(公告)号：US5354761A
公开(公告)日：1994-10-11
申请号：US69660
申请日：1993-06-01
IPC分类号： A61K31/44 , A61K31/4402 , A61K31/4418 , A61P33/02 , C07D213/78 , C07D213/81 , C07D213/83 , C07D401/04
CPC分类号： C07D213/78 , C07D213/81 , C07D213/83
摘要： Compounds of formula I ##STR1## wherein Y, Z, S, S', m, n and R.sub.1 -R.sub.4 are as defined in the description, have valuable pharmaceutical properties and are effective especially against protozoal infections. They are prepared in a manner known per se.
摘要翻译： 其中Y，Z，S，S'，m，n和R 1 -R 4如说明书中所定义的式I化合物（I）具有有价值的药物性质，并且尤其对抗原生动物感染是有效的。 它们是以本身已知的方式准备的。
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公开(公告)号：US5238941A
公开(公告)日：1993-08-24
申请号：US849262
申请日：1992-03-11
IPC分类号： C07C281/18 , C07C337/08 , C07D213/78 , C07D239/30 , C07D401/04
CPC分类号： C07D213/78 , C07C281/18 , C07C337/08 , C07D239/30 , C07D401/04
摘要： Compounds of formula I ##STR1## wherein A, X.sub.1, X.sub.2, X.sub.3, X.sub.4, Y, Z and R.sub.1 to R.sub.6 have the meanings given in the description, have valuable pharmaceutical properties and are effective especially against tumours. They are prepared in a manner known per se.
摘要翻译： 其中A，X 1，X 2，X 3，X 4，Y，Z和R 1至R 6具有说明书中给出的含义的式I化合物（I）具有有价值的药物性质，尤其对肿瘤有效。 它们是以本身已知的方式准备的。
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公开(公告)号：US5064832A
公开(公告)日：1991-11-12
申请号：US568371
申请日：1990-08-16
IPC分类号： A61K31/165 , A61K31/44 , A61K31/4402 , A61K31/4418 , A61K31/4427 , A61K31/505 , A61P35/00 , A61P43/00 , C07C67/00 , C07C233/65 , C07C241/00 , C07C243/38 , C07C257/18 , C07C327/48 , C07D213/78 , C07D213/81 , C07D213/83 , C07D213/84 , C07D213/89 , C07D239/28 , C07D251/22 , C07D401/04
CPC分类号： C07D213/78 , C07D213/81 , C07D213/83 , C07D213/84 , C07D213/89 , C07D239/28
摘要： Compounds of formula I ##STR1## wherein X.sub.1, X.sub.2, X.sub.3, X.sub.4, X.sub.5, X.sub.6, Y, Z and R.sub.1 -R.sub.4 are as defined in the description, have valuable pharmaceutical properties and are especially active against tumors. They are prepared in a manner known per se.
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公开(公告)号：US5376685A
公开(公告)日：1994-12-27
申请号：US58111
申请日：1993-05-07
IPC分类号： C07C281/18 , C07C337/08 , C07D213/78 , C07D239/30 , C07D401/04 , A61K31/15 , C07C251/86
CPC分类号： C07D213/78 , C07C281/18 , C07C337/08 , C07D239/30 , C07D401/04
摘要： Compounds of formula I ##STR1## wherein A, X.sub.1, X.sub.2, X.sub.3, X.sub.4, Y, Z and R.sub.1 to R.sub.6 have the meanings given in the description, have valuable pharmaceutical properties and are effective especially against tumors. They are prepared in a manner known per se.
摘要翻译： 其中A，X 1，X 2，X 3，X 4，Y，Z和R 1至R 6具有说明书中给出的含义的式I化合物（I）具有有价值的药物性质，尤其对肿瘤有效。 它们是以本身已知的方式准备的。
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公开(公告)号：US4971986A
公开(公告)日：1990-11-20
申请号：US324368
申请日：1989-03-15
IPC分类号： A61K31/155 , A61K31/44 , A61K31/4402 , A61K31/4418 , A61K31/4427 , A61K31/505 , A61P33/02 , A61P35/00 , C07C281/06 , C07C281/16 , C07C281/18 , C07C337/08 , C07D213/74 , C07D213/78 , C07D213/81 , C07D239/28 , C07D239/30 , C07D401/04
CPC分类号： C07D213/78 , C07C281/18 , C07C337/08 , C07D239/30 , C07D401/04
摘要： Compounds of formula I ##STR1## wherein A, X.sub.1, X.sub.2, X.sub.3, X.sub.4, Y, Z and R.sub.1 to R.sub.6 have the meanings given in the description, have valuable pharmaceutical properties and are effective especially against tumors. They are prepared in a manner known per se.
摘要翻译： 其中A，X 1，X 2，X 3，X 4，Y，Z和R 1至R 6具有说明书中给出的含义的式I化合物（I）具有有价值的药物性质，尤其对肿瘤有效。 它们是以本身已知的方式准备的。
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公开(公告)号：US4968804A
公开(公告)日：1990-11-06
申请号：US375760
申请日：1989-07-05
IPC分类号： A61K31/165 , A61K31/44 , A61K31/4402 , A61K31/4418 , A61K31/4427 , A61K31/505 , A61P35/00 , A61P43/00 , C07C67/00 , C07C233/65 , C07C241/00 , C07C243/38 , C07C257/18 , C07C327/48 , C07D213/78 , C07D213/81 , C07D213/83 , C07D213/84 , C07D213/89 , C07D239/28 , C07D251/22 , C07D401/04
CPC分类号： C07D213/78 , C07D213/81 , C07D213/83 , C07D213/84 , C07D213/89 , C07D239/28
摘要： Compounds of formula I ##STR1## wherein X.sub.1, X.sub.2, X.sub.3, X.sub.4, X.sub.5, X.sub.6, Y, Z and R.sub.1 -R.sub.4 are as defined in the description, have valuable pharmaceutical properties and are especially active against tumours. They are prepared in a manner known per se.
摘要翻译： 式I的化合物其中X 1，X 2，X 3，X 4，X 5，X 6，Y，Z和R 1 -R 4如说明书中所定义，具有有价值的药物性质，并且对肿瘤特别有活性。 它们是以本身已知的方式准备的。
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7.发明授权
公开(公告)号：US5118709A
公开(公告)日：1992-06-02
申请号：US574991
申请日：1990-08-29
IPC分类号： A61K31/155 , A61K31/44 , A61K31/4402 , A61K31/4418 , A61K31/4427 , A61K31/505 , A61P33/02 , A61P35/00 , C07C281/06 , C07C281/16 , C07C281/18 , C07C337/08 , C07D213/74 , C07D213/78 , C07D213/81 , C07D239/28 , C07D239/30 , C07D401/04
CPC分类号： C07D213/78 , C07C281/18 , C07C337/08 , C07D239/30 , C07D401/04
摘要： Compounds of formula I ##STR1## wherein A, X.sub.1, X.sub.2, X.sub.3, X.sub.4, Y, Z and R.sub.1 to R.sub.6 have the meanings given in the description, have valuable pharmaceutical properties and are effective especially against tumours. They are prepared in a manner known per se.
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公开(公告)号：US5639911A
公开(公告)日：1997-06-17
申请号：US485248
申请日：1995-06-07
申请人： Jaroslav Stanek , Jorg Frei , Giorgio Caravatti
发明人： Jaroslav Stanek , Jorg Frei , Giorgio Caravatti
IPC分类号： C07C281/12 , C07C281/18 , C07C337/08 , C07C281/00
CPC分类号： C07C337/08 , C07C281/12 , C07C281/18 , C07C2102/06 , C07C2102/08
摘要： Compounds of formula I ##STR1## wherein A, X, Z and R.sub.1 -R.sub.5 are as defined in the description, and their salts have valuable pharmaceutical properties and are effective especially against tumours. They are prepared in a manner known per se.
摘要翻译： 式I的化合物其中A，X，Z和R 1 -R 5如说明书中所定义，其盐具有有价值的药物性质，尤其对肿瘤有效。 它们是以本身已知的方式准备的。
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公开(公告)号：US5461076A
公开(公告)日：1995-10-24
申请号：US346964
申请日：1994-11-30
申请人： Jaroslav Stanek , Jorg Frei , Giorgio Caravatti
发明人： Jaroslav Stanek , Jorg Frei , Giorgio Caravatti
IPC分类号： C07C281/12 , C07C281/18 , C07C337/08 , A61K31/15 , A61K31/155 , C07C281/16
CPC分类号： C07C337/08 , C07C281/12 , C07C281/18 , C07C2102/06 , C07C2102/08
摘要： Compounds of formula I ##STR1## wherein A, X, Z and R.sub.1 -R.sub.5 are as defined in the description, and their salts have valuable pharmaceutical properties and are effective especially against tumors. They are prepared in a manner known per se.
摘要翻译： 式I的化合物其中A，X，Z和R 1 -R 5如说明书中所定义，其盐具有有价值的药物性质，尤其对肿瘤有效。 它们是以本身已知的方式准备的。
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公开(公告)号：US5395855A
公开(公告)日：1995-03-07
申请号：US218854
申请日：1994-03-28
申请人： Jaroslav Stanek , Jorg Frei , Giorgio Caravatti
发明人： Jaroslav Stanek , Jorg Frei , Giorgio Caravatti
IPC分类号： C07C281/12 , C07C281/18 , C07C337/08 , A61K31/15 , A61K31/155 , C07C281/16
CPC分类号： C07C337/08 , C07C281/12 , C07C281/18 , C07C2102/06 , C07C2102/08
摘要： Compounds of formula I ##STR1## wherein A, X, Z and R.sub.1 -R.sub.5 are as defined in the description, and their salts have valuable pharmaceutical properties and are effective especially against tumors. They are prepared in a manner known per se.
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