公开(公告)号：US20080317830A1

公开(公告)日：2008-12-25

申请号：US11768053

申请日：2007-06-25

申请人： Jay A. Goldstein ,  Bernard Grubstein ,  Michael Rothman ,  Whe-Yong Lo ,  Patrea L. Pabst

发明人： Jay A. Goldstein ,  Bernard Grubstein ,  Michael Rothman ,  Whe-Yong Lo ,  Patrea L. Pabst

IPC分类号： A61K33/24 ,  A61K33/08 ,  A61K33/30 ,  A61L15/18 ,  A61K33/12

CPC分类号： A61K33/08 ,  A61K33/06 ,  A61K33/24 ,  A61K33/30 ,  A61L15/18 ,  A61L26/0004

摘要： Compositions for the treatment of wounds and/or scars are described herein. The compositions contain between 1 and up to 30% by weight, more preferably between 1 and 20%, most preferably between about 5 and 10% by weight particles, such as titanium dioxide or a similar material in a pharmaceutically acceptable base or carrier, such as petrolatum. The compositions are less greasy than petrolatum alone, and thus are more aesthetically pleasing. The compositions exhibit occlusive properties comparable to petrolatum. The compositions are absorbed into the skin, unlike petrolatum, and exhibit significant wound healing characteristics not observed with petrolatum alone. In one embodiment, the pharmaceutically acceptable base is petrolatum and the particles are titanium dioxide. The compositions can be used to treat complex, hard to heal wounds, such as diabetic ulcers; pressure sores, such as bed sores; lacerations; bite wounds; burns; penetrating wounds; surgical wounds, etc. The composition can also be used to promote normal healing of scar tissue. The compositions can also be used for the topical delivery of one or more active agent. The compositions can be used to reduce fine lines and wrinkles, and to rehydrate skin or to treat dry skin.

摘要翻译： 本文描述了用于治疗伤口和/或伤痕的组合物。 组合物含有1至高达30重量％，更优选1至20重量％，最优选约5至10重量％的颗粒，例如二氧化钛或药学上可接受的碱或载体中的相似材料，例如 作为凡士林。 组合物比单独的凡士林油脂少，因此更美观。 该组合物表现出与凡士林相当的闭塞性质。 组合物被吸收到皮肤中，与凡士林不同，并且表现出明显的伤口愈合特征，单独用凡士林观察不到。 在一个实施方案中，药学上可接受的碱是凡士林，并且颗粒是二氧化钛。 组合物可用于治疗复杂的难愈合伤口，例如糖尿病性溃疡; 压疮，如褥疮; 撕裂 咬伤 烧伤 穿透伤口; 手术伤口等。组合物也可用于促进瘢痕组织的正常愈合。 组合物也可用于局部递送一种或多种活性剂。 该组合物可用于减少细纹和皱纹，并使皮肤脱水或治疗干性皮肤。