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6 条记录 (耗时 0.018 秒)

    Novel Methods Using Pyridine Derivatives
    1.
    发明申请
    Novel Methods Using Pyridine Derivatives 审中-公开

    公开(公告)号：US20080234325A1

    公开(公告)日：2008-09-25

    申请号：US10311833

    申请日：2001-06-19

    申请人： John Ieni ,  Jay Barth ,  Robert M. Niecestro

    发明人： John Ieni ,  Jay Barth ,  Robert M. Niecestro

    IPC分类号： A61K31/4439 ,  A61P1/00

    CPC分类号： A61K31/4439 ,  Y02A50/411

    摘要： The invention provides methods of treating and preventing asthma, laryngitis, symptomatic gastroesophageal reflux disease, pregnancy-induced gastroesophageal reflux disease, noncardiac chest pains, coughing, apnea, dyspepsia, inflammatory bowel disease, irritable bowel syndrome, gastritis, stress ulcers, bleeding peptic ulcers, acute gastrointestinal bleeding, infectious enteritis, collagenous colitis, lymphocytic colitis, chronic diarrhea in immunocompromised patients, esophageal ulcers in immunocompromised patients, idiopathic gastric acid hypersecretion, gastroparesis, gastrointestinal motility disorders, Zollinger-Ellison syndrome, short bowel syndrome, emesis, regurgitation, early satiety, chronic sore throat, abdominal pain, abdominal bloating, nausea, sour stomach, diarrhea, constipation, bacterial infections, refractory ulcers, gastrointestinal disorders induced by NSAIDs, Barrett's esophagus, gastrointestinal disorders caused by steroids, gastrointestinal disorders induced by cholinergic compounds, and fungal or viral-induced ulcers in the gastrointestinal tract by administering a therapeutically effective amount of at least one of the pyridine derivatives of the invention to a patient in need thereof. The invention also provides on demand relief of symptoms associated with gastroesophageal reflux disease (GERD), and provides relief from symptoms caused by the consumption of excessive amounts of food and/or alcohol by administering a therapeutically effective amount of at least one of the pyridine derivatives of the invention to a patient in need thereof. The invention also provides methods for treating parasitic infections, such as malaria, by administering a therapeutically effective amount of at least one of the pyridine derivatives of the invention to a patient in need thereof. In preferred embodiments, the pyridine derivative of the invention is rabeprazole, a pharmaceutically acceptable salt thereof, or a stereoisomer thereof.

    Compositions and methods using proton pump inhibitors
    2.
    发明申请
    Compositions and methods using proton pump inhibitors 审中-公开
    使用质子泵抑制剂的组合物和方法

    公开(公告)号：US20060024238A1

    公开(公告)日：2006-02-02

    申请号：US10988586

    申请日：2004-11-16

    申请人： Jay Barth ,  John Ieni

    发明人： Jay Barth ,  John Ieni

    IPC分类号： A61L9/04 ,  A61K31/724 ,  A61K31/4439

    CPC分类号： A61K45/06 ,  A61K9/0043 ,  A61K9/7023 ,  A61K33/245 ,  A61K2300/00

    摘要： The invention provides methods for treating and preventing gastrointestinal disorders, viral infections, fungal infections, Whipple's disease, sleep disorders, sleep apnea, iron deficiency anemia, asthma, nasal airway resistance, cystic fibrosis, pancreatitis, chemotherapy-induced emesis, radiation-induced injury to the gastrointestinal tract, epilepsy, middle ear infections, obesity, hiatal hernia, anorexia, bulimia, dental decay, post-operative aspiration, migraines and other disorders by administering to a patient a therapeutically effective amount of at least one proton pump inhibitor. In other embodiments, the proton pump inhibitor can be administered with one or more histamine antagonists, antacids, bismuth compounds, anti-viral agents, anti-fungal agents, NSAIDs, steroids, cyclodextrins, cyclodextrin derivatives, and migraine drugs. In other embodiments, the invention provides nasally or transdermally administrable formulations comprising at least one proton pump inhibitor and, optionally, one or more histamine antagonists, antacids, bismuth compounds, anti-viral agents, anti-fungal agents, NSAIDs, steroids, cyclodextrins, cyclodextrin derivatives, and migraine drugs.

    摘要翻译： 本发明提供了治疗和预防胃肠道疾病，病毒感染，真菌感染，惠普病，睡眠障碍，睡眠呼吸暂停，缺铁性贫血，哮喘，鼻气道阻力，囊性纤维化，胰腺炎，化疗诱发呕吐，放射诱导损伤 通过向患者施用治疗有效量的至少一种质子泵抑制剂，向胃肠道，癫痫，中耳感染，肥胖症，海拉氏疝气，厌食症，贪食症，牙齿衰退，术后抽吸，偏头痛和其它障碍。 在其它实施方案中，质子泵抑制剂可以与一种或多种组胺拮抗剂，抗酸剂，铋化合物，抗病毒剂，抗真菌剂，NSAID，类固醇，环糊精，环糊精衍生物和偏头痛药物一起施用。 在其它实施方案中，本发明提供了包含至少一种质子泵抑制剂和任选的一种或多种组胺拮抗剂，抗酸剂，铋化合物，抗病毒剂，抗真菌剂，NSAIDs，类固醇，环糊精， 环糊精衍生物和偏头痛药物。

    Novel methods using aminobenzoic acid compounds
    5.
    发明申请
    Novel methods using aminobenzoic acid compounds 审中-公开
    使用氨基苯甲酸化合物的新方法

    公开(公告)号：US20080070944A1

    公开(公告)日：2008-03-20

    申请号：US11902338

    申请日：2007-09-20

    申请人： Jay Barth ,  Kathleen Lomax ,  Scott Fields ,  Mindell Seidlin

    发明人： Jay Barth ,  Kathleen Lomax ,  Scott Fields ,  Mindell Seidlin

    IPC分类号： A61K31/439 ,  A61P3/04

    CPC分类号： A61K31/46

    摘要： The invention provides safe and effective methods for treating and/or preventing gastrointestinal disorders, psychiatric disorders, learning disabilities, Tourette's syndrome, obesity, epilepsy, post-menopausal syndrome, pre-menstrual syndrome, asthma, laryngitis and/or migraines by administering to a patient in need thereof at least one aminobenzoic acid compound. The aminobenzoic acid compound can optionally be administered in combination with other medications that are useful for the disease being treated.

    摘要翻译： 本发明提供了安全和有效的治疗和/或预防胃肠道疾病，精神病学，学习障碍，图雷特综合征，肥胖症，癫痫，绝经后综合征，月经前症状，哮喘，喉炎和/或偏头痛的方法， 需要患者的至少一种氨基苯甲酸化合物。 氨基苯甲酸化合物可任选地与可用于所治疗疾病的其它药物组合施用。

    Novel methods using aminobenzoic acid compounds
    6.
    发明申请
    Novel methods using aminobenzoic acid compounds 审中-公开
    使用氨基苯甲酸化合物的新方法

    公开(公告)号：US20070015789A1

    公开(公告)日：2007-01-18

    申请号：US11332711

    申请日：2006-01-11

    申请人： Jay Barth ,  Kathleen Lomax ,  Scott Fields ,  Mindell Seidlin

    发明人： Jay Barth ,  Kathleen Lomax ,  Scott Fields ,  Mindell Seidlin

    IPC分类号： A61K31/46

    CPC分类号： A61K31/46

    摘要： The invention provides safe and effective methods for treating and/or preventing gastrointestinal disorders, psychiatric disorders, learning disabilities, Tourette's syndrome, obesity, epilepsy, post-menopausal syndrome, pre-menstrual syndrome, asthma, laryngitis and/or migraines by administering to a patient in need thereof at least one aminobenzoic acid compound. The aminobenzoic acid compound can optionally be administered in combination with other medications that are useful for the disease being treated.

    摘要翻译： 本发明提供了安全和有效的治疗和/或预防胃肠道疾病，精神病学，学习障碍，图雷特综合征，肥胖症，癫痫，绝经后综合征，月经前症状，哮喘，喉炎和/或偏头痛的方法， 需要患者的至少一种氨基苯甲酸化合物。 氨基苯甲酸化合物可任选地与可用于所治疗疾病的其它药物组合施用。