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    COMPOSITIONS AND METHODS FOR TREATING A SARS-COV-2 INFECTION
    1.
    发明公开
    COMPOSITIONS AND METHODS FOR TREATING A SARS-COV-2 INFECTION 审中-公开

    公开(公告)号：US20230218663A1

    公开(公告)日：2023-07-13

    申请号：US18000491

    申请日：2021-05-31

    申请人： THE UNIVERSITY OF HONG KONG

    发明人： Hongzhe SUN ,  Kwok-Yung YUEN ,  Shuofeng YUAN ,  Runming WANG ,  Hongyan LI ,  Fuk-Woo CHAN ,  Tianfan CHENG ,  Suyu WANG

    IPC分类号： A61K33/245 ,  A61P31/14 ,  A61K45/06

    CPC分类号： A61K33/245 ,  A61P31/14 ,  A61K45/06 ,  A61K9/0053

    摘要： Compositions and methods for treating a subject for a SARS-CoV-2 infection in a subject in need thereof are disclosed. The composition includes one or more Bismuth (III)-containing compounds, an analog thereof, or pharmaceutically acceptable salt thereof in a pharmaceutically acceptable carrier, and are used alone or in combination with a thiol-containing small molecule compound. Exemplary Bismuth (III)-containing compounds include Colloidal Bismuth Subcitrate (CBS); ranitidine bismuth citrate (RBC); Bi (TPP) (TPP: tetraphenylporphyrinate); and Bi (TPyP) (TPyP: tetra (4-pyridyl) porphyrin). The disclosed compounds and compositions can be used to treat a SARS-CoV-2 infection in a subject in need thereof. The compositions can be administered to a subject presently suffering from an infection of the SARS-CoV-2, who is exhibiting one or more symptoms of COVID-19. The compositions can also be administered to a subject that has been exposed to the SARS-CoV-2 but is asymptomatic.

    BISMUTH(III) COMPLEXES AS ADJUVANTS IN THE TREATMENT OF CANCER USING PLATINUM-BASED CHEMOTHERAPY
    5.
    发明申请
    BISMUTH(III) COMPLEXES AS ADJUVANTS IN THE TREATMENT OF CANCER USING PLATINUM-BASED CHEMOTHERAPY 审中-公开
    BISMUTH（III）复合物作为治疗使用基于铂基化疗的癌症的辅助治疗

    公开(公告)号：US20170014448A1

    公开(公告)日：2017-01-19

    申请号：US15210019

    申请日：2016-07-14

    申请人： THE UNIVERSITY OF HONG KONG

    发明人： Hongzhe Sun ,  Chi-Fung Godfrey Chan ,  Shing Chan ,  Runming Wang

    IPC分类号： A61K33/24 ,  A61K33/30

    CPC分类号： A61K33/24 ,  A61K33/245 ,  A61K33/30 ,  A61K45/06 ,  A61K2300/00

    摘要： The present disclosure relates to methods of using cisplatin active agents in which reduced organ toxicity is observed are provided. In the subject methods, an effective amount is administrated to the host before administration of an effective amount of cisplatin active agents. The cisplatin toxicity reducing agent comprising of stable bismuth(III) complexes or pharmaceutically acceptable salts reduces the levels of undesired toxicity of cisplatin active agents without compromising their anticancer activity. Also provided are methods for use in practicing the subject methods in the treatment of different disease conditions.

    摘要翻译： 本公开内容涉及使用顺铂活性剂的方法，其中观察到器官毒性降低。 在本方法中，在施用有效量的顺铂活性剂之前，向宿主施用有效量。 包含稳定的铋（III）配合物或药学上可接受的盐的顺铂毒性降低剂降低顺铂活性剂的不期望的毒性水平，而不损害其抗癌活性。 还提供了用于实践治疗不同疾病状况的受试方法的方法。

    Method based on bismuth ion for the treatment and prevention of a disease caused by a Shiga toxin
    7.
    发明授权
    Method based on bismuth ion for the treatment and prevention of a disease caused by a Shiga toxin 有权
    基于铋离子治疗和预防志贺毒素引起的疾病的方法

    公开(公告)号：US09468653B2

    公开(公告)日：2016-10-18

    申请号：US13503818

    申请日：2011-10-10

    申请人： Hector Manuel Fernandez

    发明人： Hector Manuel Fernandez

    IPC分类号： A61K33/24 ,  A61K31/29 ,  A61K31/618

    CPC分类号： A61K33/245 ,  A61K9/06 ,  A61K31/29 ,  A61K31/618 ,  Y02A50/473

    摘要： The present invention relates to the a bismuth-based composition, particularly involving the use of bismuth ions, particularly the Bi+3 ion, for prevention and/or treatment of the haemolytic uremic syndrome, with the invention also relating to the use of a bismuth ion in the manufacture of a medicament for the prevention and/or treatment of an infection caused by a Shiga-toxin producing Escherichia coli strain, as well as to a method for preventing and/or treating the haemolytic uremic syndrome comprising administering bismuth ions to a patient in need thereof, and a method for inhibiting dissemination of the gene encoding virulence factors of a Shiga-toxin producing Escherichia coli strain in animals and humans.

    摘要翻译： 本发明涉及一种铋基组合物，特别涉及使用铋离子，特别是Bi + 3离子来预防和/或治疗溶血性尿毒症综合征，本发明还涉及使用铋 制备用于预防和/或治疗由产志贺毒素产生的大肠杆菌菌株引起的感染的药物的方法，以及用于预防和/或治疗溶血性尿毒综合征的方法，其包括将铋离子施用于 需要的患者，以及用于抑制编码在动物和人类中产生志贺毒素的大肠杆菌菌株的毒力因子的编码基因的扩散的方法。