公开(公告)号：US06588431B1

公开(公告)日：2003-07-08

申请号：US09913017

申请日：2001-09-28

申请人： Jay M. Meythaler ,  Jean Peduzzi ,  Evangelos Eleftheriou

发明人： Jay M. Meythaler ,  Jean Peduzzi ,  Evangelos Eleftheriou

IPC分类号： A61B1900

CPC分类号： G09B23/286

摘要： An apparatus for simulating human traumatic brain injury in an animal, said apparatus comprising a support having an aperture having end walls and side walls disposed therein; a sliding element slidingly engaged with said side walls of said aperture, said sliding element having a retainer disposed thereon for receiving an animal holder therein; and a crank arm operatively connected to both said sliding element and an actuator mechanism. There is also disclosed a method of simulating human traumatic brain injury in an animal which includes the steps of providing an animal and repeatedly laterally displacing the animal in a reciprocal manner in order to cause acceleration and deceleration of the animal laterally to cause the animal's brain to be correspondingly accelerated and decelerated thereby causing traumatic brain injury. A method of simulating human spinal cord injury in an animal, said method comprising the steps of providing a vertebrate animal having an invertebral space and a spinal cord; causing an opening in the animal at the invertebral space to the interior surface of the spinal cord; inserting a deflated balloon embolectomy catheter into the opening, and rapidly inflating the balloon catheter to cause the balloon catheter to expand and contact the spinal cord whereby the contact causes injury to the spinal cord.

摘要翻译： 一种用于在动物中模拟人类创伤性脑损伤的装置，所述装置包括具有其中设置有端壁和侧壁的孔的支撑件; 与所述孔的所述侧壁滑动地接合的滑动元件，所述滑动元件具有设置在其上的用于在其中容纳动物保持器的保持器; 以及可操作地连接到所述滑动元件和致动器机构的曲柄臂。 还公开了一种在动物中模拟人类创伤性脑损伤的方法，其包括提供动物并以相互的方式重复地横向移动动物的步骤，以使动物横向加速和减速以使动物的大脑 相应地加速和减速，从而引起创伤性脑损伤。 一种在动物中模拟人脊髓损伤的方法，所述方法包括以下步骤：提供具有椎间隙和脊髓的脊椎动物; 导致在脊椎空间的动物的开口到脊髓的前表面; 将放气的气囊插入导管插入开口中，并迅速充气气囊导管，使气囊导管膨胀并接触脊髓，由此接触会对脊髓造成伤害。

公开(公告)号：US20110021469A1

公开(公告)日：2011-01-27

申请号：US12664503

申请日：2008-06-13

申请人： Jay M. Meythaler ,  Stephen M. Tuel

发明人： Jay M. Meythaler ,  Stephen M. Tuel

IPC分类号： A61K31/197 ,  A61P25/00 ,  A61K31/485 ,  A61K31/4168 ,  A61K31/415 ,  A61K31/60

CPC分类号： A61K45/06 ,  A61K9/0019 ,  A61K31/192 ,  A61K31/195 ,  A61K47/02

摘要： A high concentration baclofen solution is provided suitable for therapeutic use in a medical setting. A high concentration solution of baclofen in multivalent physiological ion solution such as artificial cerebrospinal fluid is provided with concentrations of baclofen of 10 mg/ml. Artificial cerebrospinal fluid is particularly advantageous as a baclofen solvent. A medical package is also provided for baclofen delivery to patients suffering from spasticity.

摘要翻译： 提供适合于医疗环境中治疗用途的高浓度巴氯芬溶液。 在多价生理离子溶液（如人造脑脊液）中的高浓度巴氯芬溶液中提供了浓度为10mg / ml的巴氯芬。 人造脑脊液作为巴氯芬溶剂是特别有利的。 还提供了药物包装，用于将巴氯芬递送给患有痉挛症的患者。

公开(公告)号：US07014624B2

公开(公告)日：2006-03-21

申请号：US10443210

申请日：2003-05-22

申请人： Jay M. Meythaler ,  Jean D. Peduzzi-Nelson ,  Landon C. Miller

发明人： Jay M. Meythaler ,  Jean D. Peduzzi-Nelson ,  Landon C. Miller

IPC分类号： A61F7/12 ,  H05B3/00 ,  A61M31/00 ,  A61M25/00 ,  A61M25/18

CPC分类号： A61M27/006 ,  A61B5/031 ,  A61M5/14 ,  A61M5/1408 ,  A61M25/00 ,  A61M2205/3368 ,  A61M2205/50 ,  A61M2205/75 ,  A61M2210/0693 ,  A61M2230/50

摘要： A central nervous system (CNS) catheter assembly adapted for use as a ventriculostomy catheter and a spinal catheter includes a catheter body defining at least one lumen therethrough having a drug delivery branch and a monitoring/sensing branch. The drug delivery branch and the monitoring/sensing second branch are in fluid communication with the lumen. Openings are disposed in fluid communication with the lumen and being located at proximal ends of the drug delivery branch and the monitoring/sensing branch. Another opening is disposed at a distal end of the main body. The assembly further includes a component such as an intracranial pressure/osmotic pressure monitoring system, a fluid drainage system, an attachable introduction aid, a patient surface attachment aid, a micromanipulator and a comprehensive intracranial pressure evaluation and relief system. The assembly optionally includes a filter assembly containing a proton exchange membrane.

摘要翻译： 适于用作脑室造口术导管和脊柱导管的中枢神经系统（CNS）导管组件包括限定穿过其中的至少一个腔的导管主体，其具有药物输送分支和监测/感测分支。 药物输送分支和监测/感测第二分支与管腔流体连通。 开口设置成与内腔流体连通并且位于药物输送支路和监测/感测支路的近端处。 另一个开口设置在主体的远端。 组件还包括诸如颅内压/渗透压监测系统，流体排出系统，可附接引入辅助装置，患者表面附接辅助装置，显微操纵器和综合颅内压评估和释放系统的部件。 组件可选地包括含有质子交换膜的过滤组件。

公开(公告)号：US06682508B1

公开(公告)日：2004-01-27

申请号：US09914801

申请日：2001-12-03

申请人： Jay M. Meythaler ,  Jean Peduzzi ,  Landon C. Miller

发明人： Jay M. Meythaler ,  Jean Peduzzi ,  Landon C. Miller

IPC分类号： A61M500

CPC分类号： A61M25/00 ,  A61M5/14 ,  A61M2210/0693 ,  A61M2230/50

摘要： A central nervous system (CNS) catheter assembly (20) adapted for use as a ventriculostomy catheter and a spinal catheter includes a catheter body (28) defining at least one lumen (30) therethrough having a drug delivery branch (22) and a monitoring/sensing branch (24). The drug delivery branch (22) and the monitoring/sensing second branch (24) are in fluid communication with the lumen (30). The assembly further includes a filter assembly (36) disposed in fluid communication with the drug delivery branch (22) and a valve assembly (54) disposed in fluid communication with the monitoring/sensing branch (24). Also in accordance with the present invention, there is provided a temperature control system (170) for use in controlling the temperature of a location within the central nervous system such as the brain or the spinal cord. The system further includes a pump controller (180), a central processing unit or controller (194), a temperature sensing element (184), and a power supply (194) all operatively connected to the temperature control mechanism.

摘要翻译： 适于用作脑室造口术导管和脊柱导管的中枢神经系统（CNS）导管组件（20）包括导管主体（28），其限定穿过其中的至少一个内腔（30），其具有药物输送分支（22）和监测 /感测支路（24）。 药物输送分支（22）和监测/感测第二分支（24）与内腔（30）流体连通。 组件还包括设置成与药物输送分支（22）流体连通的过滤器组件（36）和与监测/感测分支（24）流体连通地设置的阀组件（54）。 还根据本发明，提供了一种用于控制中枢神经系统（例如脑或脊髓）内的位置的温度的温度控制系统（170）。 该系统还包括全部可操作地连接到温度控制机构的泵控制器（180），中央处理单元或控制器（194），温度感测元件（184）和电源（194）。

公开(公告)号：US20110003868A1

公开(公告)日：2011-01-06

申请号：US12882992

申请日：2010-09-15

申请人： Jay M. Meythaler

发明人： Jay M. Meythaler

IPC分类号： A61K31/4409 ,  A61K31/44 ,  A61P25/28

CPC分类号： A61K31/44

摘要： A process for treating neuropathy includes administration to a patient suffering from a neuropathy more than 5 and less than 18 mg of aminopyridine in a dose. The aminopyridine is formulated in an immediate release formulation. At least two such doses are provided per day to create spike serum plasma levels of aminopyridine sufficient to drive the aminopyridine across the blood-nerve barrier.

摘要翻译： 用于治疗神经病变的方法包括以一种剂量向患有神经病变的患者给药多于5和小于18mg的氨基吡啶。 将氨基吡啶配制成立即释放制剂。 每天提供至少两个这样的剂量以产生足以驱动氨基吡啶穿过血液 - 神经屏障的尖峰血清血浆水平的氨基吡啶。

公开(公告)号：US06503931B1

公开(公告)日：2003-01-07

申请号：US09913082

申请日：2001-08-09

申请人： Jay M. Meythaler

发明人： Jay M. Meythaler

IPC分类号： A61K3144

CPC分类号： A61K31/4409 ,  A61K31/44

摘要： The present invention provides methods of using aminopyridine compounds to treat peripheral nervous system demyelinating diseases including Guillain-Barre Syndrome, diabetes mellitus, and hereditary sensory-motor neuropathies.

摘要翻译： 本发明提供了使用氨基吡啶化合物治疗包括格林巴利综合征，糖尿病和遗传性感觉运动神经病变的外周神经系统脱髓鞘疾病的方法。

公开(公告)号：US08513281B1

公开(公告)日：2013-08-20

申请号：US10049327

申请日：2000-08-10

申请人： Jay M. Meythaler ,  Jean Peduzzi

发明人： Jay M. Meythaler ,  Jean Peduzzi

IPC分类号： A61K31/495 ,  A61P3/10 ,  A61P3/06 ,  A61P27/02

CPC分类号： A61K31/60 ,  A61K31/609 ,  A61K38/17 ,  A61K45/06 ,  A61K2300/00

摘要： A method for treating a patient/subject having neuronal injury, pain, neurotrauma and/or traumatic brain injury, such as diffuse axonal injury, which includes intrathecally and/or intraventricularly administering to the subject a therapeutically effective amount of a non-steroidal anti-inflammatory drug and/or a naturally occurring omega conotoxin, functional fragment thereof, a pharmacologically acceptable salt, ester, amide, or prodrug thereof.

摘要翻译： 治疗患有神经元损伤，疼痛，神经损伤和/或创伤性脑损伤（例如弥漫性轴索损伤）的患者/受试者的方法，其包括鞘内和/或心室内施用治疗有效量的非甾体抗炎药物， 炎性药物和​​/或天然存在的ω-芋螺毒素，其功能片段，其药理学上可接受的盐，酯，酰胺或前药。

公开(公告)号：US07354954B1

公开(公告)日：2008-04-08

申请号：US10049328

申请日：2000-08-10

申请人： Jay M. Meythaler ,  Jean Peduzzi

发明人： Jay M. Meythaler ,  Jean Peduzzi

IPC分类号： A61K31/197

CPC分类号： A61K31/197

摘要： According to the subject invention, there is disclosed a method for treating a patient/subject having a spastic disorder, a convulsive disorder, pain or epilepsy which includes administering to the subject having any one of these conditions a therapeutically effective amount of the compound gamma-aminobutyramide, analogs, substituted forms, derivatives, the pharmaceutically acceptable salts, esters, amides, and prodrugs thereof, or compounds which yield gamma-aminobutyramide as an intermediate, a metabolite, or a by-product.

摘要翻译： 根据本发明，公开了一种用于治疗患有痉挛性障碍，惊厥性障碍，疼痛或癫痫的患者/受试者的方法，其包括向患者施用具有这些病症中的任何一种的治疗有效量的化合物γ- 氨基丁酰胺，类似物，取代形式，衍生物，其药学上可接受的盐，酯，酰胺和前药，或产生γ-氨基丁酰胺作为中间体，代谢物或副产物的化合物。

公开(公告)号：US20100210604A1

公开(公告)日：2010-08-19

申请号：US12664507

申请日：2008-06-13

申请人： Jay M. Meythaler

发明人： Jay M. Meythaler

IPC分类号： A61K31/616 ,  A61K31/60 ,  A61K31/5383 ,  A61K31/445 ,  A61K31/426 ,  A61K31/4375 ,  A61K31/4709 ,  A61K31/4418 ,  A61K31/546 ,  A61K31/485 ,  A61P25/00 ,  A61P29/00

CPC分类号： A61K47/02 ,  A61K9/0085

摘要： A formulation is provided that includes a volume of an aqueous multivalent physiological ion solution compatible with cerebrospinal fluid containing at least one divalent cation of magnesium or calcium, and at least one anion of carbonate or phosphate, and having a pH between 6.5 and 8.0. A zwitterionic therapeutic agent other than baclofen is dissolved the solution to achieve higher concentration or ease of solution and/or storage relative to therapeutic saline solutions of the same agent. A process of delivering a zwitterionic therapeutic agent into a subject is provided that includes dissolving a therapeutic amount of the zwitterionic therapeutic agent in a volume of artificial cerebrospinal fluid to form a stable formulation. The solution is then administered to the subject using an intrathecal pump.

摘要翻译： 提供了一种制剂，其包括与含有至少一种镁或钙的二价阳离子的脑脊液和至少一种碳酸盐或磷酸盐的阴离子并且具有6.5至8.0之间的pH的水性多价生理离子溶液的体积。 除了巴氯芬之外的两性离子治疗剂溶解溶液以实现相对于相同试剂的治疗盐水溶液的更高浓度或易于溶解和/或储存。 提供将两性离子治疗剂递送到受试者的过程，其包括将治疗量的两性离子治疗剂溶解在一定体积的人造脑脊液中以形成稳定的制剂。 然后使用鞘内注射泵将该溶液施用于受试者。

公开(公告)号：US06901933B2

公开(公告)日：2005-06-07

申请号：US10429356

申请日：2003-05-05

申请人： Jay M. Meythaler ,  Jean D. Peduzzi-Nelson ,  Evangelos Eleftheriou

发明人： Jay M. Meythaler ,  Jean D. Peduzzi-Nelson ,  Evangelos Eleftheriou

IPC分类号： G09B23/28 ,  A61B19/00 ,  A01K1/01

CPC分类号： G09B23/286

摘要： This invention is an apparatus for simulating human traumatic injury in an animal, said apparatus comprising a support having an aperture having end walls and side walls disposed therein; a sliding element slidingly engaged with said side walls of said aperture, said sliding element having a retainer disposed thereon for receiving an animal holder having a hinged first end therein; and a crank arm operatively connected to both said sliding element, and an actuator mechanism. The apparatus allows animal head motion simulative of hyperflexural trauma associated with actual injuries.

摘要翻译： 本发明是一种用于模拟动物中的人类创伤性损伤的装置，所述装置包括具有其中设置有端壁和侧壁的孔的支撑件; 与所述孔的所述侧壁滑动地接合的滑动元件，所述滑动元件具有设置在其上的保持器，用于接收其中具有铰接的第一端的动物保持器; 以及可操作地连接到所述滑动元件和致动器机构的曲柄臂。 该装置允许模拟与实际伤害相关的超声创伤的动物头部运动。