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1.发明授权Compounds, compositions and methods for medical imaging of Parkinson's disease 有权用于帕金森病医学成像的化合物，组合物和方法公开(公告)号：US08329142B2
公开(公告)日：2012-12-11
申请号：US12178281
申请日：2008-07-23
CPC分类号： A61K49/10 , A61K51/0406 , G01N33/6896 , G01N2800/2835
摘要： Compounds, compositions and methods for the detection and diagnosis of Parkinson's disease. Derivative lycerophosphocholine (GPC) compounds are used as a detection and diagnostic aid to measure progression of Parkinson's disease by detecting GPC binding to α-synuclein. Derivative CPG compounds including non-radioactive, paramagnetic, and radioactive derivatives of GPC are presented. These compounds possess similar binding properties to original GPC molecules and are useful in medical magnetic resonance imaging (MRI) and/or positron emission tomography (PET) applications. By employing these radiological techniques in conjunction with the compositions of the present invention, the detection, diagnosis and assessment of the progression of Parkinson's disease may be achieved.
摘要翻译： 用于检测和诊断帕金森病的化合物，组合物和方法。 衍生的裂解磷酸胆碱（GPC）化合物用作检测和诊断辅助，通过检测GPC与α-突触核蛋白的结合来测量帕金森病的进展。 提出了包括GPC的非放射性，顺磁性和放射性衍生物的衍生CPG化合物。 这些化合物具有与原始GPC分子相似的结合特性，并且可用于医学磁共振成像（MRI）和/或正电子发射断层摄影（PET）应用。 通过结合本发明的组合使用这些放射技术，可以实现帕金森病进展的检测，诊断和评估。
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2.发明申请COMPOUNDS, COMPOSITIONS AND METHODS FOR PRODUCING ANTIOXIDANTS FROM CARNITINE 有权化合物，组合物和方法从CARNITINE生产抗氧化剂公开(公告)号：US20090069423A1
公开(公告)日：2009-03-12
申请号：US12183609
申请日：2008-07-31
IPC分类号： A61K31/225 , C12P13/00 , A61P25/28
CPC分类号： A61K31/22 , A23L33/175 , A23P20/105 , A23V2002/00 , A61K31/225 , A61K36/28 , A23V2250/0612 , A23V2200/322 , A23V2200/02
摘要： Carnitines are nutraceuticals with indications in treating a variety of mental health disorders. A metabolomics-guided bioprocess method is presented to produce longer chain fatty acid esters of carnitines such as polyunsaturated fatty acid esters including eicosapentaenoyl-L-carnitine and/or docosahexaenyl-L-carnitine in germinating plant seeds. The resulting products from the plant seeds are used as a natural nutritional source of powerful human antioxidants.
摘要翻译： 肉碱是具有治疗各种精神健康障碍的营养药物。 提出代谢组学指导的生物过程方法，用于在发芽植物种子中产生肉碱的长链脂肪酸酯，如多不饱和脂肪酸酯，包括二十碳五烯酰基-L-肉碱和/或二十二碳六烯基-L-肉毒碱。 来自植物种子的所得产品被用作强大的人类抗氧化剂的天然营养来源。
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3.发明授权Compounds, compositions and methods for medical imaging of neuropsychiatric disorders 有权用于神经精神障碍的医学成像的化合物，组合物和方法公开(公告)号：US07815894B2
公开(公告)日：2010-10-19
申请号：US10854894
申请日：2004-05-27
CPC分类号： G01N33/6896 , A61K49/10 , A61K51/0406 , G01N2800/2821
摘要： Compounds, compositions and methods for the diagnosis of Alzheimer's disease. Synthesized Glycerophosphocholine (GPC) may be used as a diagnostic aid to measure progression of Alzheimer's disease. GPC is a membrane phospholipid metabolite that is capable of binding specifically to the β-turn of beta amyloid (Aβ) peptide. Compounds including non-radioactive, paramagnetic, and radioactive derivatives of GPC are presented. These compounds possess similar binding properties to original GPC molecules and are useful in medical magnetic resonance imaging and/or positron emission tomography applications. By employing these radiological techniques in conjunction with the compositions of the present invention, the diagnosis and assessment of the progression of Alzheimer's disease may be achieved.
摘要翻译： 用于诊断阿尔茨海默病的化合物，组合物和方法。 合成的甘油磷酸胆碱（GPC）可用作诊断阿尔茨海默氏病进展的诊断辅助。 GPC是一种能够特异性结合β-淀粉样蛋白（A＆bgr））肽的膜磷脂代谢产物。 提出了包括GPC的非放射性，顺磁性和放射性衍生物的化合物。 这些化合物具有与原始GPC分子相似的结合特性，并且可用于医学磁共振成像和/或正电子发射断层摄影应用。 通过结合本发明的组合物使用这些放射技术，可以实现阿尔茨海默病进展的诊断和评估。
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4.发明授权Compounds, compositions and methods for producing antioxidants from carnitine 有权用于从肉碱生产抗氧化剂的化合物，组合物和方法公开(公告)号：US07632662B2
公开(公告)日：2009-12-15
申请号：US12183609
申请日：2008-07-31
IPC分类号： C12P21/02
CPC分类号： A61K31/22 , A23L33/175 , A23P20/105 , A23V2002/00 , A61K31/225 , A61K36/28 , A23V2250/0612 , A23V2200/322 , A23V2200/02
摘要： Carnitines are nutraceuticals with indications in treating a variety of mental health disorders. A metabolomics-guided bioprocess method is presented to produce longer chain fatty acid esters of carnitines such as polyunsaturated fatty acid esters including eicosapentaenoyl-L-carnitine and/or docosahexaenyl-L-carnitine in germinating plant seeds. The resulting products from the plant seeds are used as a natural nutritional source of powerful human antioxidants.
摘要翻译： 肉碱是具有治疗各种精神健康障碍的营养药物。 提出代谢组学指导的生物过程方法，用于在发芽植物种子中产生肉碱的长链脂肪酸酯，如多不饱和脂肪酸酯，包括二十碳五烯酰基-L-肉碱和/或二十二碳六烯基-L-肉毒碱。 来自植物种子的所得产品被用作强大的人类抗氧化剂的天然营养来源。
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5.发明申请COMPOUNDS, COMPOSITIONS AND METHODS FOR MEDICAL IMAGING OF PARKINSON'S DISEASE 有权化合物，组合物和方法用于帕金森病的医学成像公开(公告)号：US20080292557A1
公开(公告)日：2008-11-27
申请号：US12178281
申请日：2008-07-23
CPC分类号： A61K49/10 , A61K51/0406 , G01N33/6896 , G01N2800/2835
摘要： Compounds, compositions and methods for the detection and diagnosis of Parkinson's disease. Derivative lycerophosphocholine (GPC) compounds are used as a detection and diagnostic aid to measure progression of Parkinson's disease by detecting GPC binding to α-synuclein. Derivative CPG compounds including non-radioactive, paramagnetic, and radioactive derivatives of GPC are presented. These compounds possess similar binding properties to original GPC molecules and are useful in medical magnetic resonance imaging (MRI) and/or positron emission tomography (PET) applications. By employing these radiological techniques in conjunction with the compositions of the present invention, the detection, diagnosis and assessment of the progression of Parkinson's disease may be achieved.
摘要翻译： 用于检测和诊断帕金森病的化合物，组合物和方法。 衍生的裂解磷酸胆碱（GPC）化合物用作检测和诊断辅助，通过检测GPC结合α-突触核蛋白来测量帕金森病的进展。 提出了包括GPC的非放射性，顺磁性和放射性衍生物的衍生CPG化合物。 这些化合物具有与原始GPC分子相似的结合特性，并且可用于医学磁共振成像（MRI）和/或正电子发射断层摄影（PET）应用。 通过结合本发明的组合使用这些放射技术，可以实现帕金森病进展的检测，诊断和评估。
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公开(公告)号：US20100156634A1
公开(公告)日：2010-06-24
申请号：US12653662
申请日：2009-12-16
CPC分类号： G01R33/072 , G01R33/091 , G01T1/00
摘要： A table top mounted apparatus and method for detecting contraband, such as paper currency, within a container, where the contraband has a ferromagnetic component. The apparatus includes a DC magnetic field source for inducing a de-magnetization field in any ferromagnetic contraband that may be present within a container, and magnetic sensors for detecting certain characteristic patterns in the “de-mag” field induced by the DC magnetic field source. These certain characteristic field patterns are indicative of contraband arranged in commonly found arrangements of such types of contraband.
摘要翻译： 用于在容器内检测违禁品具有铁磁性成分的违禁品例如纸币的桌面安装装置和方法。 该装置包括用于在可能存在于容器内的任何铁磁性违禁品中引起去磁场的DC磁场源和用于检测由DC磁场源引起的“去磁场”场中的某些特征图案的磁传感器 。 这些特定的田野模式表示违禁品被排列成这种类型的违禁品的普遍发现的布置。
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公开(公告)号：US5931807A
公开(公告)日：1999-08-03
申请号：US843664
申请日：1997-04-10
CPC分类号： A61B18/1815 , A61B18/18 , A61M2202/08
摘要： A method and apparatus for heating fatty tissue to facilitate liposuction removal of fat and, by additional heating, to enable denaturing of the tissue structure. The apparatus uses microwave energy, applied by a cannula to the fatty tissue, as a means to facilitate fat removal. The microwave energy is delivered at a frequency range chosen to optimize energy coupling directly to the fatty tissue, while insuring the attenuation of the radiation level to a safe level in a relatively short distance. The cannula is provided with internal channels to simultaneously provide fluid and remove the mixture of fluid and fatty tissue. Since the microwave frequency is selected to insure direct coupling with the fat tissue, it is not necessary to introduce water to promote coupling, and if water is introduced for cooling or irrigation purposes, no salts need to be added to the water for purposes of microwave energy coupling.
摘要翻译： 一种用于加热脂肪组织以促进脂肪抽吸去除脂肪以及通过额外加热以使组织结构变性的方法和装置。 该装置使用通过插管施加到脂肪组织的微波能量作为促进脂肪去除的手段。 在选择的频率范围内递送微波能量以优化直接与脂肪组织的能量耦合，同时确保辐射水平的衰减在相对短的距离内达到安全水平。 插管设置有内部通道，以同时提供流体并除去流体和脂肪组织的混合物。 由于选择微波频率以确保与脂肪组织的直接耦合，因此不需要引入水来促进偶联，并且如果为了冷却或灌溉而引入水，则为了微波而不需要向水中加入盐 能量耦合。
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8.发明授权
公开(公告)号：US4875127A
公开(公告)日：1989-10-17
申请号：US178400
申请日：1988-04-06
申请人： Richard J. McClure
发明人： Richard J. McClure
CPC分类号： G11B15/62 , G11B15/602
摘要： In a magnetic tape transport where the tape is guided by means of conventional guides, the tape may wander at the surface of the magnetic transducer between limits set by the mechanical parameters of the guides, e.g. the distance between upper and lower flanges of the guides. The present invention teaches tilting the face of the transducer contacting the tape by an angle of 0.5.degree. such that a component of force is generated which slides the tape along the transducer surface. The edge of the tape is then constrained to ride against a wear resistant shoulder mounted on the transducer surface, resulting in the tape being "locked" into position in relation to the magnetic transducer tracks.
摘要翻译： 在磁带通过常规引导件引导的磁带传输中，磁带可以在导向器的机械参数设置的极限之外，在磁换能器的表面上漂移。 引导件的上法兰和下法兰之间的距离。 本发明教导了将接触带的换能器的表面倾斜0.5°的角度，使得产生沿着换能器表面滑动带的力分量。 然后限制带的边缘抵靠安装在换能器表面上的耐磨肩部，导致带相对于磁换能器轨道“锁定”到位。
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公开(公告)号：US4670800A
公开(公告)日：1987-06-02
申请号：US730138
申请日：1985-05-03
申请人： Richard J. McClure
发明人： Richard J. McClure
CPC分类号： G11B5/4893 , G11B15/602 , G11B5/584
摘要： Drawing on the observation that a signal which is magnetically recorded near the edge of a magnetic tape not only projects a magnetic field that is above (and below) the plane of the tape, but also projects a field that extends away from the edge thereof, the invention calls for (tracking-) control of relative head-to-tape positioning in response to the edge-projected field of a pre-recorded edge-positioned tracking control signal, whereby the tightness of such control is governed directly by the spacing loss equation.
摘要翻译： 考虑到在磁带边缘附近被磁记录的信号不仅投射在磁带的平面之上（或以下）的磁场，而且还突出了远离其边缘的场， 本发明响应于预先记录的边缘定位的跟踪控制信号的边缘投影场来要求（跟踪）控制相对的头对带定位，由此这种控制的紧密性直接由间隔损耗 方程。
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公开(公告)号：US4398229A
公开(公告)日：1983-08-09
申请号：US289845
申请日：1981-08-03
申请人： Richard J. McClure
发明人： Richard J. McClure
CPC分类号： G11B15/12 , G11B5/2452 , G11B5/4907
摘要： Apparatus squeezes together, on selective command, the poles of a core having a gap of a given physical gap length, thereby to place the poles under stress. Stress decreases the permeability of the pole material. Attendantly, in response to the application of stress, the effective gap of the core lengthens. Release of the applied stress restores the effective gap length to that corresponding to the physical gap length. To increase pole stress, the invention employs a piezoelectric element that is bonded to the core across its gap. Application of an electrical signal (of predetermined polarity) to the piezoelectric element causes the element to contract, thereby squeezing the poles together.
摘要翻译： 设备按选择性命令一起挤压具有给定物理间隙长度的间隙的芯的极点，从而将极点置于应力之下。 应力会降低极材料的渗透性。 随之而来的是，应对压力的应用，核心的有效差距越来越大。 释放施加的应力将有效间隙长度恢复到对应于物理间隙长度的有效间隙长度。 为了增加极应力，本发明采用压电元件，其通过其间隙与芯结合。 将电信号（预定极性）施加到压电元件使得元件收缩，从而将极点挤压在一起。
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