公开(公告)号：US4168377A

公开(公告)日：1979-09-18

申请号：US459712

申请日：1974-04-10

申请人： Jean Choay ,  Jean Goulay ,  Jean-Louis Amiot

发明人： Jean Choay ,  Jean Goulay ,  Jean-Louis Amiot

IPC分类号： C08B37/10

CPC分类号： C08B37/0075 ,  Y10S514/822

摘要： Mixed or simple heparin salt having a reduced amount of a selected metal ion alone or with another metal ion in a mixed heparin. A heparin salt having a reduced sodium content being essentially sodium free and having a selectively high calcium or other selected salt content. A process for making these heparin salts by reaction with the selected metal salt, including, optionally, dialysis or precipitation. A typical heparin salt is a calcium heparin essentially free of sodium (like containing less than about 1% by weight of sodium), or mixed calcium-sodium heparin with a limited, predetermined content of sodium. Drug compositions containing these heparin salts and a pharmaceutical carrier. The drugs made from these heparin salts are useful as anti-coagulants.

摘要翻译： 混合或简单的肝素盐，其中单独选择的金属离子量与混合肝素中的另一种金属离子的量减少。 具有降低的钠含量的肝素盐基本上不含钠且具有选择性高钙或其它选择的盐含量。 通过与选择的金属盐反应制备这些肝素盐的方法，包括任选的透析或沉淀。 典型的肝素盐是基本上不含钠的钙肝素（如含有少于约1重量％的钠）或具有有限的预定含量的钠的混合的钙 - 钠肝素。 含有这些肝素盐和药物载体的药物组合物。 由这些肝素盐制成的药物可用作抗凝剂。