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    Mucopolysaccharide composition having a regulatory action on coagulation, medicament containing same and process of preparation
    6.
    发明授权
    Mucopolysaccharide composition having a regulatory action on coagulation, medicament containing same and process of preparation 失效
    具有凝血调节作用的粘多糖组合物，含有其的药物和制备方法

    公开(公告)号：US4692435A

    公开(公告)日：1987-09-08

    申请号：US726178

    申请日：1985-04-23

    申请人： Jean-Claude Lormeau ,  Jean Goulay ,  Jean Choay

    发明人： Jean-Claude Lormeau ,  Jean Goulay ,  Jean Choay

    IPC分类号： C08B37/10 ,  G01N33/86 ,  A61K31/725

    CPC分类号： A61K31/715 ,  C08B37/0075 ,  G01N33/86 ,  G01N2333/8128 ,  G01N2400/40

    摘要： The invention pertains to a mucopolysaccharide fraction obtainable from heparin or from fractions including heparinic constituents of molecular weights from 2000 to 50,000, which has a Yin-Wessler titer which is high relative to the USP titer. It contains components whose molecular weights are less than 10,000, particularly oligosaccharides in the area of 2000-3000, comprising from 8 to 12, notably 10 monosaccharide units, among which glucosamine units whose primary positions are sulphated. The last mentioned oligosaccharides include one N-acetyl-glucosamine unit per two units of 2-O-sulphate iduronic acid and per two N-sulphate-glucosamine units, the other saccharide units being of a different nature and including distinct substituents.

    摘要翻译： 本发明涉及从肝素或包含分子量为2000-5000的肝素成分的馏分获得的粘多糖级分，其相对于USP滴度高，具有殷威士滴定度。 它含有分子量小于10,000的成分，特别是2000-3000区域的低聚糖，其中8至12个，特别是10个单糖单元，其中主要位置硫酸化的葡糖胺单元。 最后提及的寡糖包括每两单位的2-O-硫酸艾杜糖醛酸和每两个N-硫酸 - 葡糖胺单元的一个N-乙酰基 - 葡糖胺单元，其它糖单元具有不同的性质并且包括不同的取代基。

    Oligomers of compounds of the muramyl-peptide type and medicaments containing them
    7.
    发明授权
    Oligomers of compounds of the muramyl-peptide type and medicaments containing them 失效
    胞壁酰胺类化合物的低聚物和含有它们的药物

    公开(公告)号：US4461761A

    公开(公告)日：1984-07-24

    申请号：US410727

    申请日：1982-08-23

    申请人： Pierre Lefrancier ,  Monique Parant ,  Francoise Audibert ,  Edgar Sache ,  Louis Chedid ,  Jean Choay ,  Edgar Lederer

    发明人： Pierre Lefrancier ,  Monique Parant ,  Francoise Audibert ,  Edgar Sache ,  Louis Chedid ,  Jean Choay ,  Edgar Lederer

    IPC分类号： A61K39/39 ,  C07K9/00 ,  A61K37/00 ,  C07C103/52

    CPC分类号： C07K9/005

    摘要： The novel products are water-soluble oligomers, free of N-acetyl-glucosamine units, and of which the monomer elements include a group derived from muramic acid on which is fixed a chain of the peptide type including at least two aminoacyl residues, the first being selected from among: L-alanyl, L-arginyl, L-asparagyl, L-histidyl, L-hydroxyprolyl, L-isoleucyl, L-leucyl, L-methionyl, L-phenylalanyl, L-prolyl, L-seryl, L-threonyl, L-tryptophanyl, L-valyl, and the second aminoacyl is D-glutamyl or D-isoglutaminyl. They are useful for their immunoregulator properties and for the preparation of pharmaceutical compositions.

    摘要翻译： 新产品是不含N-乙酰葡糖胺单元的水溶性低聚物，其单体元素包括衍生自其中固定有至少两个氨酰基残基的肽类链的基团，第一 选自：L-丙氨酰，L-精氨酰，L-天冬酰胺基，L-组氨酰基，L-羟基脯氨酰，L-异亮氨酰，L-亮氨酰，L-甲硫氨酰，L-苯丙氨酰，L-脯氨酰，L-丝氨酰，L - 苏氨酰基，L-色氨酸，L-缬氨酰，第二氨酰基是D-谷氨酰或D-异谷氨酰胺基。 它们可用于其免疫调节剂性质和药物组合物的制备。

    Muramyl peptide substituted on a peptide nitrogen and medicaments containing the same
    8.
    发明授权
    Muramyl peptide substituted on a peptide nitrogen and medicaments containing the same 失效
    在肽氮上取代的Muramyl肽和含有它的药物

    公开(公告)号：US4427659A

    公开(公告)日：1984-01-24

    申请号：US337503

    申请日：1982-01-06

    申请人： Pierre Le Francier ,  Francoise Audibert ,  Jean Choay ,  Louis Chedid ,  Edgar Lederer

    发明人： Pierre Le Francier ,  Francoise Audibert ,  Jean Choay ,  Louis Chedid ,  Edgar Lederer

    IPC分类号： A61K38/00 ,  A61K39/39 ,  A61P37/04 ,  C07K9/00 ,  A61K37/00 ,  C07C103/52

    CPC分类号： C07K9/005

    摘要： The invention relates to novel compounds of the muramyl-peptide type and to their uses. The muramyl-peptides according to the invention comprise at least two aminoacyl residues in the peptide chain, the second of these aminoacyl residues being D-glutamyl, and they are characterized in that the nitrogen of the first amino-acyl, and forming part of the pepetide linkage connecting the muramyl group to the peptide residue, is substituted by an alkyl group. These compounds are useful notably for the preparation of pharmaceutical compositions, in particular by reason of their regulatory properties on the immune responses of the organism.

    摘要翻译： 本发明涉及胞壁酰肽类型的新化合物及其用途。 根据本发明的胞壁酰肽多肽在肽链中包含至少两个氨酰基残基，其中第二个氨酰基残基是D-谷氨酰基，其特征在于第一氨基酰基的氮，并形成 连接胞壁酰胺基与肽残基的肽键连接被烷基取代。 这些化合物特别用于制备药物组合物，特别是由于其对生物体的免疫应答的调节性质。

    1-Quinolinyl-pyrazolidine derivatives
    10.
    发明授权
    1-Quinolinyl-pyrazolidine derivatives 失效
    1-喹啉基 - 吡唑烷衍生物

    公开(公告)号：US3996231A

    公开(公告)日：1976-12-07

    申请号：US487536

    申请日：1974-07-11

    申请人： Camille Georges Wermuth ,  Jean Choay

    发明人： Camille Georges Wermuth ,  Jean Choay

    IPC分类号： C07D215/42 ,  A61K31/47 ,  C07D231/20 ,  C07D401/04

    CPC分类号： C07D401/04 ,  A61K31/47

    摘要： The derivatives have the general formula ##STR1## in which X is a hydrogen atom or a methyl, phenyl or benzyl group; Y is a carbon chain comprising 2 to 6 carbon atoms, saturated or unsaturated, unsubstituted or substituted by alkyl, alkoxyl or halogen groups, said chain including if necessary, instead and in place of an aliphatic link, a carbonyl or alcohol group; Z is constituted by a hydrogen atom or defines at least an alkyl, alkoxyl or halogen group fixed at any position of the quinolinyl nucleus. They have high anti-inflammatory and analgesic activities.

    摘要翻译： 衍生物具有其中X为氢原子或甲基，苯基或苄基的通式; Y是含有2-6个碳原子的碳原子，饱和或不饱和的，未被取代的或被烷基，烷氧基或卤素基团取代，所述链包括必要时代替脂族基，羰基或醇基; Z由氢原子构成或至少限定在喹啉基核的任何位置固定的烷基，烷氧基或卤素基团。 他们具有高消炎止痛活性。