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    1H-INDOL-1-YL-UREA COMPOUNDS
    1.
    发明申请
    1H-INDOL-1-YL-UREA COMPOUNDS 审中-公开
    1H-INDOL-1-YL-UREA化合物

    公开(公告)号：US20090176794A1

    公开(公告)日：2009-07-09

    申请号：US12317904

    申请日：2008-12-30

    申请人： Jean-Daniel Brion ,  Abdallah Deyine ,  Alain Le Ridant ,  Catherine Harpey

    发明人： Jean-Daniel Brion ,  Abdallah Deyine ,  Alain Le Ridant ,  Catherine Harpey

    IPC分类号： A61K31/4439 ,  C07D401/02 ,  C07D403/02 ,  A61K31/454 ,  A61K31/506 ,  A61K31/501 ,  A61P25/28 ,  A61P25/16 ,  A61P25/22 ,  A61P25/24

    CPC分类号： C07D401/12 ,  C07D209/08 ,  C07D403/12

    摘要： Compounds of formula (I): wherein:R1 and R2, which may be the same or different, represent a hydrogen atom or a linear or branched (C1-C6)alkyl group,R3 represents a hydrogen or halogen atom, a linear or branched (C1-C6)alkyl group, or a linear or branched (C1-C6)alkoxy group,Het represents a pyridyl, pyrimidinyl or piperidyl group, which are optionally substituted by one or more groups selected from halogen, linear or branched (C1-C6)alkyl and linear or branched (C1-C6)alkoxy,—represents a single bond or a double bond,their enantiomers and diastereoisomers, and also addition salts thereof with a pharmaceutically acceptable acid or base.Medicinal products containing the same which are useful in the treatment of depression, anxiety, disorders of memory in the course of aging and/or neurodegenerative diseases, and in the palliative treatment of Parkinson's disease, and for adaptation to stress.

    摘要翻译： 式（I）化合物：其中：R1和R2可以相同或不同，表示氢原子或直链或支链（C1-C6）烷基，R3表示氢或卤素原子，直链或支链 （C 1 -C 6）烷基，或直链或支链（C 1 -C 6）烷氧基，Het表示吡啶基，嘧啶基或哌啶基，其任选被一个或多个选自以下的基团取代：卤素，直链或支链（C1- C6）烷基和直链或支链（C1-C6）烷氧基， - 表示单键或双键，它们的对映体和非对映异构体，以及其与药学上可接受的酸或碱的加成盐。 含有它们的药用产品，其可用于治疗抑郁症，焦虑症，老化和/或神经变性疾病过程中的记忆障碍，以及帕金森病的姑息治疗以及适应压力。

    TRIAZABENZO (A)NAPHTHO(2,1,8-CDE) AZULENE COMPOUNDS.
    3.
    发明申请
    TRIAZABENZO (A)NAPHTHO(2,1,8-CDE) AZULENE COMPOUNDS. 审中-公开
    三氮杂萘（A）萘（2,1,8-CDE）亚苄基化合物。

    公开(公告)号：US20100105666A1

    公开(公告)日：2010-04-29

    申请号：US12448627

    申请日：2008-01-04

    申请人： Jean-Daniel Brion ,  Maud Hervet ,  Anne Moreau ,  Zafiarisoa Dolor Renko ,  Alain Le Ridant ,  Catherine Harpey

    发明人： Jean-Daniel Brion ,  Maud Hervet ,  Anne Moreau ,  Zafiarisoa Dolor Renko ,  Alain Le Ridant ,  Catherine Harpey

    IPC分类号： A61K31/551 ,  C07D487/22 ,  A61P25/22 ,  A61P25/16 ,  A61P25/24

    CPC分类号： C07D471/22

    摘要： Compounds of formula (I): wherein: R1 represents hydrogen, (C1-C6)alkyl, (C1-C6)aminoalkyl or (C1-C6)hydroxyalkyl, R2 represents hydrogen, or R1 and R2, together with the carbon atoms carrying them, form a carbon-carbon bond, R3 represents hydrogen, R4 represents hydrogen, methyl or (C3-C6)alkyl, (C1-C6)aminoalkyl, (C1-C6)hydroxyalkyl, aryl-(C1-C6)alkyl or heterocycloalkyl-(C1-C6)alkyl, or R3 and R4 together with the carbon atoms carrying them, form a carbon-carbon bond, R5, R6, R7 and R8 represent hydrogen, or a pair of geminal substituents (R5 and R6 and/or R7 and R8) form an oxo, thioxo or imino group, R9 represents hydrogen, halogen, (C1-C6)alkyl, (C1-C6)alkoxy, hydroxy, cyano, nitro, (C1-C6)polyhaloalkyl or optionally substituted amino, R10 and R11 represent hydrogen, halogen, (C1-C6)alkyl, (C1-C6)alkoxy, hydroxy, cyano, nitro, (C1-C6)polyhaloalkyl or optionally substituted amino, n represents an integer between 0 and 4 inclusive, m represents an integer between 0 and 2 inclusive, p represents an integer between 0 and 3 inclusive, X represents a group NR12, R12 represents hydrogen, (C1-C6)alkyl, (C2-C6)alkenyl, aryl-(C1-C6)alkyl or (C1-C6)polyhaloalkyl, their enantiomers, diastereoisomers and N-oxides, and also addition salts thereof with a pharmaceutically acceptable acid or base.

    摘要翻译： 式（I）化合物：其中：R1表示氢，（C1-C6）烷基，（C1-C6）氨基烷基或（C1-C6）羟基烷基，R2表示氢，或R1和R2以及携带它们的碳原子 （C 1 -C 6）烷基，（C 1 -C 6）羟基烷基，芳基 - （C 1 -C 6）烷基或杂环烷基 - （C 1 -C 6） （C1-C6）烷基或R3和R4与携带它们的碳原子一起形成碳 - 碳键，R5，R6，R7和R8表示氢或一对偕取代基（R5和R6和/或R7 卤素，（C1-C6）烷基，（C1-C6）烷氧基，羟基，氰基，硝基，（C1-C6）多卤代烷基或任意取代的氨基，R10 并且R 11表示氢，卤素，（C 1 -C 6）烷基，（C 1 -C 6）烷氧基，羟基，氰基，硝基，（C 1 -C 6）多卤代烷基或任选取代的氨基，n表示0至4的整数， 0和2之间的整数，包括0和2， p表示0〜3的整数，X表示NR12，R12表示氢，（C1-C6）烷基，（C2-C6）烯基，芳基 - （C1-C6）烷基或（C1-C6）多卤代烷基， 它们的对映异构体，非对映异构体和N-氧化物，以及其与药学上可接受的酸或碱的加成盐。

    1H-Indole-Pyridinecarboxamide and 1H-Indole-Piperidinecarboxamide Compounds
    4.
    发明申请
    1H-Indole-Pyridinecarboxamide and 1H-Indole-Piperidinecarboxamide Compounds 审中-公开
    1H-吲哚 - 吡啶甲酰胺和1H-吲哚 - 哌啶甲酰胺化合物

    公开(公告)号：US20090258883A1

    公开(公告)日：2009-10-15

    申请号：US11988424

    申请日：2006-07-06

    申请人： Jean-Daniel Brion ,  Fabrice Bintein ,  Rodolphe Razet ,  Patrick Razon ,  Zafiarisoa Dolor Renko ,  Eric Levoirier ,  Jean-Francois Pujol ,  Dinah Weissmann ,  Alain Le Ridant ,  Catherine Harpey

    发明人： Jean-Daniel Brion ,  Fabrice Bintein ,  Rodolphe Razet ,  Patrick Razon ,  Zafiarisoa Dolor Renko ,  Eric Levoirier ,  Jean-Francois Pujol ,  Dinah Weissmann ,  Alain Le Ridant ,  Catherine Harpey

    IPC分类号： A61K31/496 ,  C07D401/12 ,  A61K31/454 ,  A61P25/22 ,  A61P25/16 ,  A61P25/24 ,  A61P25/28 ,  A61K31/4439 ,  C07D401/14

    CPC分类号： C07D401/12

    摘要： Compounds of formula (I): wherein: A represents a divalent radical: wherein: Z represents an oxygen atom or a sulphur atom, R6 represents a hydrogen atom, an alkyl, alkenyl, arylalkyl or polyhaloalkyl group or a substituted, linear or branched alkyl chain, represents a single bond or a double bond, R1, R2, R3 and R4 represent a hydrogen or halogen atom, an alkyl, alkoxy, hydroxy, cyano, nitro, polyhaloalkyl or optionally substituted amino group, or a linear or branched alkyl chain substituted by one or more groups, R5 represents a hydrogen atom or an alkyl, aminoalkyl or hydroxyalkyl group, X and Y represent a hydrogen atom or an alkyl group, Ra, Rb, Rc and Rd represent a hydrogen or halogen atom, an alkyl, hydroxy, alkoxy, cyano, nitro, polyhaloalkyl, optionally substituted amino group, or a substituted, linear or branched alkyl chain, Re represents a hydrogen atom or an alkyl, arylalkyl or alkenyl group or a substituted, linear or branched alkyl chain, their enantiomers, diastereoisomers, and N-oxides, and also addition salts thereof with a pharmaceutically acceptable acid or base.

    摘要翻译： 式（I）化合物：其中：A表示二价基团：其中：Z表示氧原子或硫原子，R6表示氢原子，烷基，烯基，芳基烷基或多卤代烷基或取代的直链或支链烷基 链接，表示单键或双键，R 1，R 2，R 3和R 4表示氢或卤素原子，烷基，烷氧基，羟基，氰基，硝基，多卤代烷基或任选取代的氨基，或直链或支链烷基链 被一个或多个基团取代，R 5表示氢原子或烷基，氨基烷基或羟烷基，X和Y表示氢原子或烷基，R a，R b，R c和R d表示氢或卤素原子，烷基， 羟基，烷氧基，氰基，硝基，多卤代烷基，任选取代的氨基或取代的直链或支链烷基链， 表示氢原子或烷基，芳基烷基或烯基或取代的直链或支链烷基链，它们的对映异构体，非对映异构体和N-氧化物，以及其与药学上可接受的酸或碱的加成盐。

    3-(4-oxo-4H-chromen-2-yl)-(1H)-quinolin-4-one derivatives, method for preparing same and pharmaceutical compositions containing same
    5.
    发明授权
    3-(4-oxo-4H-chromen-2-yl)-(1H)-quinolin-4-one derivatives, method for preparing same and pharmaceutical compositions containing same 失效
    3-（4-氧代-4H-色烯-2-基） - （1H） - 喹啉-4-酮衍生物，其制备方法和含有它们的药物组合物

    公开(公告)号：US07339061B2

    公开(公告)日：2008-03-04

    申请号：US10519208

    申请日：2003-06-18

    申请人： Jean-Daniel Brion ,  Lucien Israel ,  Alain Le Ridant ,  Catherine Harpey ,  Cherif Rabhi ,  El Bachir Kaloun

    发明人： Jean-Daniel Brion ,  Lucien Israel ,  Alain Le Ridant ,  Catherine Harpey ,  Cherif Rabhi ,  El Bachir Kaloun

    IPC分类号： C07D215/38

    CPC分类号： C07D405/04 ,  C07D405/14

    摘要： Compound of formula (I): wherein: R1, R2, R3, R4, R6, R8, R9 and R10, which may be the same or different, each represent a group selected from hydrogen, hydroxy, alkoxy, alkyl, arylalkoxy, alkoxycarbonylalkoxy and OR′ wherein R′ represents an ionised or ionisable group, R5 represents a group selected from alkyl, aryl and heteroaryl, R7 represents a group selected from hydrogen, hydroxy, alkoxy, alkyl and cycloalkyl, or R7 represents a nitrogen-containing or oxygen-containing heterocycle, its optical isomers, hydrates and solvates thereof and addition salts thereof, with a pharmaceutically acceptable acid or base. Medicinal products containing the same which are useful as anti-cancer agents.

    摘要翻译： 式（I）化合物：其中：R 1，R 2，R 3，R 4，R R 6，R 8，R 9和R 10可以相同或不同，各自表示 选自氢，羟基，烷氧基，烷基，芳基烷氧基，烷氧基羰基烷氧基和OR'的基团，其中R'表示电离或可离子基团，R 5表示选自烷基，芳基和杂芳基的基团，R SUB > 7表示选自氢，羟基，烷氧基，烷基和环烷基的基团，或R 7表示含氮或含氧杂环，其光学异构体，水合物和溶剂合物 和其加成盐与药学上可接受的酸或碱。 含有该药物的药物可用作抗癌剂。