公开(公告)号：US20070099924A1

公开(公告)日：2007-05-03

申请号：US10596514

申请日：2004-12-20

申请人： Jean-Francois Bonfanti ,  Koenraad Jozef Lodewijk Andries ,  Jerome Michel Claude Fortin ,  Philippe Muller ,  Frederic Marc Maurice Doublet ,  Chirstophe Meyer ,  Rudy Edmond Willebrods ,  Tom Valerius Josepha Gevers ,  Philip Maria Martha Bern Timmerman

发明人： Jean-Francois Bonfanti ,  Koenraad Jozef Lodewijk Andries ,  Jerome Michel Claude Fortin ,  Philippe Muller ,  Frederic Marc Maurice Doublet ,  Chirstophe Meyer ,  Rudy Edmond Willebrods ,  Tom Valerius Josepha Gevers ,  Philip Maria Martha Bern Timmerman

IPC分类号： A61K31/498 ,  A61K31/497 ,  A61K31/4709 ,  A61K31/4439 ,  A61K31/4184 ,  C07D403/02

CPC分类号： C07D401/06 ,  C07D235/20 ,  C07D235/30 ,  C07D401/12 ,  C07D401/14 ,  C07D403/02 ,  C07D405/14 ,  C07D471/04 ,  C07F9/65583

摘要： Aminobenzimidazoles and benzimidazoles having inhibitory activity on RSV replication and having the formula the prodrugs, N-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms thereof, wherein G is a direct bond or C1-10alkanediyl optionally substituted with one or more hydroxy, C1-6alkyloxy, Ar1C1-6alkyloxy, C1-6alkylthio, Ar1C1-6alkylthio, HO(—CH2—CH2—O)n—, C1-6alkyloxy(—CH2—CH2—O)n— or Ar1C1-6alkyloxy(—CH2—CH2—O)n—; R1 is Ar1 or a monocyclic or bicyclic heterocycle; Q is hydrogen, amino or mono- or di(C1-4alkyl)amino; one of R2a and R3a is selected from halo, optionally mono- or polysubstituted C1-6alkyl, optionally mono- or polysubstituted C2-6alkenyl, nitro, hydroxy, Ar2, N(R4aR4b), N(R4aR4b)sulfonyl, N(R4aR4b)carbonyl, C1-6alkyloxy, Ar2oxy, Ar2C1-6alkyloxy, carboxyl, C1-6alkyloxycarbonyl, or —C(═Z)Ar2; and the other one of R2a and R3a is hydrogen; in case R2a is different from hydrogen then R2b is hydrogen, C1-6alkyl or halogen and R3b is hydrogen; in case R3a is different from hydrogen then R3b is hydrogen, C1-6alkyl or halogen and R2b is hydrogen. Compositions containg these compounds as active ingredient and processes for preparing these compounds and compositions.